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Número
Vol. 80. (En progreso)
(enero - diciembre 2025)
Este sumario está en progreso pero sus artículos están finalizados y son citables.
Original articles
Lactylated histone H3K18 as a potential biomarker for the diagnosis and prediction of the severity of pancreatic cancer
Jinping Hou, Mingsong Guo, Yongqiong Li, Yijin Liao
Highlights

  • High level of Pan Lysine Lactylation (Pan-Kla) is found in pancreatic cancer tissues.

  • H3K18la levels are increased in pancreatic cancer tissues.

  • H3K18la is related to the severity and prognosis of pancreatic cancer.

Acceso a texto completo
The role of hormone dosages in the assessment of cervical lesions by FNA: A descriptive analysis of 762 cases
Arthur Henrique Cunha-Volpato, Carlos Izaias Sartorão Neto, Luiz Fernando Ferraz da Silva, Paulo Campos Carneiro
Highlights

  • Hormone measurement in FNA washout fluid is an accessible method for improving accuracy.

  • Thyroglobulin (TG) dosage can enhance the accuracy of detecting well-differentiated thyroid carcinomas.

  • Calcitonin dosage complements cytology in detecting medullary thyroid carcinoma cervical metastasis.

  • Post-thyroidectoby bed dosages help to determine non-thyroid/parathyroid lesions.

Acceso a texto completo
Correlation between liver volume drainage and clinical success after endoscopic biliary drainage of hilar malignant obstruction
Jennifer Nakamura Ruas, Ernesto Quaresma Mendonça, Luciano Lenz, Gustavo Andrade de Paulo, Ricardo Uemura Sato, José Jukemura, Ulysses Ribeiro Junior, Fauze Maluf-Filho, Bruno Costa Martins
Highlights

  • The main cause of hilar obstruction was cholangiocarcinoma (32.9 %) followed by lymph node metastasis (23.2 %).

  • Technical success was achieved in 91.5 %, clinical success in 60 %.

  • A significant correlation between clinical success rate was found when at least 50 % of viable parenchyma was drained (p = 0.016; OR = 4.15, 95 % CI 1.4–12.5).

  • Considering liver sectors, higher clinical success rates were found when at least 2 sectors were drained (p < 0.001; OR = 8.50, 95 % CI 2.7–26.7).

  • Correlation between unilateral versus bilateral drainage and clinical success was not statistically significant.

Acceso a texto completo
Descriptive study of claims in primary care during the year 2022 in a health area of Spain
María F. Velázquez-López, María García-Pérez, Montserrat Souto-Pereira, Juan M. Vazquez-Lago
Highlights

  • Analyzing complaints is essential for identifying areas for improvement.

  • 79 % of the complaints were related to communication issues with the patient.

  • Improving communication with the patient will help reduce the number of complaints filed.

  • Using a web application simplifies the management of complaints in primary care.

Acceso a texto completo
Anatomical variations of the marginal mandibular nerve
Arthur Paredes Gatti, Matheus Trovão Ribeiro, Flávio Hojaij
Highlights

  • Most surgeons underestimate the positional and numerical variations of the Facial Nerve.

  • About 50% of the Marginal Nerves of the Mandible have more than one subdivision.

  • Just over half of the branches of the Mandibular Marginal Nerve are found below the lower border of the mandible.

  • The great anatomical variation of the Mandibular Marginal Nerve is responsible for the majority of postoperative motor sequelae.

Acceso a texto completo
Infiltration of micro-fragmented adipose tissue under local anesthesia for knee osteoarthritis treatment is a safe procedure: A case series
Bruno Butturi Varone, Daniel Peixoto Leal, Daniel Duarte Perini, Vitor Penteado Figueiredo Pagotto, Riccardo Gomes Gobbi, Marco Kawwamura Demange
Highlights

  • Harvesting abdominal fat for mFAt knee injection is a safe procedure.

