metricas
covid
Buscar en
Clinics
Toda la web
Inicio Clinics Recurrent Post-Traumatic Non-Eosinophilic Pleural Effusion: Report of Three Case...
Información de la revista
Vol. 63. Núm. 3.
Páginas 414-415 (junio 2008)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Visitas
895
Vol. 63. Núm. 3.
Páginas 414-415 (junio 2008)
Letter to the Editor
Open Access
Recurrent Post-Traumatic Non-Eosinophilic Pleural Effusion: Report of Three Cases
Visitas
895
Artur Eugênio de Azevedo PereiraI, Ricardo Mingarini TerraI, Lisete Ribeiro TeixeiraII, Paulo Manuel Pêgo-FernandesI, Fábio Biscegli JateneI
I Department of General Thoracic Surgery, Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil
II Pulmonary Division, Faculdade de Medicina da Universidade de São Paulo - São Paulo/SP, Brazil
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Texto completo
INTRODUCTION

Post-traumatic pleural effusion is an uncommon clinical entity, though it may occur after chest wall trauma, thoracentesis, or thoracotomy. Its most prominent feature is a high eosinophil count at pleural fluid cytology.1 There are no previous reports of non-eosinophilic post-traumatic pleural effusion.

CASE DESCRIPTIONCase 1

A 25-year-old woman had a car accident with chest wall trauma and was evaluated elsewhere. Chest x-ray showed rib fractures, but no pleural effusion, and the woman was subsequently discharged. After one month, she complained of dyspnea and chest pain and underwent thoracentesis elsewhere. Fifteen days later, she was admitted to our hospital on account of symptom recurrence. As a result of another thoracentesis, 1,800 ml of fluid were drained (Table-1). As the patient reported no further complaints, she did not undergo pleural biopsy.

Table 1.

Clinical data and pleural fluid analysis

  Case-1  Case-2  Case-3 
Gender  Female  Male  Female 
Age (years)  25  60  36 
Trauma  Car accident  Car accident  Costectomy 
Fractures  Ribs  Sternum and Ribs  Ribs 
LDH(mg/dl)  257  341  315 
Protein(g/dl)  4,9  5,5  5,1 
ADA(U/l)  8,8  13  28,1 
Cytology  N29% L68% E01%  N03% L88% E03%  N16% L75% E02% 
Procedure  Thoracentesis  Videothoracoscopy  Videothoracoscopy 

LDH:lactic dehydrogenase; ADA:adenosine deaminase; N:Neutrophils; L:Lymphocytes; E:Eosinophils.

Case 2

A 60-year-old man had a car accident and experienced chest wall trauma. He was evaluated elsewhere, and chest x-ray showed sternal and bilateral rib fractures without pleural effusion. The man was then discharged. After one month, he complained of worsening left chest pain, and a chest x-ray demonstrated left pleural effusion. As a result of thoracentesis, 1,000ml of fluid were drained (Table-1). Pleural effusion recurred and he underwent a diagnostic videothoracoscopy with pleural biopsy that demonstrated reactive pleuritis with negative cultures. There were no recurrences.

Case 3

A 36-year-old woman underwent a surgical procedure for thoracic scoliosis correction with partial costectomy of five ribs. After a five-week uneventful post-operative period, she had pleuritic chest pain. A chest x-ray showed pleural effusion, and thoracentesis revealed a lymphocytic exudate (Table-1). Pleural effusion recurred, and she underwent a diagnostic videothoracoscopy with pleural biopsy that demonstrated chronic pleuritis. There was no recurrence.

DISCUSSION

The etiology of post-traumatic eosinophilic pleural effusion is attributed to immune complex reaction, probably related to the presence of air or blood in the pleural space.2–6 To the authors′ knowledge, there are no reports of lymphocytic pleural effusion associated with post-traumatic conditions.

The patients had extensive chest wall trauma and rib fractures. However, no sign of pleural space violation was detected during the early post-trauma period, which could explain the absence of eosinophils upon post-traumatic pleural effusion analysis.2 The patients developed symptoms one month after the trauma and had a recurrent lymphocitic exudative pleural effusion.

Although there is a high incidence of small pleural effusion immediately after cardiac surgery,7 a series of lymphocitic pleural effusions with low LDH occurring more than 1 month after coronary artery bypass grafting (CABG) has been described.8 This type of pleural effusion could be related to the local trauma involved with CABG, which could lead to a local immunological reaction, interruption of pleural lymphatics, or leakage of fluid from the mediastinum. Our patients had extensive subpleural trauma and hematoma due to rib fractures, and possibly a mediastinal hematoma in case 2, similar to that observed in CABG. Indeed, pleural fluid analysis demonstrated similar LDH and cell count results. Consequently, we believe the mechanism might be the same.

Post-traumatic lymphocitic pleural effusion is a rare clinical entity that is probably related to subpleural trauma or dissection, and may recur and be treated with pleural drainage.

REFERENCES
[1]
I Falcón Panella , L Force Sanmartín , JA Hernandéz .
Derrame pleural eosinófilo post-traumático.
An Med Interna (Madrid), 21 (2004), pp. 61-62
[2]
J Heidecker , A Kaplan , SA Sahn .
Pleural fluid and peripheral eosinophilia from hemothorax: Hypothesis of the pathogenesis of EPE in hemothorax and pneumothorax.
Am J Med Sci, 332 (2006), pp. 148-152
[3]
F de Blay , A Aykut-Baturalp , J Goetz , A Purohit , A Perez-Infante , G Hauptmann , et al.
Post-traumatic pleural effusion: demonstration of local complement consumption.
Respir Med, 91 (1997), pp. 373-375
[4]
I Kalomenidis , Y Guo , S Peebles , KB Lane , S Papiris , J Elias , et al.
Pneumothorax-associated pleural eosinophilia in mice is interleukin-5 but not interleukin-13 dependent.
Chest, 128 (2005), pp. 2978-2983
[5]
Y Ishiura , M Fujimura , N Nakamura , H Jokaji , S Minami , T Matsuda .
Intrapleural corticosteroid injection therapy for post-traumatic eosinophilic pleural effusion.
Respir Med, 90 (1996), pp. 501-503
[6]
JB Rubins , HB Rubins .
Etiology and prognostic significance of eosinophilic pleural effusions.
Chest, 110 (1996), pp. 1271-1274
[7]
FS Vargas , A Cukier , W Hueb , LR Teixeira , RW Light .
Relationship between pleural effusion and pericardial involvement after myocardial revascularization.
Chest, 105 (1994), pp. 1748-1752
[8]
RW Light , JT Rogers , D Cheng , M Rodriguez .
Large pleural effusions occurring after coronary artery bypass grafting.
Copyright © 2008. CLINICS
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos