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array:23 [ "pii" => "S0025775300712310" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71231-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71231" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:165-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1423 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1324 "PDF" => 92 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712322" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71232-2" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71232" "copyright" => "Elsevier España, S.L." 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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:161-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2103 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2013 "PDF" => 84 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Mortalidad hospitalaria en la hemorragia subaracnoidea. Experiencia del «Registro Barcelona de Enfermedades Cerebrovasculares»" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "161" "paginaFinal" => "164" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "In-hospital mortality due to subarachnoid hemorrhage in the «Barcelona Stroke Registry»" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Adrià Arboix" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Adrià" "apellidos" => "Arboix" ] ] ] 1 => array:2 [ "autoresLista" => "Josep Lluís Martí-Vilalta" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Josep" "apellidos" => "Lluís Martí-Vilalta" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712309?idApp=UINPBA00004N" "url" => "/00257753/0000011400000005/v1_201307291446/S0025775300712309/v1_201307291446/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Factores asociados al desarrollo de atopia en adultos jóvenes" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "165" "paginaFinal" => "168" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Xavier Cortès, Joan B. Soriano, Jordi Sunyer, Jesús Martínez-Moratalla, Nerea Muniozgoren, José Antonio Maldonado, Ramón Quirós, Josep M.<span class="elsevierStyleSup">a</span> Antó" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Xavier" "apellidos" => "Cortès" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "Joan B." "apellidos" => "Soriano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 2 => array:4 [ "nombre" => "Jordi" "apellidos" => "Sunyer" "email" => array:1 [ 0 => "jsunyer@imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 3 => array:3 [ "nombre" => "Jesús" "apellidos" => "Martínez-Moratalla" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 4 => array:3 [ "nombre" => "Nerea" "apellidos" => "Muniozgoren" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] 5 => array:3 [ "nombre" => "José" "apellidos" => "Antonio Maldonado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] ] ] 6 => array:3 [ "nombre" => "Ramón" "apellidos" => "Quirós" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff00025" ] ] ] 7 => array:3 [ "nombre" => "Josep M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Antó" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Unitat de Recerca Respiratòria i Ambiental. IMIM. Barcelona</span>" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Unidad de Neumología. Hospital General de Albacete</span>" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] 2 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Dirección General de Salud de Vizcaya. Bilbao</span>" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] 3 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Servicio de Neumología. Hospital General de Huelva</span>" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] 4 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Dirección de Salud Pública. Consejería de Sanidad de Asturias. Oviedo</span>" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff00025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Unitat de Recerca Respiratòria i Ambiental. Institut Municipal d#Xx0027;Investigació Mèdica. Doctor Aiguader, 80. 08003 Barcelona." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Factors associated to the development of atopy in young Spanish adults" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-09-17" "fechaAceptado" => "1999-12-14" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221285" "palabras" => array:4 [ 0 => "Atopia" 1 => "Educación" 2 => "Familia" 3 => "Infecciones respiratorias" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar los factores de riesgo para el desarrollo de atopia en adultos jóvenesespañoles.</p> <span class="elsevierStyleSectionTitle">PoblaciÓn y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de casos y controles sobre casos prevalentes basado en población generalde edades comprendidas entre 20 y 44 años. Fue estudiada una muestra aleatoria y representativade los adultos jóvenes españoles participantes en el European Community RespiratoryHealth Survey (ECRHS) (n = 16.884), a partir de la cual se seleccionó una submuestra tambiénaleatoria del 20% de los sujetos, que realizaron un cuestionario corto sobre síntomas respiratoriosy a los cuales les fue evaluada la atopia. Definimos atopia como la existencia de cifras detectablesde IgE específica en suero contra los siguientes aeroalergenos comunes: pelo de gato, Cladosporiumherbarum, Dermathophagoides pteronyssinus, Parietaria judaica y Phleum pratense.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Además del sexo masculino y las edades tempranas, alergia materna (OR = 1,63;IC del 95% = 1,11-2,40), tener algún hermano alérgico (OR = 1,40; IC del 95% = 1,06-1,90)y un nivel educacional elevado (OR = 1,69; IC del 95% = 1,22-2,34) se asociaron a la presenciade cifras elevadas de IgE específicas. Además, tener hermanos mayores, especialmente sison varones, parece tener un efecto protector contra el desarrollo de atopia, aunque no de formaestadísticamente significativa; igualmente, haber tenido un pájaro en casa aumentaba elriesgo, aunque esta asociación tampoco fue significativa.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Además de las variables familiares que indican tanto factores genéticos como ambientales,el nivel educativo parece tener algún grado de asociación con la atopia, indicando quelas variables relacionadas con el estilo de vida intervienen de forma importante en su desarrollo.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To determine the risk factors for the development of atopy in Spanish young adults.</p> <span class="elsevierStyleSectionTitle">Subjets and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Case-control study over prevalent cases. Carried out in general populationbetween the ages of 20 to 44 years old. Spanish participants of the ECRHS, a ramdom representativesample of Spanish young adults (n = 16,884), and a 20% randomised subsamplemade by those who answered to a short respiratory questionnaire and had atopy assessed, wasstudied. Atopy was defined as having serum specific IgE positivity to the following aeroallergnes:cat dander, Cladosporium herbarum, Dermatophagoides pteronyssinus, Parietaria judaicaand Phleum pratense.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Several factors had a statistically significant effect. In addition to male gender and lowerage, maternal allergy (OR = 1.63; 95% CI = 1.11-2.40), having allergic siblings (OR =1.40; 95% CI = 1.06-1.90) and a higher educational level (OR = 1.69; 95% CI = 1.22-2.34)were associated with the presence of high levels of specific IgE in our sample. Moreover, havinghad older siblings, especially older brothers appears to be a protective factor to the developmentof atopy but not in a statistically significant way, while having had pet birds duringchildhood appears to enhance the risk.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In addition to the familial variables that indicates both environmental and geneticfactors, educational level seems to have low degree of association with atopy; this featureshows that variables related with life style are involved in atopy development.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:38 [ 0 => array:3 [ "identificador" => "bib00005" "etiqueta" => "1." 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