  • Minor events, such as ecchymosis, mild abdominal discomfort, and mild discomfort at the infiltrated knee are common.

  • The procedure can be done under local anesthesia, without sedation after single-time preparation.

Acceso a texto completo
Clinical and swallowing characteristics of tracheostomized patients with post-intubation acquired tracheal or laryngotracheal stenosis
Carina Escudero, Fernanda Chiarion Sassi, Ana Paula Ritto, Paulo Francisco Guerreiro Cardoso, Claudia Regina Furquim de Andrade
Highlights

  • Despite the efficacy of reconstructive surgeries and Montgomery T-tube, clinical and neurological instability significantly impact outcomes and prolong tracheostomy use.

  • Treatment for post-intubation tracheal or laryngotracheal stenosis requires a multidisciplinary and personalized approach.

  • Dysphagia is a significant factor linked to poorer clinical outcomes and extended tracheostomy use.

Acceso a texto completo
The impact of photodynamic therapy on cellular immune function in patients with cervical HPV infection
Yan Ju, Qunyan Zhou
Highlights

  • Photodynamic Therapy (PDT) significantly increased HPV clearance rates in cervical HPV-infected patients.

  • PDT treatment augmented CD3+ and CD4+ T-cell levels, with sustained elevation observed up to 6 months post-treatment.

  • A higher CD4+/CD8+ ratio was noted in the PDT group, indicating an enhanced cellular immune response.

  • Pro-inflammatory cytokines IL-6, IL-8, and TNF-α levels decreased post-PDT, suggesting reduced inflammation.

Acceso a texto completo
Clinical study of the effect of mometasone furoate nasal spray treatment on hearing and in secretory otitis media in children
Xiaoyan Yu, Lang Xu, Youqi Xie, Mengjie Huang
Highlights

  • The total effective rate of treatment in the observation group was higher than that in the control group.

  • The middle ear resonance frequency of the children in the observation group was higher than that of the control group at weeks 4, 8 and 12 of treatment, and the air-conduction hearing threshold was lower than that of the control group.

  • The total effective rate of the observation group after 12 weeks of treatment was 92.11 %, which was significantly higher than that of the control group (73.68 %).

  • The T-ETDQ score of the observation group was lower than that of the control group after treatment.

Acceso a texto completo
Diagnostic value of contrast-enhanced ultrasound combined with serum procalcitonin in tuberculous lymph nodes and metastatic lymph nodes
Lin Li, Lan He, Minchao Xiong, Xiaoyan Wang
Highlights

  • According to imaging findings of CEUS, TLN was associated with enhanced concentric performance in the arterial phase and heterogeneous enhancement pattern in lymph nodes.

  • Peak Intensity (PI) of lesions was higher in MLN patients.

  • Increased age-enhanced concentric performance in the arterial phase, increased PI, and serum PCT above 5.39 ng/mL were independent risk factors for MLN.

  • The prediction model of serum PCT combined with CEUS had a higher diagnostic value for MLN.

Acceso a texto completo
The effect of Licochalcone A on proliferation, invasion, and drug resistance of glioma cells by regulating TLR4/NF-κB signaling pathway
Baigui Zhou, Kun Mu, Xuzhou Yu, Xu Chen, Xiaoying Shi
Highlights

  • LCA has the ability to suppress the growth, movement, and invasion of glioma cells.

  • It can also counteract resistance to TMZ drugs.

  • This opens up new possibilities for identifying clinical drugs to treat glioma patients who are resistant to TMZ.

Acceso a texto completo
A study on the intervention of eight-section brocade exercises in combination with comprehensive measures on the physical function status of patients with chronic obstructive pulmonary disease
Jiezhen Li, Yan Lei, Meini Li
Highlights

  • Eight-section brocade exercises enhance exercise endurance and lung function of COPD patients.

  • Eight-section brocade exercises improve the physical function of COPD patients.

