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Special article
Re–evaluation of the effects of high PEEP with recruitment manoeuvres versus low PEEP without recruitment manoeuvres during general anaesthesia for surgery – Protocol and statistical analysis plan for an individual patient data meta–analysis of PROVHILO, iPROVE and PROBESE
Reevaluación de los efectos de PEEP alta con maniobras de reclutamiento vs. PEEP baja sin maniobras de reclutamiento durante la anestesia general para cirugía: protocolo y plan de análisis estadístico para un metaanálisis de los datos de pacientes individuales de PROVHILO, iPROVE y PROBESE
N.S. Camposa,b, T. Bluthc, S.N.T. Hemmesd,e, J. Librerof, N. Pozog, C. Ferrandog,h, L. Balli,j, G. Mazzinarik, P. Pelosii,j, M. Gama de Abreuc, M.J. Schultzd,l,m, A. Serpa Netoa,b,d,
, on behalf of PROVHILO iPROVE and PROBESE network researches 1
Corresponding author
a Deptartment of Critical Care Medicine, Hospital Israelita Albert Einstein, São Paulo, Brazil
b Cardio-Pulmonary Department, Pulmonary Division, Instituto do Coração, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil
c Pulmonary Engineering Group, Department of Anesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
d Department of Intensive Care & Laboratory of Experimental Intensive Care and Anesthesiology (LEICA), Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
e Department of Anaesthesiology, Amsterdam UMC location ‘AMC’, University of Amsterdam, Amsterdam, The Netherlands
f Navarrabiomed-Fundación Miguel Servet, Red de Investigación en Servicios de Salud en Enfermedades Crónicas (REDISSEC), Pamplona, Navarra, Spain
g Department of Anesthesiology and Critical Care, Hospital Clinic de Barcelona, Barcelona, Spain
h CIBER of Respiratory Disease, Instituto de Salud Carlos III, Madrid, Spain
i IRCCS San Martino Policlinico Hospital, Genoa, Italy
j Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy
k Department of Anesthesiology and Pain Medicine, Hospital de Manises, Valencia, Spain
l Research Group in Perioperative Medicine, Instituto de Investigación Sanitaria La Fe, Valencia, Spain
m Mahidol Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
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