array:23 [ "pii" => "S1699885512000852" "issn" => "16998855" "doi" => "10.1016/j.patol.2012.08.003" "estado" => "S300" "fechaPublicacion" => "2013-04-01" "aid" => "202" "copyright" => "SEAP y SEC" "copyrightAnyo" => "2012" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2013;46:90-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1731 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 1334 "PDF" => 388 ] ] "itemSiguiente" => array:18 [ "pii" => "S1699885512000803" "issn" => "16998855" "doi" => "10.1016/j.patol.2012.06.003" "estado" => "S300" "fechaPublicacion" => "2013-04-01" "aid" => "197" "copyright" => "SEAP y SEC" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2013;46:93-100" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3665 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 3098 "PDF" => 556 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artículo breve</span>" "titulo" => "Fibromixoma plexiforme del antro gástrico: descripción de 2 casos y revisión de la literatura" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "93" "paginaFinal" => "100" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Plexiform fibromyxoma of the gastric antrum: a report of 2 cases and a review of the literature" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1130 "Ancho" => 1583 "Tamanyo" => 507579 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Las células tumorales son fusiformes y se disponen en el seno de una matriz mixoide (200×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Ana M. Vallejo-Benítez, Judith Suárez-Aguado, Montserrat Mora-Cabezas, Teresa Aramendi, Margarita Gimeno, José Salas, Ricardo González-Cámpora" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Ana M." "apellidos" => "Vallejo-Benítez" ] 1 => array:2 [ "nombre" => "Judith" "apellidos" => "Suárez-Aguado" ] 2 => array:2 [ "nombre" => "Montserrat" "apellidos" => "Mora-Cabezas" ] 3 => array:2 [ "nombre" => "Teresa" "apellidos" => "Aramendi" ] 4 => array:2 [ "nombre" => "Margarita" "apellidos" => "Gimeno" ] 5 => array:2 [ "nombre" => "José" "apellidos" => "Salas" ] 6 => array:2 [ "nombre" => "Ricardo" "apellidos" => "González-Cámpora" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885512000803?idApp=UINPBA00004N" "url" => "/16998855/0000004600000002/v2_201304200444/S1699885512000803/v2_201304200444/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699885512000864" "issn" => "16998855" "doi" => "10.1016/j.patol.2012.07.006" "estado" => "S300" "fechaPublicacion" => "2013-04-01" "aid" => "203" "copyright" => "SEAP y SEC" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2013;46:83-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 4488 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 3847 "PDF" => 635 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artículo breve</span>" "titulo" => "Leiomiosarcoma con patrón fusocelular y epitelioide en cuerpo del páncreas. Utilidad de la inmunohistoquímica en el diagnóstico diferencial de las neoplasias mesenquimales pancreáticas" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "83" "paginaFinal" => "89" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Leiomyosarcoma with spindle and epithelioid pattern in the pancreatic body. The role of immunohistochemistry in the differential diagnosis of mesenchymal pancreatic tumours" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1350 "Ancho" => 1800 "Tamanyo" => 513571 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A) Desmina positiva +++ en células tumorales fusocelulares y epitelioides, 400×. B) Tinción focal para miosina de músculo liso + en células aisladas tumorales, 400×. C) Miogenina negativa en células tumorales de leiomiosarcoma, 400×. D) CD99 con positividad moderada citoplasmática en las células neoplásicas. E) Tinción positiva focal para CK (AE1/AE3) predominante en células tumorales epitelioides del leiomiosarcoma, 200×. F) Inmunotinción negativa para CD117 en las células neoplásicas del leiomiosarcoma. Se observa tinción positiva en mastocito, 400×.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Isidro Machado, Alfonso García-Fadrique, Jesús Santos, Julia Cruz, Ana Marhuenda, Concepción Gómez i Gavara, Luis Rubio, Rafael Estevan" "autores" => array:8 [ 0 => array:2 [ "nombre" => "Isidro" "apellidos" => "Machado" ] 1 => array:2 [ "nombre" => "Alfonso" "apellidos" => "García-Fadrique" ] 2 => array:2 [ "nombre" => "Jesús" "apellidos" => "Santos" ] 3 => array:2 [ "nombre" => "Julia" "apellidos" => "Cruz" ] 4 => array:2 [ "nombre" => "Ana" "apellidos" => "Marhuenda" ] 5 => array:2 [ "nombre" => "Concepción" "apellidos" => "Gómez i Gavara" ] 6 => array:2 [ "nombre" => "Luis" "apellidos" => "Rubio" ] 7 => array:2 [ "nombre" => "Rafael" "apellidos" => "Estevan" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885512000864?idApp=UINPBA00004N" "url" => "/16998855/0000004600000002/v2_201304200444/S1699885512000864/v2_201304200444/es/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "An unusual presentation of colonic metastasis of adenocarcinoma of the lung" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "90" "paginaFinal" => "92" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Henry J. Carson, Stanley G. Eilers, Sudhakar Misra" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Henry J." "apellidos" => "Carson" "email" => array:1 [ 0 => "hjcmd@earthlink.net" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Stanley G." "apellidos" => "Eilers" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Sudhakar" "apellidos" => "Misra" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Mercy Hospital, Iowa City, IA, USA" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Mercy Medical Center, Cedar Rapids, IA, USA" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Gastroenterologists, P.C., Cedar Rapids, IA, USA" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Una presentación poco habitual de metástasis de adenocarcinoma de pulmón en colon" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 635 "Ancho" => 950 "Tamanyo" => 181176 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Colonic mucosa with glands of metastatic adenocarcinoma intercalating between the native crypts. The dark glands, staining positively with cytokeratin 7, are metastatic adenocarcinoma of the lung. They are also negative for cytokeratin 20 (cytokeratin 7 stain with hematoxylin counterstain, 100×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Metastasis of lung cancer to the colon is rare.