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Vol. 31. Issue 3.
(July - September 2024)
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Vol. 31. Issue 3.
(July - September 2024)
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Depresión mayor resistente. Terapia electroconvulsiva versus esketamina. ¿Cuál debería ser el orden? A propósito de un caso
Treatment-resistant major depression. Electroconvulsive therapy versus esketamine. Which should the order be? A case report
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Belén Urbán Antón
Corresponding author
belen.urban@alu.umh.es

Autor para correspondencia.
, Miguel Omaña Colmenares, Juan Fuertes Aparicio
Servicio de Psiquiatría, Hospital Lluís Alcanyís, Xàtiva, Valencia, España
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Resumen

Se presenta el caso de una paciente de 73 años con depresión mayor, resistente a varios antidepresivos y a la terapia electroconvulsiva, que mejoró significativamente con esketamina intranasal con una disminución de la escala MADRS de 43 puntos (depresión grave) a 18 puntos (depresión leve) a los 4 meses de tratamiento. Estos resultados plantean la duda de si ante pacientes de edad avanzada con cuadros depresivos graves resistentes a tratamiento farmacológico y con ideación suicida, deberíamos optar por la terapia electroconvulsiva o por la esketamina intranasal.

Palabras clave:
Esketamina
Terapia electroconvulsiva
Depresión resistente
Trastorno depresivo mayor
Ancianos
Abstract

We present a case of a 73-year-old woman with a treatment- resistant depression to several antidepressants and electroconvulsive therapy, who improved significantly with intranasal esketamine showing a decrease in the MADRS score from 43 points (severe depression) to 18 points (mild depression) after 4 months of treatment. These results raise the question of whether, in elderly patients suffering a treatment- resistant depression and suicidal ideation, we should choose either electroconvulsive therapy or intranasal esketamine.

Keywords:
Esketamine
Electroconvulsive therapy
Treatment-resistant depression
Major depressive disorder
Elderly

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