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Vol. 13. Núm. 5.
Páginas 209-218 (enero 2001)
Vol. 13. Núm. 5.
Páginas 209-218 (enero 2001)
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Los fitosteroles, el colesterol y la prevención de las enfermedades cardiovasculares
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I. Plaza1
Unidad de Cardiología Preventiva y Rehabilitación. Hospital La Paz. Madrid
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Bibliografía
[1.]
P.H.J. Jones, T. Howell, D.E. MacDougall, J.Y. Feng, W. Parsons.
Shortterm administration of tall oil phytosterols improves plasma lipid profiles in subjects with different cholesterol levels.
Metabolism, 47 (1998), pp. 751-756
[2.]
P.H.J. Jones, F.Y. Ntanios, M.R. Racini-Sarjaz, C.A. Vanstone.
Cholesterol lowering efficacy of a sitostanol-containing phytosterol mixture with a prudent diet in hyperlipidemic men.
Am J Clin Nutr, 69 (1999), pp. 1144-1150
[3.]
J.A. Westtrate, G.W. Meijer.
Plant sterol-enriched margarines and reduction of plasma total and LDL-cholesterol concentration in normocholesterolaemic and mildly hypercholesterolaemic subjets.
Eur J Clin Nutr, 52 (1998), pp. 334-343
[4.]
H.F.J. Hendriks, J.A. Westrate, T. van Vliet, G.W. Meijer.
Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercolesterolaemic subjets.
Eur J Clin Nutr, 53 (1999), pp. 319-327
[5.]
T.A. Miettinen, P. Puska, H. Gylling, H. Vanhanen, E. Vartianen.
Reduction of serum cholesterol with sitostanol-ester margarine in a mildly hypercholesterolaemic population.
N Engl J Med, 333 (1995), pp. 1308-1312
[6.]
M.A. Hallikainen, M.I. Uusitupa.
Effects of 2 low-fat stanol estercontaining margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects.
Am J Clin Nutr, 69 (1999), pp. 403-410
[7.]
T.T. Nguyen.
The cholesterol-lowering action of plant stanol esters.
J Nutr, 129 (1999), pp. 2109-2112
[8.]
A. Anderson, B. Karlstrom, R. Mohsen, B. Vessby.
Cholesterol-lowering effects of a stanol ester-containing low fat margarine used in conjunction with a strict lipid-lowering diet.
Eur Heart J, 20 (Supl S (1999), pp. 80-90
[9.]
E. Ros.
Digestión y absorción de las grasas. Posibilidades de modulación dietética y farmacológica.
Med Clin (Barc, 113 (1999), pp. 337-348
[10.]
E. Ros.
El colesterol de la dieta y su escasa influencia sobre la colesterolemia y el riesgo cardiovascular.
Clin Invest Arterioscler, 12 (Supl 2 (2000), pp. 20-26
[11.]
E. Ros.
Intestinal absorption of triglyceride and cholesterol. Dietary and pharmacological inhibition to reduce cardiovascular risk.
Atherosclerosis, 151 (2000), pp. 357-379
[13.]
H. Gylling, T.A. Miettinen.
The effect of cholesterol absorption inhibition on low density lipoprotein cholesterol level.
Atherosclerosis, 117 (1995), pp. 305-308
[14.]
T.A. Miettinen, M. Vuoristo, M. Nissinen, H.J. Järvinen, H. Gylling.
Serum, biliary, and fecal cholesterol and plant sterols in colectomized patients before and during consumption of stanol ester margarine.
Am J Clin Nutr, 71 (2000), pp. 1095-1102
[15.]
M.M. Best, C.H. Duncan, E.J. Van Loon, J.D. Wathen.
Lowering of serum cholesterol by the administration of a plant sterol.
Circulation, 10 (1954), pp. 201-206
[16.]
A.M. tLees, H.Y.I. Mok, R.S. Lees, M.A. McCluskey, S.M. Grundy.
