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Case report
Marfan syndrome in a term-pregnant woman with aortic root dilatation between 40 and 45mm
Síndrome de Marfan en gestante a término con dilatación de la raíz aórtica entre 40 y 45mm
D.R. Delgado García
Corresponding author
dadegar@gmail.com

Corresponding author.
, P. Latorre Andreu, B. Fernández Tomás, M.I. Tébar Cuesta
Servicio de Anestesiología y Reanimación, Hospital 12 de Octubre, Madrid, Spain
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including echocardiography to assess the size of the aortic root&#44; which&#44; if greater that 40<span class="elsevierStyleHsp" style=""></span>mm&#44; is at high risk of rupture&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Some recent guidelines recommend that women with SM and an aortic root diameter<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mm should avoid pregnancy&#44; or should undergo ascending aorta replacement surgery before conception if the aorta measures<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>mm&#46; The medical treatment of choice is beta-blockers&#44; and labetalol or metoprolol &#40;Food and Drug Administration category <span class="elsevierStyleSmallCaps">C</span>&#41; in pregnant women&#44; which should not be withdrawn at any time &#40;irrespective of whether the birth is by caesarean vaginal delivery&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0015" class="elsevierStylePara elsevierViewall">We report the case of a 32-year-old female weighing 77<span class="elsevierStyleHsp" style=""></span>kg&#44; height 179<span class="elsevierStyleHsp" style=""></span>cm&#44; diagnosed with SM in 2014&#46; She exhibited no cardiovascular symptoms&#44; although echocardiograpy and magnetic resonance angiography showed a dilated ascending aorta which&#44; between 2014 and 2018&#44; had increased in diameter from 38 to 41<span class="elsevierStyleHsp" style=""></span>mm before pregnancy to 41 to 42<span class="elsevierStyleHsp" style=""></span>mm towards the end of pregnancy&#46; She was treated with atenolol&#44; which was replaced with metoprolol during pregnancy&#44; with good blood pressure control&#46; Her family history was significant for her father&#44; who had been diagnosed as marfanoid habitus and was undergoing follow-up for aortic aneurysm&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The mode of delivery was decided by a multidisciplinary team of cardiologists&#44; obstetricians and anaesthesiologists&#46; After evaluating the case&#44; the team recommended scheduled caesarean section under general anaesthesia to avoid the risk associated with physiological changes related to vaginal delivery&#46; General anaesthesia was chosen for 2 reasons&#58; to facilitate haemodynamic management&#59; and because the possible presence of dural ectasia&#44; which had not previously been ruled out by magnetic resonance&#44; could result in ineffective spinal anaesthesia&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient underwent scheduled caesarean section at 38 weeks and 4 days of gestation&#46; After starting standard monitoring&#44; the radial artery was cannulated for continuous blood pressure monitoring&#44; given the importance of avoiding haemodynamic instability&#46; Following this&#44; preoxygenation and rapid sequence induction of general anaesthesia was performed with 300<span class="elsevierStyleHsp" style=""></span>mg sodium thiopental&#44; remifentanil infusion of around 0&#46;08&#8211;0&#46;1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;min and 75<span class="elsevierStyleHsp" style=""></span>mg of succinylcholine&#46; Intubation was successful at the first attempt using the Airtraq<span class="elsevierStyleSup">&#174;</span> airway &#40;Prodol Meditec&#44; Vizcaya&#44; Spain&#41;&#44; and a central venous line was inserted through the right internal jugular vein&#46; Anaesthesia was maintained with sevoflurane at a MAC of around 1&#46;6&#44; together with O<span class="elsevierStyleInf">2</span>&#47;air&#44; neuromuscular relaxation with rocuronium&#44; and continuous perfusion of remifentanil at 0&#46;1<span class="elsevierStyleHsp" style=""></span>&#956;g&#47;kg&#47;min&#46; Paediatrics had already been warned that the infant might need ventilatory support due to the use of opiates&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">After delivery&#44; a bolus of 3<span class="elsevierStyleHsp" style=""></span>IU oxytocin was administered&#44; followed by continuous infusion of 1&#46;26<span class="elsevierStyleHsp" style=""></span>IU&#47;h over the following 24<span class="elsevierStyleHsp" style=""></span>h&#46; The patient remained haemodynamically stable during the procedure&#44; with well-controlled blood pressure&#46; The infant had an Apgar score of 3 at 1<span class="elsevierStyleHsp" style=""></span>min of life&#44; 7 at 5<span class="elsevierStyleHsp" style=""></span>min&#44; and 10 at 10<span class="elsevierStyleHsp" style=""></span>min of life&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Non-steroidal anti-inflammatories were given for postoperative analgesia&#44; and bilateral&#44; ultrasound-guided transverse abdominis plane block was performed with 15-ml of 0&#46;25&#37; levobupivacaine&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">After reversing neuromuscular blockade with sugammadex&#44; the patient was extubated in the operating room and then transferred to the postoperative care unit for monitoring&#46; She remained haemodynamically stable&#44; with good pain control&#44; good uterine contraction and urine output&#44; and was discharged to the ward 24<span class="elsevierStyleHsp" style=""></span>h after the intervention&#46; The puerperium