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–7</span></a> In the few cases described, the histologic type of lung cancer that spreads to the colon is often squamous cell carcinoma,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,4,6,8</span></a> although adenocarcinoma has been described.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,10</span></a> The presenting symptoms are variable, and may precede or follow the diagnosis of the original lung cancer.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–3,6</span></a> Diagnosis depends on analysis of clinical signs and histology. Diagnosis benefits from the use of special stains.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,10,11</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We encountered a patient who presented with obstruction of the colon and a suspicious lung mass radiographically. While concurrent work-ups confirmed the presence of adenocarcinoma in both sites, discernment of the natural history of the disease was difficult, particularly since adenocarcinoma is so rarely described as the primary source of lung carcinoma reaching the colon, while conversely colonic adenocarcinoma often spreads to remote sites, including the lungs.</p><p id="par0015" class="elsevierStylePara elsevierViewall">We report this patient and disease in order to advance our awareness of this unusual clinical process, and to provide guidance to other physicians faced with similar unusual presentations of adenocarcinoma in two sites that compete for primary status.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">The patient was a 49-year-old white male with no significant past medical history. He presented with a chief complaint of difficulty and pain on defecation with chronic nonspecific abdominal pain. Colonoscopy revealed a circumferential, superficially ulcerated mass of the descending colon. A biopsy was performed.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The colon lesion is shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. The mucosa and colonic crypts were intact, but the submucosal lymphatics were engorged with tumor cells. The cells were round or polygonal, and arranged in clusters or groups that recapitulated glandular morphology. Immunoperoxidase stains for cytokeratin (CK) 7 and thyroid transcription factor (TTF-1) were positive, while stains for CK 20 were negative. On this basis, it was concluded that the tumor in the colon probably represented a metastasis of lung origin (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Concurrently, computed tomography of the chest showed a 3.8<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1.7<span class="elsevierStyleHsp" style=""></span>cm soft tissue density of the right hilum. Positron emission tomography confirmed increased metabolic activity at this site.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The clinician was contacted with the pathologic findings. Based on the characteristic findings consistent with metastasis of a lung tumor in the colon and the presence of a 4<span class="elsevierStyleHsp" style=""></span>cm left upper lobe lung mass, treatment was based on the assumption that the lung lesion was the primary tumor.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The patient underwent one cycle of taxol and carboplatin. He developed bilateral pleural effusions. A thoracentesis with was performed. Cytology specimens from the fluid confirmed adenocarcinoma. The lungs collapsed after the procedure and did not reinflate. The patient expired four weeks after initial diagnosis.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">Metastasis of a primary lung tumor to the colon is very rare.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1–5,8,10</span></a> Gastrointestinal symptoms may or may not lead to detection of the tumor. The metastasis is often asymptomatic<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,6</span></a> or it may be the first lesion to indicate the presence of a primary lung tumor that is subsequently found.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Alternatively, a lung carcinoma may be known, with concurrent or subsequent metastases to the colon discerned.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,10</span></a> Metastasis to the small intestine is more common than metastasis to the colon.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8–10</span></a> When symptomatic, a metastatic lung tumor may cause abdominal obstruction as in this case and others,<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3</span></a> acute abdomen,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> lower gastrointestinal hemorrhage,<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,7</span></a> pancolitis,<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> or other symptoms.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4,7</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">This patient had several characteristic findings of lung carcinoma that metastasizes to the colon. He was unusual, however, in that he had concurrent indications of both lung and colon tumors. The process of determining which tumor was primary, and of providing a meaningful treatment and prognosis for this patient, were the principle challenges of this case.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Typically patients develop lung carcinoma first. The primary disease is treated first, and subsequent metastases are treated later.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,6,8</span></a> The present patient differs from most previously reported cases in the simultaneous presentation of lung and colon tumors, and in the histologic type of his tumor. Most reported cases of lung cancer that spreads to the colon are derived from squamous cell origin.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,3,6,8</span></a> The histological type of squamous cell carcinoma is a strong indication that the tumor is not of colonic origin. Cases of undifferentiated large cell carcinoma are reported, which could be a variant of adenocarcinoma of the lung.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,7</span></a> A cancer that maintains such distinctive histologic and immunophenotypic features of adenocarcinoma of the lung as seen in the present patient is quite unusual.</p><p id="par0060" class="elsevierStylePara elsevierViewall">Immunoperoxidase stains can aid immensely in establishing the presence of metastasis.