Plant sterols as cholesterol-lowering agents: clinical trials in patients with hypercholesterolemia and studies of sterol balance.
Atherosclerosis, 28 (1977), pp. 325-338
[17.]
M.A. Hallikainen, E.S. Sarkkinen, M.I.J. Uusitupa.
Plant stanol esters affect serum cholesterol concentrations of hypercholesterolemic men and women in a dose-dependent manner.
J Nutr, 130 (2000), pp. 767-776
[18.]
I. Wester.
Dose responsiveness to plant stanol esters.
Eur Heart J, 20 (1999), pp. 104-108
[19.]
I. Plaza, F. Villar, P. Mata, F. Pérez Jiménez, A. Máiquez, J.A. Casasnovas, et al.
Control de la colesterolemia en España. Un instrumento para la prevención cardiovascular.
Rev Esp Cardiol, 53 (2000), pp. 815-837
[20.]
F. Pérez Jiménez, C. Garcés, J. López Miranda, M. de Oya.
La dieta mediterránea como modelo nutricional para la prevención de las enfermedades cardiovasculares.
Cardiología preventiva, pp. 179-195
[21.]
P. Kris-Etherton, R.H. Eckel, B.V. Howard, S. Jeor, T.L. Bazzarre.
Lyon Diet Heart Study. Benefits of a Mediterranean–style, National Cholesterol Education Program/American Heart Association step I dietary pattern on cardiovascular disease.
Circulation, 102 (2001), pp. 1821-1822
[23.]
N.B. Cater.
Historical and scientific basis for the development of plant stanol ester foods as cholesterol-lowering agents.
Eur Heart J, 20 (1999), pp. 36-44
[24.]
T. Heinemann, A. Kullak-Ublick, B. Pietruck, K. von Bergmann.
Mechanisms of action of plant sterols on inhibition of cholesterol absorption.
Eur J Clin Pharmacol, 40 (1991), pp. 59-63
[25.]
C.J. Glueck, J. Speirs, T. Tracy, P. Streicher, E. Illig, J. Vandegrift.
Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hyperphytosterolemic probands and their first-degree relatives.
Metabolism, 40 (1991), pp. 842-848
[26.]
C.L. Williams, M. Bollella, B.A. Strobino, L. Boccia, L. Campanaro.
Lipid-lowering effects of a plant stanol ester spread in young children.
Eur Heart J, 20 (1999), pp. 96-103
[27.]
M. Becker, D. Staab, K. Von Bergmann.
Long-term treatment of severe familial hypercholesterolemia in children: effect of sitosterol and bezafibrate.
Pediatrics, 89 (1992), pp. 138-142
[28.]
M. Becker, D. Stabb, K. von Bergmann.
Treatment of severe familial hypercholesterolemia in childhood with sitosterol and sitostanol.
J Pediatr, 122 (1993), pp. 292-296
[29.]
H. Gylling, M.A. Siimes, T.A. Miettinen.
Sitosterol ester margarine in dietary treatment of children with familial hypercholesterolemia.
J Lipid Res, 36 (1995), pp. 1807-1812
[30.]
H. Gylling, T.A. Miettinen.
Cholesterol reduction by different plant stanol mixtures and with variable fat intake.
Metabolism, 48 (1999), pp. 575-580
[31.]
J.A. Westrate, R. Ayesh, C. Bauer-Planck, P.N. Drewitt.
Safety evaluation of phytosterol-esters. Part 4. Faecal concentrations of bile acids and neutral sterols in healthy normolipidemic volunteers consuming a controlled diet either with or without a phytosterolester margarine.
Food Chem Toxicol, 37 (1999), pp. 1063-1071
[32.]
S.N. Blair, D.M. Capuzzi, S.O. Gottlieb, T. Nguyen, J.M. Morgan, N.B. Cater.
