An 87-year-old male in oncology follow-up after a surgically treated gastrointestinal stromal tumour (GIST). The follow-up CT scan revealed concentric wall thickening in the ascending colon (Fig. 1). Tests were completed with colonoscopy, where a circumferential ulcerated lesion was identified in the caecum (Fig. 2). Pathology examination revealed the presence of oval cells with central rounded nuclei and metachromatic cytoplasm compatible with mast cells infiltrating the lamina propria and demonstrating CD117 immunoreactivity (Fig. 3). Despite these findings, due to the patient's underlying disease, it was decided not to continue the study of systemic mastocytosis (SM).
Mastocytosis is a rare disease that can affect the skin exclusively (cutaneous mastocytosis) or multiple organs (systemic mastocytosis).
Around 70–80% of patients with SM are found to have gastrointestinal involvement.
Endoscopic findings vary from nodular involvement to pigmented areas, thickened folds or even a normal study. However, our case atypically presented with an ulcerated lesion.1
There are studies that question whether mast cell aggregates in the bowel mucosa in asymptomatic patients have any systemic significance.2,3 We should therefore interpret this histological finding with caution in order to avoid unnecessary medical procedures.
Please cite this article as: Pradera Cibreiro C, Ramos Alonso M, Vázquez Bueno JÁ, Molina Arriero G. Úlcera colónica como hallazgo infrecuente de mastocitosis. Gastroenterol Hepatol. 2021;44:380–381.