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Inicio Gastroenterología y Hepatología (English Edition) Year 2001: Link between susceptibility to Crohn's disease and variations in LRR
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Vol. 43. Núm. 7.
Páginas 381-382 (agosto - septiembre 2020)
Vol. 43. Núm. 7.
Páginas 381-382 (agosto - septiembre 2020)
Chronography of Inflammatory Bowel Disease
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Year 2001: Link between susceptibility to Crohn's disease and variations in LRR
Año 2001: asociación entre la susceptibilidad a la enfermedad de Crohn y las variaciones de LRR
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Ignacio Marín-Jiméneza, Fernando Gomollónb,c,d,
Autor para correspondencia
fgomollon@gmail.com

Corresponding author.
a Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Aparato Digestivo, Hospital Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain
b Unidad de Enfermedad Inflamatoria Intestinal, Servicio de Aparato Digestivo, Hospital Clínico Universitario Lozano Blesa, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Zaragoza, Spain
c Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Madrid, Spain
d Facultad de Medicina, Universidad de Zaragoza, Zaragoza, Spain
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It was already known that Crohn's disease has a crucial genetic aetiological component due to its very different concordance in monozygotic twins (37%) compared to that in dizygotic twins (7%). In 1996, Jean-Pierre Hugot et al. published the first genome-wide association study identifying a locus of susceptibility to Crohn's disease adjacent to the centromere of chromosome 16, called IBD1. In 2001 two articles were published in the same issue of the journal Nature (one of which we analyzed in detail in the next infographic) which described the gene and the various polymorphisms of IBD1 that confer susceptibility to the disease. Inherited susceptibility to Crohn's disease associated with NOD2 gene polymorphisms behave in part as an inherited genetic metering effect and in part as a recessive autosomal inheritance. Thus, heterozygotes have a slight increase in risk (relative risk of 3), while compound heterozygotes and homozygotes have a high relative risk (relative risk of 44 and 38, respectively). We also wished to single out from these two papers the work done by Hugot's group, since Professor Miquel Àngel Gassull was one of the first authors in said study, to our great appreciation. In recent years, a multitude of papers have continued to be published related to both Crohn's disease and ulcerative colitis and the various genes and polymorphisms thereof (more than 240 risk loci). However, the genetic component is still only able to explain a small percentage (less than 30%) of the overall effect of susceptibility to IBD, which suggests a need to deepen the study of environmental factors and intestinal microbiota as crucial elements for the onset and perpetuation of the disease.

Please cite this article as: Marín-Jiménez I, Gomollón F. Año 2001: asociación entre la susceptibilidad a la enfermedad de Crohn y las variaciones de LRR. Gastroenterol Hepatol. 2020;43:381–382.

Copyright © 2020. The Author(s)
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