  • Eight-section brocade exercises improve patient emotions, nursing efficiency, and satisfaction.

Acceso a texto completo
CST1 promoted gastric cancer development by activating the AKT pathway
Lei Zhang, Dongmei Wang, Liqun Zhang, Lini Zhu
Highlights

  • Comparison of the invasive capabilities.

  • Comparison of the metastatic capabilities.

  • Effect of CST1 and AKT mRNA in gastric cancer.

  • Effect of CST1 and AKT protein in gastric cancer.

Acceso a texto completo
Gyosaponin ameliorates sevoflurane anesthesia-induced cognitive dysfunction and neuronal apoptosis in rats through modulation of the PI3K/AKT/mTOR pathway
Lijuan Lin, Chenhui Zhu, Bing Yan, Pinxian Yu, Liu Yang, Wei Huang, Junren Chen
Highlights

  • GpS ameliorates Sev-induced cognitive deficits in rats.

  • GpS ameliorates Sev-induced neuronal cell damage in rats.

  • GpS promotes activation of the PI3K/AKT/mTOR pathway.

  • PI3K/AKT/mTOR pathway inhibitor reduces the amelioration of cognitive deficits in Sev-anesthetized rats by high-dose GpS.

  • PI3K/AKT/mTOR pathway inhibitor impairs the ameliorative effect of high-dose GpS on neuronal cell damage in Sev-anesthetized rats.

Acceso a texto completo
Effect of melatonin on postoperative cognitive function in elderly patients submitted to transurethral resection of the prostate under spinal anesthesia
Cristiane Tavares, Cláudia Maia Memória, Luiz Guilherme Villares da Costa, Vinícius Caldeira Quintão, Alberto Azoubel Antunes, Deborah Teodoro, Maria José Carvalho Carmona
HIGHLIGHTS

  • Perioperative Neurocognitive Disorders (PND) can occur in patients submitted to elective surgical procedures under general or regional anesthesia, especially the elderly.

  • Circadian rhythm disruptions have harmful effects on cognition and may also play a role in the development of PND.

  • Melatonin 10 mg administered in the perioperative period of TURP surgery for elderly patients hasn't shown any protective effect against postoperative cognitive decline, mainly because the patients have shown a significant improvement in cognitive functions after the surgery.

Acceso a texto completo
Agreement analysis and associated factors of SARC-F and SARC-CALF in screening of risk sarcopenia in people living with human immunodeficiency virus
Lara Cristina Vieira, Jaine Alves Ximenez, Maria Claudia Bernardes Spexoto
Highlights

  • SARCCalf is better than SARC-F in screening the risk of sarcopenia in PLHIV.

  • Low CD4+ count, the presence of opportunistic infections, and AIDS status are associated with the risk of sarcopenia in PLHIV, regardless of the tool used.

Acceso a texto completo
Incidence of mycobacteria in pulmonary granulomatous lesions
Sibele Inácio Meireles, Mariana Vargas Cruz, Gustavo Palmer Irffi, Leonardo Abreu Testagrossa
Highlights

  • Lung granulomas have been associated with mycobacteria and fungal infections.

  • The largest cohort of pulmonary granulomatous lesions in Brazil was studied.

  • FFPE specimens are a valuable source of material for molecular methods.

  • Molecular methods contribute to the fast diagnosis of all mycobacteria species.

Acceso a texto completo
Role of centchroman in regression of fibroadenoma: A 2-arm randomized control trial
Priyanka Rai, Soniya Nityanand, Amarjot Singh, Sunil Kumar Singh, Neha Singh, Arvind Kumar Singh, Dhananjay Singh
Highlights

  • The findings of the study indicate that Centchroman led to a notable reduction in fibroadenoma size, with a significant proportion of patients experiencing more than 50 % regression in their fibroadenomas.

  • Patients experienced significant relief from breast pain (mastalgia), showcasing the efficacy of Centchroman in alleviating associated physical discomfort.

