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6
Screening and diagnostic tools for autism spectrum disorder: Systematic review and meta-analysis
Clara Lucato dos Santos, Indyanara Inacio Barreto, Idevaldo Floriano, Luca Schiliró Tristão, Antonio Silvinato, Wanderley Marques Bernardo
Clinics. 2024;79C:100323
6
Highlights

  • Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder.

  • Autism spectrum disorder has a significant impact on the patient and their family.

  • To provide adequate advice is to carry out screening and diagnosis correctly and accurately.

  • Screening test must be applied, M-CHAT-R/F is recommended.

  • For diagnosis CARS and ADOS are the most recommended tools.

Acceso a texto completo
5
Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis
Maria Luísa Nobre, Ayane Cristine Alves Sarmento, Priscila Farias de Oliveira, Felipe Ferreira Wanderley, José Diniz Júnior, Ana Katherine Gonçalves
Clinics. 2024;79C:100330
5
Highlights

  • Obstructive sleep apnea affects one billion people worldwide and is associated with cardiometabolic risk and cognitive impairment.

  • Drug therapy for the management of sleep apnea has been investigated, but no robust evidence that supports its benefits has been found to date.

  • The combination of noradrenergic and antimuscarinic drugs shows promising results.

Acceso a texto completo
4
Tanshinone IIA alleviates IL-1β-induced chondrocyte apoptosis and inflammation by regulating FBXO11 expression
Jin Xu, XiaoCheng Zhi, YunHui Zhang, Ren Ding
Clinics. 2024;79C:100365
4
Highlights

  • TAN IIA inhibits IL-1β from inducing apoptosis and inflammation in CHON-001 cells.

  • FBXO11 overexpression inhibits the protective effect of TAN IIA on apoptosis and inflammation of CHON-001 cells.

  • Suppressing PI3K/AKT and NF-κB pathways protects against apoptosis and inflammation of CHON-001 cells.

  • TAN IIA treatment improves apoptosis and inflammation of chondrocytes in OA rats.

Acceso a texto completo
4
Reduced HDL-cholesterol in long COVID-19: A key metabolic risk factor tied to disease severity
Jamila Al-Zadjali, Amal Al-Lawati, Nafila Al Riyami, Koukab Al Farsi, Najwa Al Jarradi, Ammar Boudaka, Ali Al Barhoumi, Mohsen Al Lawati, ... Jumana Saleh
Clinics. 2024;79C:100344
4
Highlights

  • Low HDL-C and high ferritin are linked to increased Long-COVID-19 severity.

  • Changes in HDL-C levels, significantly impact Long-COVID-19 progression.

  • Ferritin may exacerbate disease progression by increasing oxidative stress.

  • HDL-C and ferritin levels may serve as markers and therapeutic targets for Long-COVID-19.

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4
Physicians’ attention to patients’ communication cues can improve patient satisfaction with care and perception of physicians’ empathy
Carlos Frederico Confort Campos, Clarice Rosa Olivo, Milton de Arruda Martins, Patricia Zen Tempski
Clinics. 2024;79C:100377
4
Highlights

  • • Patient-doctor communication relates to patient satisfaction and perceived empathy.

  • • Patients asking questions was linked to poor satisfaction and empathy perceptions.

  • • Doctor's use of negative communication skills related to worse rapport with patients.

  • • Satisfaction and empathy are positively linked to patient affective expression.

  • • Doctors providing advice/suggestions positively correlated to patient satisfaction.

Acceso a texto completo
4
Esketamine alleviates hypoxia/reoxygenation injury of cardiomyocytes by regulating TRPV1 expression and inhibiting intracellular Ca2+ concentration
Ying Zhang, QuanMei Lu, HanChun Hu, ChunChen Yang, QiHong Zhao
Clinics. 2024;79C:100363
4
Highlights

  • ESK treatment can increase H9c2 cell viability and reduce apoptosis and intracellular Ca2+ concentration.

  • CAP treatment decreases H9c2 cell viability and increases apoptosis and intracellular Ca2+ concentration.

  • TRPV1 upregulation decreases H9c2 cell viability and increases cell apoptosis and intracellular Ca2+ concentration.

  • After overexpressing TRPV1, the protective effect of ESK on H/R injury of H9c2 cells is weakened.

Acceso a texto completo
3
Firmicutes/Bacteroidetes and Firmicutes/Proteobacteria ratios are associated with worse prognosis in a cohort of Latin American patients with cirrhosis
Augusto Mantovani, Larisse Longo, Rutiane Ullmann Thoen, Pabulo Henrique Rampelotto, Raul Salinas, Gabriel Tayguara Silveira Guerreiro, Mário Reis Álvares-da-Silva
Clinics. 2024;79C:100471
3
Highlights

  • Gut Microbiota (GM) has an important role in liver diseases progression.

  • Notable differences in GM and diversity exist between healthy individuals and cirrhosis patients.

  • Changes in GM are associated with an increased risk of mortality within 90 days.

  • Firmicutes/Bacteroidetes and Firmicutes/Proteobacteria predict hepatic decompensation and mortality.

Acceso a texto completo
3
Serum procalcitonin as a marker of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD)
Tao Jiang, Wen-Xian Ouyang, Yan-Fang Tan, Ying Yu, Xiao-Mei Qin, Hai-Yan Luo, Lian Tang, Hui Zhang, Shuang-Jie Li
Clinics. 2024;79C:100383
3
Highlights

  • PCT was a highly sensitive marker to differentiate NICCD from cholestatic hepatitis patients.

  • PCT was reduced when NICCD was treated.

  • PCT is a much more effective marker to differentiate NICCD than the inflammatory markers.

Acceso a texto completo
2
Health-Related quality of life by 31-item Cervantes scale in breast cancer survivors undergoing adjuvant endocrine therapy
Isis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Andressa Miranda Machado, Paula Philbert Lajolo, Carlos Eduardo Paiva, Yara Cristina de Paiva Maia
Clinics. 2024;79C:100324
2
HIGHLIGHTS

  • CS-31 seems to be appropriate for use in oncology and may help to monitoring adverse effects and HRQL.

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2
Xuebijing improves inflammation and pyroptosis of acute lung injury by up-regulating miR-181d-5p-mediated SPP1 inactivation
XiaoYong Wu, RuoMei Xin, YanZhong Zhang, ChengRui Yang, FangYuan Sun, YanLiang Wang, FengXian Zheng
Clinics. 2024;79C:100336
2
Highlights

  • XBJ improves LPS-induced lung cell inflammation and pyroptosis.

  • miR-181d-5p inhibits LPS-induced inflammatory response and pyroptosis of lung epithelial cells.

  • XBJ elevates miR-181d-5p and improves LPS-induced pyroptosis of lung epithelial cells.

  • XBJ upregulates miR-181d-5p and inhibits SPP1 to protect lung epithelial cells from LPS-induced injuries.

Acceso a texto completo
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