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Número
Vol. 77.
(enero - diciembre 2022)
Editorials
COVID-19 pandemic repercussions on undergraduate teaching in obstetrics and gynecology
Lívia Sousa Ribeiro, Rossana Pulcineli Vieira Francisco, Fábio Roberto Cabar
Clinics. 2022;77C:100025
Acceso a texto completo
A new era for the international representativeness of CLINICS Journal
Luiz Felipe P. Moreira, José Maria Soares Jr.
Clinics. 2022;77C:100030
Acceso a texto completo
The right to vaccination and the individual duty in collective health during a pandemic
Juliana Bertoldi Franco, Pilar Lecussan Gutierrez, Fábio Roberto Cabar, Chin An Lin
Clinics. 2022;77C:100035
Acceso a texto completo
SARS-CoV-2 vaccines: Potential refinements through induction of mucosal and trained immunity
Amanda Izeli Portilho, Gabrielle Gimenes Lima, Elizabeth De Gaspari
Clinics. 2022;77C:100057
Acceso a texto completo
Sex differences in Parkinson's Disease: An emerging health question
Luiz Philipe de Souza Ferreira, Rafael André da Silva, Matheus Marques Mesquita da Costa, Vinicius Moraes de Paiva Roda, Santiago Vizcaino, Nilma R.L.L. Janisset, Renata Ramos Vieira, José Marcos Sanches, ... Manuel de Jesus Simões
Clinics. 2022;77C:100121
Acceso a texto completo
Original articles
Long non-coding RNA DLGAP1 antisense RNA 1 accelerates glioma progression via the microRNA-628-5p/DEAD-box helicase 59 pathway
Ke-qi Hu, Xiang-sheng Ao
Clinics. 2022;77C:100002
Highlights

  • The expression of DLGAP1-AS1 expression is increased in glioma.

  • DLGAP1-AS1 promotes the malignancy of glioma via modulating miR-628-5p/DDX59 axis.

Acceso a texto completo
Cardiopulmonary exercise test in patients with refractory angina: functional and ischemic evaluation
Camila R.A. de Assumpção, Danilo M.L. do Prado, Camila P. Jordão, Luciana O.C. Dourado, Marcelo L.C. Vieira, Carla G. de S.P. Montenegro, Carlos E. Negrão, Luís H.W. Gowdak, Luciana D.N.J. De Matos
Clinics. 2022;77C:100003
Highlights

  • OUES analysis is useful for assessing functional capacity in refractory angina.

  • O2 pulse curve is correlated with contractile alterations in exercise echocardiogram.

  • Cardiopulmonary exercise test is useful toll in patients with refractory angina.

Acceso a texto completo
Readmission of late preterm and term neonates in the neonatal period
Darjan Kardum, Ivana Serdarušić, Borna Biljan, Krešimir Šantić, Vinko Živković
Clinics. 2022;77C:100005
Highlights

  • In infants gestational age ≥ 36 weeks the readmission rate is 4.0%.

  • Most common causes are respiratory infections, jaundice, and feeding problems.

  • Initial care in special care or NICU setting showed reduced readmission rates.

Acceso a texto completo
Effects of ganglioside GM1 and erythropoietin on spinal cord injury in mice: Functional and immunohistochemical assessments
Alessandro Gonzalez Torelli, Alexandre Fogaça Cristante, Tarcísio Eloy Pessoa de Barros-Filho, Gustavo Bispo dos Santos, Beatriz Cintra Morena, Felipe Fernandes Correia, Vera Paschon
Clinics. 2022;77C:100006
Highlights

  • GM1 and erythropoietin bring neurological improvement in mice with blunt spinal cord injury.

Acceso a texto completo
Influence of invertor and evertor muscle fatigue on functional jump tests and postural control: A prospective cross-sectional study
Gabriela Borin Castillo, Guilherme Carlos Brech, Nátalia Mariana Silva Luna, Fernanda Botta Tarallo, Jose Maria Soares-Junior, Edmund Chada Baracat, Angelica Castilho Alonso, Júlia Maria D'Andréa Greve
Clinics. 2022;77C:100011
Highlights

  • Fatigue of the ankle's stabilizing muscles does influence the performance.

  • Functional jump tests are low cost and useful for clinical practice.

  • Functional jump tests can evaluate of the effects of muscle fatigue.

Acceso a texto completo
Increasing rate of anti-SARS-CoV-2 antibodies between the first and second waves of COVID-19 in São Paulo, Brazil: A cross-sectional blood donors-based study
Nayara Moya Rios do Vale, Flavia Roche Moreira Latini, Carine Prisco Arnoni, Rafael Martins Parreira, Manoel João Batista Castelo Girão, Afonso José Pereira Cortez, Tatiana Carvalho de Souza Bonetti
Clinics. 2022;77C:100016
Highlights

  • Anti-SARS-CoV-2 antibodies in blood donors in the state of São Paulo.

  • High prevalence of anti-SARS-CoV-2 antibodies in donors using public transport.

Acceso a texto completo
Risk of osteoporotic fracture in women using the FRAX tool with and without bone mineral density score in patients followed at a tertiary outpatient clinic ‒ An observational study
Maria Helena Sampaio Favarato, Maria Flora de Almeida, Arnaldo Lichtenstein, Milton de Arruda Martins, Mario Ferreira Junior
Clinics. 2022;77C:100015
Highlights

  • FRAX without BD moderately to strongly correlates to FRAX with BD and tends to superestime 10-year fracture risk prediction.