was uneventful&#44; with a 1-month follow-up echocardiogram showing no progression of ascending aorta dilation&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">The best approach to anaesthesia management in pregnant women with MS has yet to be defined&#46; As mentioned above&#44; MS is characterised&#44; among other manifestations&#44; by musculoskeletal involvement&#44; together with dural ectasia and dilatation of the aortic root&#46; In the absence of treatment &#40;beta-blockers&#41;&#44; the aortic dilation tends to worsen over time&#46; Pregnancy can accelerate this process due to its effect on connective tissue &#40;more fragile vascular wall&#41; and on haemodynamics&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> These changes begin in the first and second trimesters&#44; but the third is the period of maximum stress&#44; with an increase in heart rate&#44; stroke volume&#44; blood volume and blood pressure&#46;<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#44;4</span></a> The pregnancy-induced increase in cardiac output reaches a peak immediately after delivery because of the effects of labour pain and autotransfusion secondary to uterine contractions&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Therefore&#44; both pregnancy and childbirth in women with MS can be considered a risk situation for aortic dissection&#44; especially when the aortic root is<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mm&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;4&#8211;6</span></a> The target mean arterial pressure should be about 65&#8211;70<span class="elsevierStyleHsp" style=""></span>mmHg&#44; or the lowest blood pressure tolerated by the patient&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Due to changes in the connective tissue of the aortic wall&#44; all pregnant women with MS can be considered to be at risk of aortic dissection&#44; regardless of the size of the aortic diameter&#46; However&#44; a diameter<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>40<span class="elsevierStyleHsp" style=""></span>mm is associated with low risk &#40;if beta-blockers are administered&#41; and<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>45<span class="elsevierStyleHsp" style=""></span>mm with very high risk<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a>&#59; but&#44; what if the aorta is between 40 and 45<span class="elsevierStyleHsp" style=""></span>mm&#63; Although there is a tendency towards standardisation in the literature&#44; these cases should be approached individually and considered together with other factors&#46; One such factor in the ratio of the aortic diameter to the body surface&#44; particularly in small women&#44; where diameters<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>27<span class="elsevierStyleHsp" style=""></span>mm&#47;m<span class="elsevierStyleSup">2</span> indicate a high risk of dissection&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Another factor to consider is the existence of a familial or personal history of aneurysm or aortic dissection&#46; It goes without saying that the risk will increase if the diameter of the aortic root is closer to 45<span class="elsevierStyleHsp" style=""></span>mm than 40<span class="elsevierStyleHsp" style=""></span>mm&#46; Finally&#44; an increase in aortic diameter<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>mm during pregnancy has been associated with an increased risk of dissection&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> What is clear is the need for thorough follow-up with imaging tests during and after pregnancy to monitor the cardiovascular system and the possible progression of dilation&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The choice of delivery mode&#44; leaving aside any strictly obstetric indications&#44; will be made based on the patient&#39;s history and the diameter of the aortic root&#46; In women with<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>45-mm aortic dilatation&#44; caesarean section&#44; and even pre-pregnancy aortic replacement appear to be indicated&#46; In patients with 40&#8211;45<span class="elsevierStyleHsp" style=""></span>mm aortic dilatation&#44; as in our case&#44; the option of caesarean section should be weighed up by a multidisciplinary team on a case by case basis&#44; taking into consideration the foregoing factors&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;4</span></a> If vaginal delivery is indicated&#44; epidural analgesia should be administered early to relieve pain in the second stage of labour and thus reduce the risk of blood pressure peaks that can induce aortic wall dissection&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Suspicion of difficult or impossible epidural puncture could be another reason for suggesting a caesarean section&#46; Mindful of the repeated recommendations in the literature regarding the need for strict control of blood pressure in these patient&#44; we decided to perform a caesarean with general anaesthesia&#44; which would greatly facilitate the management of sudden peaks in cardiac output that could endanger the patient&#39;s life&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">The choice of anaesthesia for a caesarean section in a woman with MS and aortic dilatation is based on several key considerations&#44; although there is no evidence in the literature to show the superiority of one anaesthesia technique over any other&#46; The first consideration is that general anaesthesia is more likely to facilitate good haemodynamic control&#46; Assuming that these patients have already been prescribed beta-blocker therapy&#44; the hypertensive response to laryngoscopy during the induction of