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,10</span></a> In a man, the CK 7 positive, CK 20 negative phenotype of adenocarcinoma is most appropriate for a primary lung carcinoma. In a woman, other possible tumors with this phenotype include adenocarcinomas of the breast, ovary, and endometrium. Squamous cell carcinoma of the uterine cervix may also express this phenotype, although the histologic appearance of the tumor will typically differ from adenocarcinoma. In such cases, it may be useful to add a TTF-1 stain to the diagnosis.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> This stain can separate adenocarcinoma of the lung, which is usually positive for TTF-1, from other candidate adenocarcinomas, which are usually negative for this marker.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Treatment of these patients may consist of surgical debulking of the colon mass<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,5,8</span></a> or, as for this patient, systemic treatment with chemotherapy.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Prognosis is variable. Survival may be comparable to the primary lung disease after resection of the colon metastasis,<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6,8</span></a> but it may be short.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,5,10</span></a> Recurrence of bowel metastases may complicate the clinical course.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However, survival over a year has been reported in spite of advanced stage.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,8</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">This patient demonstrates a rare presentation of a metastatic adenocarcinoma of the lung to the colon. It is possible that this histologic variant of the carcinoma may have contributed to his poor prognosis. The case thus demonstrates the value of establishing the presence of metastasis in a colon lesion, its histologic type, and using immunohistochemistry to establish or confirm the site of the primary tumor.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Ethical responsibilities</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Protection of human and animal subjects</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Confidentiality of data</span><p id="par0080" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data and that all the patients included in the study have received sufficient information and have given their informed consent in writing to participate in that study.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Right to privacy and informed consent</span><p id="par0085" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicts of interest</span><p id="par0090" class="elsevierStylePara elsevierViewall">The authors have no conflicts of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:2 [ "identificador" => "xres91124" "titulo" => "Abstract" ] 1 => array:2 [ "identificador" => "xpalclavsec78327" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xres91125" "titulo" => "Resumen" ] 3 => array:2 [ "identificador" => "xpalclavsec78328" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Ethical responsibilities" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Right to privacy and informed consent" ] ] ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Conflicts of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-06-25" "fechaAceptado" => "2012-08-20" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec78327" "palabras" => array:5 [ 0 => "Colon" 1 => "Lung" 2 => "Adenocarcinoma" 3 => "Metastasis" 4 => "Prognosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec78328" "palabras" => array:5 [ 0 => "Colon" 1 => "Pulmón" 2 => "Adenocarcinoma" 3 => "Metástasis" 4 => "Pronóstico" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A 49-year-old male presented with difficult, painful defecation. Colonoscopy revealed a circumferential mass of the descending colon. A biopsy showed submucosal lymphatics engorged with tumor cells. Immunoperoxidase stains suggested that the tumor probably represented a metastasis from the lung. Computed tomography of the chest showed a right lung mass. The patient died four weeks after initial diagnosis. The primary tumor was an adenocarcinoma of the lung which had metastasized to the colon. This is unusual compared to the more-common metastatic squamous cell carcinoma. This case demonstrates the importance of recognizing the presence of metastasis in a colonic lesion, establishing its histologic type and identifying the site of the primary tumor using immunohistochemistry.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos el caso de un varón de 49 años con dificultad y dolor al defecar. La colonoscopia reveló la existencia de una masa circunferencial en el colon ascendente. Se realizó biopsia, que evidenció permeación de vasos linfáticos de la submucosa colónica por células tumorales con perfil inmunohistoquímico sugestivo de origen pulmonar. La tomografía axial computarizada mostró una masa en el pulmón derecho. El paciente falleció cuatro semanas tras el diagnóstico inicial. El tumor primario era un adenocarcinoma de pulmón, lo cual es raro en relación con el carcinoma epidermoide pulmonar, que afecta más comúnmente al colon. Este caso demuestra la importancia de reconocer las metástasis en colon, y el valor del estudio histológico e inmunohistoquímico para establecer el origen de una lesión colónica.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 635 "Ancho" => 950 "Tamanyo" => 181176 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Colonic mucosa with glands of metastatic adenocarcinoma intercalating between the native crypts. The dark glands, staining positively with cytokeratin 7, are metastatic adenocarcinoma of the lung. They are also negative for cytokeratin 20 (cytokeratin 7 stain with hematoxylin counterstain, 100×).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 633 "Ancho" => 950 "Tamanyo" => 174095 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Colonic mucosa with glands of metastatic adenocarcinoma intercalating between the native crypts. The dark nuclei, staining positively with TTF-1, demonstrate pulmonary origin of the metastatic adenocarcinoma (TTF-1 stain with hematoxylin counterstain, 100×).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of bronchogenic carcinoma presenting with acute abdomen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.A. Habesoglu" 1 => "K.I. Oguzulgen" 2 => "C. Ozturk" 3 => "N. Akyurek" 4 => "L. 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Brief report
An unusual presentation of colonic metastasis of adenocarcinoma of the lung
Una presentación poco habitual de metástasis de adenocarcinoma de pulmón en colon