Article
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
array:23 [ "pii" => "S2253808918300107" "issn" => "22538089" "doi" => "10.1016/j.remnie.2018.03.002" "estado" => "S300" "fechaPublicacion" => "2019-03-01" "aid" => "980" "copyrightAnyo" => "2018" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:118-20" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6 "formatos" => array:2 [ "HTML" => 2 "PDF" => 4 ] ] "Traduccion" => array:1 [ "es" => array:18 [ "pii" => "S2253654X17302779" "issn" => "2253654X" "doi" => "10.1016/j.remn.2018.02.008" "estado" => "S300" "fechaPublicacion" => "2019-03-01" "aid" => "980" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:118-20" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 174 "formatos" => array:2 [ "HTML" => 120 "PDF" => 54 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagen de interés</span>" "titulo" => "Detección de tejido paratiroideo hiperfuncionante mediante PET/TC con <span class="elsevierStyleSup">18</span>F-fluorocolina" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "118" "paginaFinal" => "120" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Detection of hyperfunctioning parathyroid tissue by <span class="elsevierStyleSup">18</span>F-Fluorocholine PET/CT" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 680 "Ancho" => 1400 "Tamanyo" => 76756 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En el paciente con hiperparatiroidismo bioquímico persistente (PTH: 177<span class="elsevierStyleHsp" style=""></span>pg/ml y calcio: 11,5<span class="elsevierStyleHsp" style=""></span>mg/dl) se realizaron exploraciones de imagen adicionales 12 meses después de la cirugía. Se realizó gammagrafía tiroidea (A) y paratiroidea (B1 y B2), siguiendo el mismo protocolo que en la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>. La gammagrafía paratiroidea se completó con una adquisición SPECT/TC (C) en la que, al igual que en el estudio planar, no hubo evidencia de hiperfunción paratiroidea. Del mismo modo, se realizaron 2 ecografías cervicales (a los 13 y 24 meses de la cirugía, respectivamente), que no mostraron lesiones significativas. En vista de la persistencia de la alteración bioquímica y de la negatividad de los estudios morfo-funcionales convencionales, se decidió realizar una PET/TC con <span class="elsevierStyleSup">18</span>F-fluorocolina (32 meses después de la cirugía, <a class="elsevierStyleCrossRef" href="#fig0015">fig. 3</a>).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D. Villasboas-Rosciolesi, A. García-Burillo, O. González-López, E. Caubet-Busquet, J. Castell-Conesa" "autores" => array:5 [ 0 => array:2 [ "nombre" => "D." "apellidos" => "Villasboas-Rosciolesi" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "García-Burillo" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "González-López" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Caubet-Busquet" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Castell-Conesa" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2253808918300107" "doi" => "10.1016/j.remnie.2018.03.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300107?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X17302779?idApp=UINPBA00004N" "url" => "/2253654X/0000003800000002/v1_201903020653/S2253654X17302779/v1_201903020653/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S2253808918301034" "issn" => "22538089" "doi" => "10.1016/j.remnie.2018.10.012" "estado" => "S300" "fechaPublicacion" => "2019-03-01" "aid" => "1000" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:121-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 19 "formatos" => array:2 [ "HTML" => 17 "PDF" => 2 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "Digital PET/CT vs. analog PET/CT in a parathyroid gland study with <span class="elsevierStyleSup">18</span>F-Fluorocholine" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "122" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "PET/TC digital vs. PET/TC analógico en un estudio de glándulas paratiroideas con <span class="elsevierStyleSup">18</span>F-fluorocolina" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 932 "Ancho" => 1750 "Tamanyo" => 159147 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">a) Planar and tomographic images (SPECT/TC) with <span class="elsevierStyleSup">99m</span>Tc-MIBI of the cervicothoratic region performed at 150<span class="elsevierStyleHsp" style=""></span>min: hiperfunctioning parathyroid tissue is not detected. b) <span class="elsevierStyleSup">18</span>F-fluorocholina PET/CT performed in an analog system (GEMINI): discrete diffuse radiotracer uptake at the lower pole of the left thyroid lobe without morphological alterations. c) <span class="elsevierStyleSup">18</span>F-fluorocholina PET/CT performed in a digital system (VEREOS): a 6<span class="elsevierStyleHsp" style=""></span>mm nodule with focal radiotracer uptake, located posterior in the lower pole of the left thyroid lobe, suggestive of a parathyroid adenoma, is observed.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "D.A. López-Mora, M. Estorch, F. Fuentes-Ocampo, J.I. Pérez García, A. Moral, I. Carrio" "autores" => array:6 [ 0 => array:2 [ "nombre" => "D.A." "apellidos" => "López-Mora" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Estorch" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Fuentes-Ocampo" ] 3 => array:2 [ "nombre" => "J.I." "apellidos" => "Pérez García" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "Moral" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Carrio" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X18301008" "doi" => "10.1016/j.remn.2018.06.