  • Centchroman led to a significant improvement in anxiety and depression scores, highlighting its positive impact on the psychological health and overall well-being of patients.

Acceso a texto completo
The impact of clinical seizures and adverse brain MRI patterns in neonates with hypoxic-ischemic encephalopathy and abnormal neurodevelopment
Sae Yun Kim, Hyun-Mi Kang, Soo-Ah Im, Young-Ah Youn
Highlights

  • Electrographic seizures did not have predictive value for adverse neurodevelopmental outcomes at 12‒24 months of age.

  • The incidence of neurodevelopmental impairment or death was significantly higher in the clinical seizure group.

  • Only cord blood pH and abnormal brain MRI findings were consistently associated with long-term neurodevelopmental outcomes in a multivariate analysis.

Acceso a texto completo
Bleeding in patients hospitalized with acute pulmonary embolism in Brazil
Leonardo Jordan Hansen Vizzotto, Corina dos Reis Sepeda, Carlos Henrique Miranda
Highlights

  • Antithrombotics are the cornerstone for acute Pulmonary Embolism (APE) treatment.

  • Patients hospitalized with APE in Brazil had a high prevalence of bleeding.

  • The major bleeding increased the one-year mortality rate.

  • The bleeding predictive scores assessed showed limited accuracy in identifying high bleeding-risk patients.

Acceso a texto completo
Review articles
Towards optimal management of lower eyelid malpositions: A systematic review of treatment effectiveness and safety
Lana Sbitan, Haneen Tanous, Mira Nawfal Jardak, Cristina Pires Camargo
Highlights

  • A comprehensive systematic review was conducted, to provide healthcare workers with a vital resource in the treatment of eyelid malposition, our search spanned electronic databases, clinical trials registries, and relevant journals.

  • The study includes 15 selected trials evaluating 709 patients (855 eyelids), with an assessment of trial quality using the Cochrane Risk-of-Bias tool (RoB V2).

Acceso a texto completo
Personalized nutrition and precision medicine in perimenopausal women: A minireview of genetic polymorphisms COMT, FUT2, and MTHFR
Pedro Andrade, Aline Boveto Santamarina, Jéssica Alves de Freitas, Annete Bressan Rente Ferreira Marum, Ana Flávia Marçal Pessoa
Acceso a texto completo
Behavioral therapies for the treatment of autism spectrum disorder: A systematic review
Clara Lucato dos Santos, Indyanara Inacio Barreto, Ana Carolina Furian da Silva, Juliana Firmino Batista Soriano, Jeferson de Lima Silva Castro, Luca Schiliró Tristão, Wanderley Marques Bernardo
Highlights

  • Autism Spectrum Disorder (ASD) is a heterogeneous neurodevelopmental disorder.

  • With correct screening and diagnosis, treatment must be offered to improve prognosis.

  • Adequate treatment in a healthcare setting must be known.

  • The Early Start Denver Model (ESDM) showed improvements in the cognitive, verbal, and social aspects.

  • Time occasionally can improve some scores independently of the group.

Acceso a texto completo
Comments
Updated report of Blastocystis spp. in a teaching hospital of Brazil: A 6-year retrospective experience
Gessica Baptista de Melo, Marcelo Alves Ferreira, Vera Lucia Pagliusi Castilho, Elenice Messias do Nascimento Gonçalves, Ronaldo Cesar Borges Gryschek, Fabiana Martins de Paula
Acceso a texto completo
Correspondence
Role of tomography in the screening at the emergency room during pandemics
Marcel Lima Albuquerque, Ricardo D'Oliveira Vieira, Luiz Eduardo Fonteles Ritt
Acceso a texto completo
New, late-onset relapsing-remitting multiple sclerosis in a woman in her 60s after SARS-CoV-2 vaccination
Carla Alexandra Scorza, Fulvio Alexandre Scorza, Josef Finsterer
Acceso a texto completo
Erratums
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