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CLINICS 2011;66(4):673-679
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Data are presented as the mean ± SEM. (n = 8 in each group).The OVX-LN 10 and OVX-LN 50 groups were treated with daily injections of 10 and 50 mg/kg <span class="elsevierStyleInf">L</span>-NAME, respectively, from the day after ovariectomy until the beginning of the behavioral study. The animals in the OVX-Est group were treated with weekly injections of estradiol valerate (2 mg/kg; i.m.). The animals in the OVX-Est-LN 50 group were treated with weekly injections of estradiol valerate (2 mg/kg; i.m.) and received daily injections of 50 mg/kg <span class="elsevierStyleInf">L</span>-NAME. There were no significant differences in the latency between the OVX-LN 10 and OVX-LN 50 groups and the OVX group; however, the animals in the OVX-Est group had a significantly lower latency and time to reach the hidden platform than the OVX group (<span class="elsevierStyleItalic">p</span><0.001). 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