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18301008?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918301034?idApp=UINPBA00004N" "url" => "/22538089/0000003800000002/v1_201903020621/S2253808918301034/v1_201903020621/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2253808918300533" "issn" => "22538089" "doi" => "10.1016/j.remnie.2018.07.001" "estado" => "S300" "fechaPublicacion" => "2019-03-01" "aid" => "994" "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:116-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 14 "formatos" => array:2 [ "HTML" => 12 "PDF" => 2 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "<span class="elsevierStyleSup">99m</span>Tc-MAG3 SPECT/CT in a case of urolithiasis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "116" "paginaFinal" => "117" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Spect/Tc con <span class="elsevierStyleSup">99m</span>Tc-MAG3 en un caso de urolitiasis" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1635 "Ancho" => 1500 "Tamanyo" => 133183 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) First 16<span class="elsevierStyleHsp" style=""></span>min acquisition. Ascending scintigraphic curves bilaterally which are typical of obstruction. Blue curve right kidney, red curve left kidney. (B) Second 16<span class="elsevierStyleHsp" style=""></span>min acquisition, administration of furosemide at minute 0 (F0) is performed. It is observed how the curves descend bilaterally after diuretic stimulation. Blue curve right kidney, red curve left kidney.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.A. Ochoa-Figueroa, A. Davidsson, V. Sánchez-Rodríguez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "M.A." "apellidos" => "Ochoa-Figueroa" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Davidsson" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Sánchez-Rodríguez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X1830074X" "doi" => "10.1016/j.remn.2018.05.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X1830074X?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300533?idApp=UINPBA00004N" "url" => "/22538089/0000003800000002/v1_201903020621/S2253808918300533/v1_201903020621/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting image</span>" "titulo" => "Detection of hyperfunctioning parathyroid tissue by PET/CT with <span class="elsevierStyleSup">18</span>F-Fluorocholine" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "118" "paginaFinal" => "120" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "D. Villasboas-Rosciolesi, A. García-Burillo, O. González-López, E. Caubet-Busquet, J. Castell-Conesa" "autores" => array:5 [ 0 => array:4 [ "nombre" => "D." "apellidos" => "Villasboas-Rosciolesi" "email" => array:1 [ 0 => "diego.villasboas@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "A." "apellidos" => "García-Burillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "O." "apellidos" => "González-López" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Caubet-Busquet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "J." "apellidos" => "Castell-Conesa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Nuclear, Hospital Universitari Vall d’Hebron, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Cirugía Endocrina, Hospital Universitari Vall d’Hebron, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Detección de tejido paratiroideo hiperfuncionante mediante PET/CT con <span class="elsevierStyleSup">18</span>F-Fluorocolina" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 680 "Ancho" => 1400 "Tamanyo" => 76714 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Further imaging studies in the patient with persistent biochemical hyperparathyroidism (PTH: 177<span class="elsevierStyleHsp" style=""></span>pg/mL, calcium 11.5<span class="elsevierStyleHsp" style=""></span>mg/dL), 12 months after surgery were performed. Thyroid (A) and parathyroid (B1 and B2) scintigraphy were performed, same protocol as in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. A study was completed with acquisition of SPECT/CT (C), in which, as in planar images, no parathyroid hyperfunction was evident. Likewise, two cervical ultrasounds were performed (at 13 and 24 months after surgery) that did not show significant lesions.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In view of the persistence of the biochemical alteration and the negativity of the conventional morpho-functional studies, it was decided to perform a PET/CT study with <span class="elsevierStyleSup">18</span>F-Fluorocholine (32 months after the surgery, <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 39-year-old man being studied for cloxacillin allergy, without previous history, showed hypercalcemia (11.9<span class="elsevierStyleHsp" style=""></span>mg/dL). An extended analytical study showed the following values: calcium 11.9<span class="elsevierStyleHsp" style=""></span>mg/dL; phosphate: 3.1<span class="elsevierStyleHsp" style=""></span>mg/dL; calcidiol 21.8<span class="elsevierStyleHsp" style=""></span>ng/mL; paratirine (PTH) 144<span class="elsevierStyleHsp" style=""></span>pg/mL; urinary calcium 11.8<span class="elsevierStyleHsp" style=""></span>mg/dL; and urinary calcium excretion 177<span class="elsevierStyleHsp" style=""></span>mg/24<span class="elsevierStyleHsp" style=""></span>h. Upon the suspicion of primary hyperparathyroidism (PPH), a cervical ultrasound was requested that was inconclusive (adenopathy versus right parathyroid gland), and parathyroid scintigraphy (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) without evidence of parathyroid hyperfunction.