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Vol. 68. Núm. 1.
Páginas 119 (enero 2013)
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Vol. 68. Núm. 1.
Páginas 119 (enero 2013)
READER’S OPINION
Open Access
Differences in the mechanisms that induce obesity and metabolic syndrome in experimental animal models and humans may cause treatment failure
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Mustafa CakarI, Sevket BaltaII,
Autor para correspondencia
drsevketb@gmail.com

Tel.: +90 312-3044281
, Sait DemırkolII, Ugur KucukII, Seref DemırbasI
I Gulhane Medical Academy, Department of Internal Medicine, Ankara/Turkey.
II Gulhane Medical Academy, Department of Cardiology, Ankara/Turkey.
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Dear Editor,

We recently read the article ”Monosodium glutamate neonatal treatment induces cardiovascular autonomic function changes in rodents” by Signora Peres Konrad et al. with great interest(1). These authors concluded that obesity induced by neonatal monosodium glutamate treatment impairs cardiac autonomic function and most likely contributes to increased arterial pressure and insulin resistance in rats. The authors are to be commended for contributing such a well-designed and successfully presented study. We believe that these findings will guide further study of obesity and metabolic syndrome (MS).

Obesity is a growing public health problem, and metabolic syndrome is an important risk factor for cardiovascular diseases (2,3). Although it is correct that this study should be emphasized in terms of these factors, we believe that obesity and MS induced in rats with monosodium glutamate may differ from any hereditary or acquired obesity and from MS in humans, i.e., that the enzymatic pathways utilized by and the physiologic effects resulting from these two entities may be different. These differences may affect treatment success, and we believe that the study results should be assessed with this perspective in mind.

REFERENCES
[1]
SP Konrad , V Farah , B Rodrigues , RB Wichi , UF Machado , HF Lopes , et al.
Monosodium Glutamate Neonatal Treatment İnduces Cardiovascular Autonomic Function Changes İn Rodents.
Clinics, 67 (2012), pp. 14
[2]
L Bahia , LG Aguiar , N Villela , D Bottino , AF Godoy-Matos , B Geloneze , et al.
Relationship Between Adipokines, İnflammation, And Vascular Reactivity İn Lean Controls And Obese Subjects With Metabolic Syndrome.
Clinics, 61 (2006), pp. 40
[3]
TY Tsai , JF Cheng , YM Lai .
Prevalence of metabolic syndrome and related factors in Taiwanese high-tech industry workers.
Clinics, 66 (2011), pp. 5

No potential conflict of interest was reported.

Copyright © 2013. CLINICS
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