Incremental reduction of serum total cholesterol and low-density lipoprotein cholesterol with the addition of plant stanol estercontaining spread to statin therapy.
Am J Cardiol, 86 (2000), pp. 46-52
[33.]
H. Gylling, T.A. Miettinen.
Serum cholesterol and cholesterol and lipoprotein metabolism in hypercholesterolaemic NIDDM patients before and during sitostanol ester-margarine treatment.
Diabetologia, 37 (1994), pp. 773-780
[34.]
H. Gylling, R. Radhakrishnan, T.A. Miettinen.
Reduction of serum cholesterol in postmenopausal women with previous myocardial infarction and cholesterol malabsorption induced by dietary sitostanol ester margarine.
Circulation, 96 (1997), pp. 4226-4231
[35.]
A.F. Vuorio, H. Gylling, H. Turtola, K. Kontula, P. Ketonen, T.A. Miettinen.
Stanol ester margarine alone and with simvastatin lowers serum cholesterol in families with familial hypercholesterolemia caused by the FH-North Karelia mutation.
Arterioscler Thromb Vasc Biol, 20 (2000), pp. 500-506
[36.]
T.A. Miettinen, T.E. Strandberg, H. Gylling.
Noncholesterol sterols and cholesterol lowering by long-term simvastatin treatment in coronary patients: relation to basal serum cholestanol.
Arterioscler Thromb Vasc Biol, 20 (2000), pp. 1340-1346
[37.]
L. Normen, P. Dutta, A. Lia, H. Anderson.
Soy sterol esters and betasitostanol ester as inhibitors of cholesterol absorption in human small bowel.
Am J Clin Nutr, 71 (2000), pp. 908-913
[38.]
J. Plat, R.P. Mensink.
Vegetable oil versus wood based stanol ester mixtures: effects on serum lipids and hemostatic factors in nonhypercholesterolemic subjects.
Atherosclerosis, 148 (2000), pp. 101-112
[39.]
M.A. Hallikainen, E.S. Sarkkinen, M.I.J. Uusitupa.
Effects of low-fat stanol ester enriched margarine on concentrations of serum carotenoids in subjects with elevated serum cholesterol concentrations.
Eur J Clin Nutr, 53 (1999), pp. 966-969
[40.]
P.A. Hepburn, S.A. Horner, M. Smith.
Safety evaluation of phytosterol esters. Subchronic 90-day oral toxicity study on phytosterol esters, a novel functional food.
Food Chem Toxicol, 37 (1999), pp. 521-532
[41.]
S.B. Patel, G. Salen, H. Hidaka, P.O. Kwiterovich, A.F. Stalenhoef, T.A. Miettinen, et al.
Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found at chromosome 2p21.
J Clin Invest, 102 (1998), pp. 1041-1044
[42.]
Commission Decision on authorising the placing on the market of yellow fat spreads with added phytosterol esters as a novel food or novel food ingredient under regulation (EC) No 258/97 of the European Parliament and of the Council.
Official Journal of the European Communities. C, 2121 (2000), pp. 59-60
[43.]
H. Tunstall-Pedoe, K. Kuulasmaa, M. Mahonen, H. Tolonen, E. Ruokokoski, P. Amouyel, et al.
Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA Project populations.
Lancet, 353 (1999), pp. 1547-1557
[44.]
P. Mata, M. de Oya, F. Pérez-Jiménez, E. Ros.
Dieta y enfermedades cardiovasculares. Recomendaciones de la Sociedad Española de Arteriosclerosis.
Clin Invest Arterioscler, 6 (1994), pp. 43-61
[45.]
D. Wood, G. de Backer, O. Faergerman, I. Graham, G. Mancia, K. Pyörälä.
Prevention of coronary heart disease in clinical practice. Recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention.
Eur Heart J, 19 (1998), pp. 1434-1503
[46.]
National Cholesterol Education Program. Second Report of the Expert Panel on Detection, Evaluation and Treatment of high blood cholesterol in adults (Adult Treatment Panell II).