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Minimally invasive surgery was performed with a biopsy taken from both right parathyroid glands (based on the sonographic findings). The intraoperative monitoring of PTH was: basal 175<span class="elsevierStyleHsp" style=""></span>pg/mL, 5<span class="elsevierStyleHsp" style=""></span>min 205<span class="elsevierStyleHsp" style=""></span>pg/mL and 10<span class="elsevierStyleHsp" style=""></span>min 220<span class="elsevierStyleHsp" style=""></span>pg/mL. The histopathological analysis of the biopsied specimens showed no evidence of adenoma or atypia. During follow-up, hyperparathyroidism persisted (PTH: 177<span class="elsevierStyleHsp" style=""></span>pg/mL, calcium 11.5<span class="elsevierStyleHsp" style=""></span>mg/dL), so a new scintigraphy was requested (12 months postoperatively, <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) and two cervical ultrasounds (13 and 24 months after the surgery) which were negative.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">In view of the biochemical persistence of the disease and negativity of conventional tests, a PET/CT with <span class="elsevierStyleSup">18</span>F-Fluorocholine was performed (32 months post-intervention, <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>), which showed a focal uptake (SUVmax: 7), posterior to the left inferior thyroid pole. After surgical exeresis, hyperplasia without atypia was confirmed. The analytical values at 15 days after reintervention were normal (calcium 9.5<span class="elsevierStyleHsp" style=""></span>mg/dL, parathyroid hormone: 29.3<span class="elsevierStyleHsp" style=""></span>pg/mL).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">HPP is a common endocrine disorder, characterized by an increase in PTH secretion by the parathyroid glands and leading to hypercalcemia.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> Up to 84% of cases are caused by an adenoma; less frequently, a hyperplasia, a multiglandular disease and, exceptionally, a carcinoma.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> The preoperative identification of the lesion reduces complications and comorbidity.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Conventional localization techniques include ultrasound and <span class="elsevierStyleSup">99m</span>Tc-MIBI scintigraphy with a sensitivity of 63.2% and 80.3%, respectively.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1,3</span></a> In cases where these techniques are negative, PET/CT with <span class="elsevierStyleSup">18</span>F-Fluorocholine is a good alternative, with a sensitivity of 91–92%,<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1–3</span></a> if 11C-Methionine is not available (sensitivity 92%).<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> In our case, the PET/CT allowed the correct localization and excision of the lesion.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, PET/CT with <span class="elsevierStyleSup">18</span>F-Fluorocholine is a tool to be considered for the localization of hyperfunctioning parathyroid tissue in selected cases (hyperplasia, ectopic glands, cervical surgical history and negativity in conventional techniques).</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Villasboas-Rosciolesi D, García-Burillo A, González-López O, Caubet-Busquet E, Castell-Conesa J. Detección de tejido paratiroideo hiperfuncionante mediante PET/CT con <span class="elsevierStyleSup">18</span>F-Fluorocolina. Rev Esp Med Nucl Imagen Mol. 2019;38:118–120.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 783 "Ancho" => 1400 "Tamanyo" => 102399 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">39-Year-old man with clinical suspicion of primary hyperparathyroidism (calcium 11.9<span class="elsevierStyleHsp" style=""></span>mg/dL, phosphate: 3.1<span class="elsevierStyleHsp" style=""></span>mg/dL, calcidiol 21.8<span class="elsevierStyleHsp" style=""></span>ng/mL and PTH 144<span class="elsevierStyleHsp" style=""></span>pg/mL), whose ultrasound study showed a hypoechoic image of 8<span class="elsevierStyleHsp" style=""></span>mm behind the right inferior thyroid pole, without internal vascularization (colour Doppler) suggestive of parathyroid gland versus lymph node image. (A) Anterior planar projection after 15<span class="elsevierStyleHsp" style=""></span>min of intravenous administration of 222<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-Pertechnetate. (B) Anterior planar images after 15 min (B1) and 120 min (B2)<span class="elsevierStyleHsp" style=""></span>of intravenous administration of 666<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">99m</span>Tc-sestaMIBI. (C) Coronal and axial SPECT/CT images 60<span class="elsevierStyleHsp" style=""></span>min after the administration of the radiopharmaceutical. The study does not show the presence of hyperfunctioning parathyroid tissue. The patient underwent surgery, where the parathyroid glands presented a normal appearance, biopsy samples were taken from both right parathyroids; the histopathological analysis showed no evidence of the presence of adenoma or cellular atypia. The ultrasound image corresponded to a lymph node.