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Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) A case of brain and leptomeningeal metastases from urothelial carcinoma of the b...
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Vol. 33. Issue 5.
Pages 290-292 (September - October 2014)
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Vol. 33. Issue 5.
Pages 290-292 (September - October 2014)
Clinical note
A case of brain and leptomeningeal metastases from urothelial carcinoma of the bladder
Un caso de metástasis cerebrales y leptomeníngeas de un carcinoma urotelial de vejiga
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S. Erhamamcıa,
Corresponding author
sevaler@yahoo.com

Corresponding author.
, M. Reyhana, N. Altinkayab
a Department of Nuclear Medicine, Faculty of Medicine, Baskent University, Ankara, Turkey
b Department of Radiology, Faculty of Medicine, Baskent University, Ankara, Turkey
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Abstract

Brain metastases are unusual from urethelial carcinoma of bladder and particularly the occurrence of leptomeningeal metastases is extremely rare, with few cases described in the literature. We present a case of a 45-year-old man with a rare brain metastases as the first metastatic manifestation secondary to urethelial carcinoma of bladder followed by leptomeningeal metastases without any other organ involvement. Eleven months after the diagnosis of high-grade urethelial carcinoma of bladder (T2N0M0), the patient was detected having brain metastases by MRI. FDG PET/CT images for the metastatic evaluation showed no abnormal FDG uptake elsewhere in the body except the brain. Histopathology examination from brain lesion demonstrated the cerebral lesion to be a metastatic urothelial carcinoma. Two months later, the patient was diagnosed to have leptomeningeal metastases by MRI. Our patient's condition gradually worsened, and he died 3 months after the diagnosis of leptomeningeal metastases.

Keywords:
Urothelial bladder carcinoma
Brain metastases
Leptomeningeal metastases
FDG
PET/CT
Resumen

Las metástasis cerebrales del carcinoma urotelial de vejiga son poco habituales y, en particular, las metástasis leptomeníngeas son extremadamente raras, siendo pocos los casos descritos en la literatura. Presentamos un hombre de 45 años con metástasis cerebral como primera manifestación secundaria de un carcinoma urotelial de vejiga seguido de metástasis leptomeníngeas sin otra afectación sistémica. Once meses después del diagnóstico de un carcinoma urotelial de vejiga (T2N0M0), se detectaron metástasis cerebrales por RM. El estudio de estadificación con FDG PET/TC no demostró captación anormal en otra parte del cuerpo a excepción del cerebro. El examen histopatológico de una lesión cerebral demostró metástasis del carcinoma urotelial. Dos meses después, una RM descubrió metástasis leptomeníngeas. La situación clínica del paciente se deterioró gradualmente, y falleció 3 meses después del diagnóstico de las metástasis leptomeníngeas.

Palabras clave:
Carcinoma urotelial de vejiga
Metástasis cerebral
Metástasis leptomeníngea
FDG
PET/TC

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