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Liver biopsy remains a cornerstone in the assessment of diffuse liver diseases.
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Defining adequacy criteria for liver specimens avoids the impact of sampling errors.
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Many studies have defined adequacy criteria of adult liver biopsy; however, it is the first study that assesses the adequacy criteria in neonatal cholestasis (NC).
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A core length of 4 mm with a complete portal tract number (CPT) of 8±3 is considered adequate for NC activity assessment.
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A core length of 6 mm with a CPT number of 11±3 is required to assess the fibrosis stage adequately in NC.