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 680 "Ancho" => 1400 "Tamanyo" => 76714 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Further imaging studies in the patient with persistent biochemical hyperparathyroidism (PTH: 177<span class="elsevierStyleHsp" style=""></span>pg/mL, calcium 11.5<span class="elsevierStyleHsp" style=""></span>mg/dL), 12 months after surgery were performed. Thyroid (A) and parathyroid (B1 and B2) scintigraphy were performed, same protocol as in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>. A study was completed with acquisition of SPECT/CT (C), in which, as in planar images, no parathyroid hyperfunction was evident. Likewise, two cervical ultrasounds were performed (at 13 and 24 months after surgery) that did not show significant lesions.</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">In view of the persistence of the biochemical alteration and the negativity of the conventional morpho-functional studies, it was decided to perform a PET/CT study with <span class="elsevierStyleSup">18</span>F-Fluorocholine (32 months after the surgery, <a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1260 "Ancho" => 1400 "Tamanyo" => 137512 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A PET/CT study with intravenous contrast at 60<span class="elsevierStyleHsp" style=""></span>min after intravenous administration of 370<span class="elsevierStyleHsp" style=""></span>MBq of <span class="elsevierStyleSup">18</span>F-Fluorocholine, in a patient with biochemical persistence of hyperparathyroidism after biopsy of both right parathyroid glands, was performed. (A) Coronal PET image in which a focal paramedial increase uptake (arrow) is observed; in the axial section (PET: B, CT: C and fusion: D) an increase in phospholipid metabolism can be localized in the left prevertebral region (solid black arrow in B, SUVmax: 7), this finding corresponds to a solid lesion that showed enhancement iodinated contrast (solid white arrow in C) in a left pre-vertebral and paraesophageal location. After surgery, the histopathological report revealed the existence of parathyroid hyperplasia, and the serum levels of calcium and parathyroid hormone normalized (9.5<span class="elsevierStyleHsp" style=""></span>mg/dL and 29.3<span class="elsevierStyleHsp" style=""></span>pg/mL, respectively).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enabling minimal invasive parathyroidectomy for patients with primary hyperparathyroidism using Tc-99m-sestamibi SPECT–CT, ultrasound and first results of <span class="elsevierStyleSup">18</span>F-fluorocholine PET–CT" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.P. Kluijfhout" 1 => "W.M. Vorselaars" 2 => "M.R. Vriens" 3 => "I.H. Borel Rinkes" 4 => "G.D. Valk" 5 => "B. de Keizer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejrad.2015.05.024" "Revista" => array:6 [ "tituloSerie" => "Eur J Radiol" "fecha" => "2015" "volumen" => "84" "paginaInicial" => "1745" "paginaFinal" => "1751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26047823" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleSup">18</span>F-Fluorocholine PET/CT for localization of hyperfunctioning parathyroid tissue in primary hyperparathyroidism: a pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Lezaic" 1 => "S. Rep" 2 => "M.J. Sever" 3 => "T. Kocjan" 4 => "M. Hocevar" 5 => "J. Fettich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00259-014-2837-0" "Revista" => array:6 [ "tituloSerie" => "Eur J Nucl Med Mol Imaging" "fecha" => "2014" "volumen" => "41" "paginaInicial" => "2083" "paginaFinal" => "2089" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25063039" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pilot comparison of <span class="elsevierStyleSup">18</span>F-fluorocholine PET/CT. Ultrasonography and <span class="elsevierStyleSup">123</span>I/<span class="elsevierStyleSup">99m</span>Tc-sestaMIBI dual-phase dual-isotope scintigraphy in the preoperative localization of hyperfunctioning parathyroid glands in primary or secondary hyperparathyroidism" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Michaud" 1 => "S. Balogova" 2 => "A. Burgess" 3 => "J. Ohnona" 4 => "V. Huchet" 5 => "K. Kerrou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MD.0000000000001701" "Revista" => array:5 [ "tituloSerie" => "Medicine" "fecha" => "2015" "volumen" => "94" "paginaInicial" => "e1701" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26469908" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/22538089/0000003800000002/v1_201903020621/S2253808918300107/v1_201903020621/en/main.assets" "Apartado" => array:4 [ "identificador" => "7927" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Interesting images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/22538089/0000003800000002/v1_201903020621/S2253808918300107/v1_201903020621/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918300107?idApp=UINPBA00004N" ]
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The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles. The works may be submitted in Spanish or English and are subjected to a peer review process. In 2009, it became the leading Spanish journal in the field of Medical Imaging on having an Impact Factor , awarded by the Journal Citation Reports.
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See moreThe Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.
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