Circulation, 89 (1994), pp. 1329-1445
[47.]
The Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).
Lancet, 344 (1994), pp. 1383-1389
[48.]
F.M. Sacks, M.A. Pfeffer, L.A. Moye, J.L. Rouleau, J.D. Rutherford, T.G. Cole, et al.
The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators.
N Engl J Med, 335 (1996), pp. 1001-1009
[49.]
The Long Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels.
N Engl J Med, 339 (1998), pp. 1349-1357
[50.]
M. De Lorgeril, P. Salen, J.L. Martin, I. Monjaud, J. Delaye, N. Mamelle.
Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study.
Circulation, 99 (1999), pp. 779-785
[51.]
GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial.
Lancet, 354 (1999), pp. 447-455
[52.]
M.L. Burr, M. Fehily, J.F. Gilbert, S. Rogers, M.R. Holliday, P.M. Sweetnam, et al.
Effects of changes in fat, fish, and fibre intakes on death and myocardial infarction: diet and reinfarction trial (DART.
Lancet, 2 (1989), pp. 757-761
[54.]
R.B. Singh, S.S. Rastogi, R. Verma, L. Bolaki, R. Singh.
Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up.
BMJ, 304 (1992), pp. 1015-1019
[55.]
S. Dayton, M.L. Pearce, S. Hashimoto, W.S. Dixon, U. Tomiyasu.
A controlled clinical trial of a diet high in monounsaturated fat in preventing complication of atherosclerosis.
Circulation, (1969), pp. 39-40
[56.]
A.C. Arntzenius, D. Kromhout, J.D. Barth, J.H.C. Reiber, A.V.G. Bruschke, B. Buis, et al.
Diet, lipoproteins, and the progression of coronary atherosclerosis. The Leiden Intervention Trial.
N Engl J Med, 312 (1985), pp. 805-811
[57.]
D. Ornish, S.E. Brown, L. Scherwitz, J. Billings, W. Armstrong, T. Ports, et al.
Can lifestyle changes reverse coronary heart disease?.
Lancet, 336 (1990), pp. 129-133
[58.]
I. Plaza, J.A. Gómez Guindal.
Cambio de actitud de los cardiólogos españoles respecto al tratamiento hipolipemiante en prevención secundaria de la cardiopatía isquémica.
Clin Invest Arterioscler, 11 (1999), pp. 8-15
[59.]
The Post CABG Trials Investigators. The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronaryartery bypass grafts. The Post Coronary Artery Bypass Graft Trial Investigators.
N Engl J Med, 336 (1997), pp. 153-162
[60.]
B. Pitt, D. Waters, W.V. Brown, J. Van Boven, L. Schwartz, L.M. Title, et al.
Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease.
N Engl J Med, 341 (1999), pp. 70-76
[61.]
S.M. Grudy.
Stanol esters as a dietary adjunct to cholesterol-lowering therapies.
Eur Heart J, 1 (1999), pp. 132-138
[62.]
H.A.W. Neil, G.W. Meijer, L.S. Roe.
Randomised controlled trial of use by hypercholestrolaemic patients of a vegetable oil sterol-enriched fat spread.
Atherosclerosis, 156 (2001), pp. 329-337
[63.]
I. Plaza.
y Grupo de Expertos de las Sociedades Españolas de Arteriosclerosis, Cardiología, Pediatría, Nutrición y Medicina Preventiva. Informe sobre el colesterol en niños y adolescentes Españoles.
Rev Esp Cardiol, 44 (1991), pp. 567-585
[64.]
S.C. Couch, A.T. Cross, K. Kida, E. Ros, I. Plaza, S. Shea, R.D. Deckelbaum.
Rapid westernization of children’s blood cholesterol in 3 countries: evidence for nutrient-gene interactions?.
Am J Clin Nutr, 72 (2000), pp. 1266-1274
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