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Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severityJamila Al-Zadjali, Amal Al-Lawati, Nafila Al Riyami, Koukab Al Farsi, Najwa Al Jarradi, Ammar Boudaka, Ali Al Barhoumi, Mohsen Al Lawati, ... Jumana Saleh
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Highlights
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Low HDL-C and high ferritin are linked to increased Long-COVID-19 severity.
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Changes in HDL-C levels, significantly impact Long-COVID-19 progression.
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Ferritin may exacerbate disease progression by increasing oxidative stress.
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HDL-C and ferritin levels may serve as markers and therapeutic targets for Long-COVID-19.
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Health-Related quality of life by 31-item Cervantes scale in breast cancer survivors undergoing adjuvant endocrine therapyIsis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Andressa Miranda Machado, Paula Philbert Lajolo, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
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HIGHLIGHTS
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CS-31 seems to be appropriate for use in oncology and may help to monitoring adverse effects and HRQL.
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Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysisMaria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
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Highlights
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Obstructive sleep apnea affects one billion people worldwide and is associated with cardiometabolic risk and cognitive impairment.
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Drug therapy for the management of sleep apnea has been investigated, but no robust evidence that supports its benefits has been found to date.
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The combination of noradrenergic and antimuscarinic drugs shows promising results.
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Tanshinone IIA alleviates IL-1β-induced chondrocyte apoptosis and inflammation by regulating FBXO11 expressionJin Xu, XiaoCheng Zhi, YunHui Zhang, Ren Ding
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Highlights
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TAN IIA inhibits IL-1β from inducing apoptosis and inflammation in CHON-001 cells.
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FBXO11 overexpression inhibits the protective effect of TAN IIA on apoptosis and inflammation of CHON-001 cells.
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Suppressing PI3K/AKT and NF-κB pathways protects against apoptosis and inflammation of CHON-001 cells.
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TAN IIA treatment improves apoptosis and inflammation of chondrocytes in OA rats.
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Physicians’ attention to patients’ communication cues can improve patient satisfaction with care and perception of physicians’ empathyCarlos Frederico Confort Campos, Clarice Rosa Olivo, Milton de Arruda Martins, Patricia Zen Tempski
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Highlights
• Patient-doctor communication relates to patient satisfaction and perceived empathy.
• Patients asking questions was linked to poor satisfaction and empathy perceptions.
• Doctor's use of negative communication skills related to worse rapport with patients.
• Satisfaction and empathy are positively linked to patient affective expression.
• Doctors providing advice/suggestions positively correlated to patient satisfaction.
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Serum procalcitonin as a marker of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)Tao Jiang, Wen-Xian Ouyang, Yan-Fang Tan, Ying Yu, Xiao-Mei Qin, Hai-Yan Luo, Lian Tang, Hui Zhang, Shuang-Jie Li
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Highlights
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PCT was a highly sensitive marker to differentiate NICCD from cholestatic hepatitis patients.
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PCT was reduced when NICCD was treated.
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PCT is a much more effective marker to differentiate NICCD than the inflammatory markers.
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Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivationXiaoYong Wu, RuoMei Xin, YanZhong Zhang, ChengRui Yang, FangYuan Sun, YanLiang Wang, FengXian Zheng
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Highlights
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XBJ improves LPS-induced lung cell inflammation and pyroptosis.
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miR-181d-5p inhibits LPS-induced inflammatory response and pyroptosis of lung epithelial cells.
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XBJ elevates miR-181d-5p and improves LPS-induced pyroptosis of lung epithelial cells.
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XBJ upregulates miR-181d-5p and inhibits SPP1 to protect lung epithelial cells from LPS-induced injuries.
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Delayed diagnosis and increased mortality risk: Assessing the effects of the COVID-19 pandemic on breast cancer recurrenceLindson Mühlmann, Franklin Fernandes Pimentel, Daniel Guimarães Tiezzi, Hélio Humberto Angotti Carrara, Jurandyr Moreira de Andrade, Francisco José Candido dos Reis
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Highlights
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COVID-19 profoundly affected global healthcare including breast cancer management.
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The pandemic delayed recurrence diagnosis and increased post-recurrence mortality.
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Strategies for cancer patients' follow-up during health crises need improvements.
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microRNA-181a-5p promotes fibroblast differentiation of mesenchymal stem cells in rats with pelvic floor dysfunctionYongHong Zhang, HaiYang Yu, JianChao Li
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Highlights
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miR-181a-5p promotes fibroblast differentiation of BMSCs.
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miR-181a-5p promotes fibroblast differentiation of BMSCs by targeting MFN1.
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BMSCs containing miR-181a-5p improve PFD in SD rats by targeting MFN1 expression, thereby accelerating the fibroblast differentiation of BMSCs.
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Foxp3+CD39+CD73+ regulatory T-cells are decreased in the peripheral blood of women with deep infiltrating endometriosisLuiza Gama Coelho Riccio, Marina Paula Andres, Isabella Zurita Dehó, Giovanna Ometto Fontanari, Maurício Simões Abrão
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Highlights
• Tregs maintain self-tolerance and may allow the survival of ectopic endometrium.
• CD3+CD4+CD25High cells were similar between endometriosis and controls.
• CD3+CD4+CD25HighCD39+Foxp3+ cells were similar between endometriosis and controls.
• Foxp3+CD39+CD73+ Tregs are decreased in the blood of women with endometriosis.
• There is a decrease in systemic immune tolerance in patients with endometriosis.
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