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Brain imaging tests showed no lesions and cerebrospinal fluid was normal. The complete study revealed the presence of a limited-stage small-cell lung cancer (SCLC) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The onconeural antibodies test was positive for anti-Zic4 antibodies. With the suspicion of a paraneoplastic <span class="elsevierStyleItalic">opsoclonus myoclonus</span> syndrome (OMS), a 5-day treatment with Cisplatin-Etoposide (standard in first-line) and immunosuppressive treatment with gamma globulin (0.5<span class="elsevierStyleHsp" style=""></span>mg/kg/day) was initiated. The patient showed improvement two weeks after the first cycle of chemotherapy, with complete resolution of the syndrome 3 weeks later. After 3 cycles of treatment, the patient showed a partial response.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">OMS is an extremely rare ocular motility disorder, with an incidence of 1/5,000,000<span class="elsevierStyleHsp" style=""></span>inhabitants/year. In adults, 20–40% are paraneoplastic, with SCLC being the most commonly associated neoplasm described. This case illustrates the importance of early treatment for a good neurological evolution, with antitumor therapy being the cornerstone.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Merí Abad M, Aparisi Aparisi FA, Blasco Cordellat A, Camps Herrero C. Mujer de 68 años con síndrome de ojos bailarines. Med Clin (Barc). 2019;153:475.</p>" ] ] "multimedia" => array:1 [ 0 => array:6 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 683 "Ancho" => 900 "Tamanyo" => 86272 ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/23870206/0000015300000012/v1_201912120702/S2387020619304802/v1_201912120702/en/main.assets" "Apartado" => array:4 [ "identificador" => "51820" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Images in medicine" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/23870206/0000015300000012/v1_201912120702/S2387020619304802/v1_201912120702/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020619304802?idApp=UINPBA00004N" ]
Journal Information
Vol. 153. Issue 12.
Pages 475 (December 2019)
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Vol. 153. Issue 12.
Pages 475 (December 2019)
Image in medicine
A 68-year-old woman with dancing eyes syndrome
Mujer de 68 años con síndrome de ojos bailarines
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