general anaesthesia could be alleviated in several ways&#44; including the administration of drugs&#44; particularly remifentanil&#44; an ultra-short-acting&#44; relatively safe option&#46; If used&#44; the paediatric team should be notified that the newborn could present respiratory depression&#44; which in the case of remifentanil will usually revert spontaneously or with the administration of naloxone&#46; Another method of reducing the haemodynamic response to laryngoscopy is the use of videolaryngoscopy&#46; We used the Airtraq&#44; which in comparative studies with a Macintosh blade has shown greater ease of insertion and less haemodynamic involvement during laryngoscopy&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> Given that avoiding hypertension is more important than avoiding mild hypotension&#44; it could be argued this haemodynamic goal is more easily attained using a neuraxial technique than general anaesthesia&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> However&#44; these patients can present complicating factors&#44; such as dural ectasia&#44; which some series estimate to occur in 92&#37; of MS patients&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Due to this&#44; the intrathecal spread of the anaesthetic can be unpredictable and inadequate&#44; resulting in the failure of the technique&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> Epidural analgesia and anaesthesia in patients with moderate to severe dural ectasia is not recommended due to the increased risk of accidental dural puncture&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> However&#44; experts now agree that epidural anaesthesia &#40;at titrated doses&#41; should be considered the technique of choice&#44; provided the caesarean is scheduled&#46; This technique gives good perioperative haemodynamic and analgesic control&#44; and its effect is more predictable than intradural techniques&#44; except in cases of haemodynamic decompensation&#46; The degree of dural ectasia can be measured by magnetic resonance&#46; However&#44; if it has not been performed&#44; as was the case in our patient&#44; it must be assumed to be present&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">In conclusion&#44; it is best to approach the anaesthetic and obstetrical management of pregnant women with SM and aortic dilatation &#40;particularly 40&#8211;45<span class="elsevierStyleHsp" style=""></span>mm diameter&#41; on a case by case basis&#46; Management should be undertaken by a multidisciplinary team that will decide the best and safest delivery mode for both the mother and the foetus&#46; The type of anaesthesia used depends on the experience of the anaesthesiologist and the patient&#39;s status and comorbidities&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Conflicts of interest</span><p id="par0070" class="elsevierStylePara elsevierViewall">None&#46;</p></span></span>"
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            0 => "Marfan syndrome"
            1 => "Aortic root dilation"
            2 => "Caesarean section"
            3 => "Anaesthesia"
            4 => "Obstetrics"
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            0 => "S&#237;ndrome de Marfan"
            1 => "Dilataci&#243;n ra&#237;z a&#243;rtica"
            2 => "Ces&#225;rea"
            3 => "Anestesia"
            4 => "Obstetricia"
            5 => "Anestesia obst&#233;trica"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Marfan syndrome is a hereditary connective tissue disorder&#46; The main cause of mortality in these patients is due to cardiovascular complications related to dilation of an aneurysm and dissection of the aortic root&#44; a situation that increases their risk due to the physiological changes that occur during pregnancy&#44; childbirth and puerperium&#46; The case is presented of a pregnant woman with Marfan syndrome and aortic root dilatation of 42<span class="elsevierStyleHsp" style=""></span>mm&#46; The issues are discussed&#44; such as the mode of delivery &#40;vaginal delivery vs&#46; caesarean section&#41; depending on the aortic root diameter or the choice of type of anaesthesia &#40;general vs&#46; neuraxial&#41; in these cases&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El s&#237;ndrome de Marfan es un trastorno hereditario del tejido conectivo&#46; La principal causa de mortalidad en estas pacientes es debida a complicaciones cardiovasculares relacionadas con dilataci&#243;n aneurism&#225;tica de la ra&#237;z a&#243;rtica y disecci&#243;n de la misma&#44; situaci&#243;n que aumenta su riesgo con los cambios fisiol&#243;gicos que ocurren durante el embarazo&#44; el parto y el puerperio&#46; Presentamos el caso de una paciente embarazada que presentaba s&#237;ndrome de Marfan y dilataci&#243;n de la ra&#237;z a&#243;rtica de 42<span class="elsevierStyleHsp" style=""></span>mm&#44; e intentamos arrojar luz sobre temas como son la v&#237;a de parto &#40;parto vaginal vs&#46; ces&#225;rea&#41; en funci&#243;n del di&#225;metro a&#243;rtico o la elecci&#243;n del tipo de anestesia &#40;general vs&#46; neuroaxial&#41; en estos casos&#46;</p></span>"
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        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Delgado Garc&#237;a DR&#44; Latorre Andreu P&#44; Fern&#225;ndez Tom&#225;s B&#44; T&#233;bar Cuesta MI&#46; S&#237;ndrome de Marfan en gestante a t&#233;rmino con dilataci&#243;n de la ra&#237;z a&#243;rtica entre 40 y 45<span class="elsevierStyleHsp" style=""></span>mm&#46; Rev Esp Anestesiol Reanim&#46; 2019&#59;66&#58;49&#8211;52&#46;</p>"
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ISSN: 23411929
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos