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array:23 [ "pii" => "S0025775300711857" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71185-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71185" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:46-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6371 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 6235 "PDF" => 127 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300711869" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71186-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71186" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:50-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3448 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 3286 "PDF" => 151 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Manifestaciones clínicas de la hipercolesterolemia familiar heterozigota en España. Estudio de 301 casos de la zona centro y norte" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "50" "paginaFinal" => "51" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical manifestations of heterozygous familial hipercholesterolaemia in Spain. Report of 301 cases from the central and northern areas" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carmen Garcés, Fernando Rodríguez Artalejo, Adalberto Serrano, José González Bonillo, Fatima Almagro, Juan Antonio Garrido, Manuel Zúñiga, Manuel de Oya" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Carmen" "apellidos" => "Garcés" ] 1 => array:2 [ "nombre" => "Fernando Rodríguez" "apellidos" => "Artalejo" ] 2 => array:2 [ "nombre" => "Adalberto" "apellidos" => "Serrano" ] 3 => array:2 [ "nombre" => "José González" "apellidos" => "Bonillo" ] 4 => array:2 [ "nombre" => "Fatima" "apellidos" => "Almagro" ] 5 => array:2 [ "nombre" => "Juan Antonio" "apellidos" => "Garrido" ] 6 => array:2 [ "nombre" => "Manuel" "apellidos" => "Zúñiga" ] 7 => array:2 [ "nombre" => "Manuel" "apellidos" => "de Oya" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711869?idApp=UINPBA00004N" "url" => "/00257753/0000011400000002/v1_201307291440/S0025775300711869/v1_201307291440/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775300711845" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71184-5" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71184" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:41-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 182 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 106 "PDF" => 71 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Influencia de la presencia de sofocos durante la menopausia sobre el metabolismo del óxido nítrico. Efecto del tratamiento hormonal sustitutivo" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "41" "paginaFinal" => "45" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Influence of the presence of hot flushes durig the menopause in the metabolism of nitric oxide. Influence of hormone replacement therapy" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mariano Leal Hernández, José Abellán Alemán, Luis F. Carbonell Meseguer, Julián Díaz Fernández, Francisco Alberto García Sánchez, José María Martínez Selva" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Mariano Leal" "apellidos" => "Hernández" ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Abellán Alemán" ] 2 => array:2 [ "nombre" => "Luis F." "apellidos" => "Carbonell Meseguer" ] 3 => array:2 [ "nombre" => "Julián" "apellidos" => "Díaz Fernández" ] 4 => array:2 [ "nombre" => "Francisco Alberto" "apellidos" => "García Sánchez" ] 5 => array:2 [ "nombre" => "José" "apellidos" => "María Martínez Selva" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711845?idApp=UINPBA00004N" "url" => "/00257753/0000011400000002/v1_201307291440/S0025775300711845/v1_201307291440/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Valoración diagnóstica clínica y analítica de la trombosis venosa profunda de miembros inferiores" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "46" "paginaFinal" => "49" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Antonio-Javier Trujillo-Santos, M.<span class="elsevierStyleSup">a</span> Dolores García de Lucas, Rafael Ríos-Tamayo, Alberto Jiménez-Puente, Juan-Enrique García-Sánchez" "autores" => array:5 [ 0 => array:4 [ "nombre" => "Antonio-Javier" "apellidos" => "Trujillo-Santos" "email" => array:1 [ 0 => "trujillo@hcs.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Dolores García de Lucas" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Rafael" "apellidos" => "Ríos-Tamayo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "Alberto" "apellidos" => "Jiménez-Puente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Juan-Enrique" "apellidos" => "García-Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Unidad de Medicina Interna. Área de Medicina. Hospital Costa del Sol. Marbella. Málaga" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicios de Medicina Interna. Hospital Valle de los Pedroches. Pozoblanco. Córdoba" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Hematología. Hospital Valle de los Pedroches. Pozoblanco. Córdoba" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Unidad de Evaluación. Hospital Costa del Sol. Marbella. Málaga" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia: Dr. A.J. Trujillo-Santos. Unidad de Medicina Interna. Área de Medicina. Hospital Costa del Sol. Ctra. Nacional 340, km 187. 29600 Marbella. Málaga." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical analytic diagnostic assessment of deep vein thrombosis of lower limbs" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-04-14" "fechaAceptado" => "1999-09-09" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221140" "palabras" => array:2 [ 0 => "Trombosis venosa profunda" 1 => "Dímero-D" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El diagnóstico de la trombosis venosa profunda (TVP) de miembros inferiores havariado en los últimos años. El objetivo del estudio fue analizar la capacidad diagnóstica de lacombinación de datos clínicos y epidemiológicos y valores plasmáticos de dímero-D en dichaentidad.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se revisaron los datos epidemiológicos y clínicos (síntomas y signos), antecedentespersonales y familiares y valores plasmáticos o positividad del dímero-D correspondientesal momento del ingreso, en las historias clínicas de 108 pacientes a los que se realizóuna flebografía ante la sospecha de TVP de miembros inferiores.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La flebografía intravenosa fue positiva en 76 casos (70,37%). Mediante regresiónlogística se obtuvo un modelo predictivo del diagnóstico de TVP que combina datos clinicoepidemiológicosy el valor del dímero-D.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La combinación de la concentración plasmática del dímero-D y el dolor en el territoriodel sistema venoso profundo es útil como aproximación diagnóstica inicial de la TVP demiembros inferiores.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Diagnosis of deep-vein thrombosis (DVT) of lower limbs has changed in recentyears. The objective of our study was to analyze the diagnostic accuracy of a combination of clinicaland epidemiological data and the D-Dimer plasma levels in this entity.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Clinical (symptoms and signs) and epidemiological data, personal and familyhistory, and D-dimer plasma levels or positivity were reviewed, on the admittance, in 108patients to whom a phlebography was performed due to a suspected DVT.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Phlebography was positive in 76 cases (70.37%). Logistic regression analysis determineda prediction model of the diagnostic of DVI including a combination of both D-dimer plasmalevels or positivity and pain along the deep venous involved area.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Combination of D-dimer testing and pain along the distribution of the deep venousarea is useful as an initial diagnostic approach to the DVI of the lower limbs.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:19 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Does this patient have deep vein thrombosis?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "S.S. Anand" 1 => "P.S. Wells" 2 => "D. 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Wheeler" 2 => "R.I. Goldberg" 3 => "D.W. Hosmer" 4 => "N.A. Patwardhan" 5 => "B. Jovanovic" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1991" "volumen" => "151" "paginaInicial" => "933" "paginaFinal" => "938" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2025141" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Hirsh" 1 => "R. Raschke" 2 => "T. 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"referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Problems of acute deep venous thrombosis, I: the interpretation of signs and symptoms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K. Haeger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Angiology" "fecha" => "1969" "volumen" => "20" "paginaInicial" => "219" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5778113" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of deep venous thrombosis in the outpatient by venography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T. O'Donnell" 1 => "W. Abbott" 2 => "C. Athanasoulis" 3 => "V. Millan" 4 => "A. 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