  • FRAX without BD is reliable and sensitive as a screening tool even in multimorbid patients.

Acceso a texto completo
Clinical value of preferred endoscopic ultrasound-guided antegrade surgery in the treatment of extrahepatic bile duct malignant obstruction
Xuan Zhao, Lihong Shi, Jinchen Wang, Siming Guo, Sumin Zhu
Clinics. 2022;77C:100017
Highlights

  • The aim of the research is to explore the clinical value of preferred ultrasound endoscopic guided biliary drainage in patients with extrahepatic biliary obstruction with intrahepatic biliary ectasis.

  • A prospective randomized controlled study was randomized into EUS-AG and ERCP-BD, with 28 patients in EUS-AG and 30 in ERCP-BD.

  • The authors found the EUS-AG operation can be done in a short time, low incidence of complications, is safe, effective, and can be used as the preferred treatment plan for patients with extrahepatic biliary duct malignant obstruction.

Acceso a texto completo
Lacticaseibacillus rhamnosus modulates the inflammatory response and the subsequent lung damage in a murine model of acute lung inflammation
Fabiana Olimpio, José Roberto Mateus da Silva, Rodolfo P. Vieira, Carlos R. Oliveira, Flavio Aimbire
Clinics. 2022;77C:100021
Highlights

  • Lacticaseibacillus rhamnosus prevents lung neutrophilia.

  • Lacticaseibacillus rhamnosus attenuates bronchial hyperreactivity.

  • Lacticaseibacillus rhamnosus reduces pulmonary oedema.

Acceso a texto completo
Incidental thyroid carcinoma: Correlation between FNAB cytology and pathological examination in 1093 cases
Mariana Gonçalves Rodrigues, Luiz Fernando Ferraz da Silva, Vergilius José Furtado de Araujo-Filho, Letícia de Moraes Mosca, Vergilius José Furtado de Araujo-Neto, Luiz Paulo Kowalski, Paulo Campos Carneiro
Clinics. 2022;77C:100022
Highlights

  • Incidental thyroid carcinomas are diagnosed by pathological study of the surgical specimen, with no previous suspicion by other diagnostic methods before surgery.

  • Incidental thyroid cancer has been found at high rates in men and young people, usually, but not always, with more favorable histopathological characteristics and better prognosis.

  • The better understanding of incidental thyroid cancer can improve decisions towards active surveillance strategies for the management of papillary thyroid carcinoma.

Acceso a texto completo
MicroRNA-128b mediates lipopolysaccharide-induced apoptosis via reactive oxygen species in human pulmonary microvascular endothelial cells
Guangwen Long, Xiulin Yang, Chunling Ji, Yukang Dong
Clinics. 2022;77C:100020
Highlights

  • We observed that miR-128b regulated LPS-induced apoptosis of HPMECs and identified its mechanism.

  • LPS induced apoptosis and ROS production and upregulated miR-128b and caspase-3 expressions in HPMECs.

  • miR-128b has a potential therapeutic target for the treatment of ARDS.

Acceso a texto completo
Clinical features of hereditary angioedema and warning signs (H4AE) for its identification
Pedro Giavina-Bianchi, Marcelo Vivolo Aun, Juliana Fóes Bianchini Garcia, Laís Souza Gomes, Ana Júlia Ribeiro, Priscila Takejima, Rosana Câmara Agondi, Jorge Kalil, Antonio Abilio Motta
Clinics. 2022;77C:100023
Highlights

  • ""H4AE"": warning signs for hereditary angioedema identification.

  • Hereditary angioedema is unknown and underdiagnosed.

  • Hereditary angioedema has high morbidity and may be fatal.

Acceso a texto completo
microRNA-181a-5p impedes the proliferation, migration, and invasion of retinoblastoma cells by targeting the NRAS proto-oncogene
Ming Ouyang, Guiqin Liu, Cheng Xiong, Jing Rao
Clinics. 2022;77C:100026
Highlights

  • miR-181a-5p expression was found to be decreased in retinoblastoma tissues and cell lines.

  • miR-181a-5p reduced retinoblastoma cell proliferation, migration, and invasion while enhancing apoptosis.

  • NRAS is a direct target of miR-181a-5p.

Acceso a texto completo
Magnetic resonance imaging and previous cesarean section in placenta accrete spectrum disorder: Predictor model
Rodrigo Pamplona Polizio, Fernando Ide Yamauchi, Renata Franco Pimentel Mendes, Stela Verzinhasse Peres, Mario Macoto Kondo, Rossana Pulcineli Vieira Francisco
Clinics. 2022;77C:100027
Highlights

  • Predicting placenta accreta spectrum disorder with magnetic resonance imaging.

  • Estimating probability of placenta accreta spectrum disorder.

Acceso a texto completo
Circ_0075825 promotes gastric cancer progression via adsorbing miR-432-5p to modulate SOX9
He Li, Xiaohua Zhou, Zhuangming Yu, Youjing Tian
Clinics. 2022;77C:100018
Highlights

  • Circ_0075825 is highly expressed in gastric cancer tissues.

  • Circ_0075825 promotes the malignant biological behaviors of gastric cancer cells.

  • Circ_0075825 functions as a molecular sponge to repress miR-432-5p and up-regulate SOX9.

Acceso a texto completo
Plasma lathosterol measures rates of cholesterol synthesis and efficiency of dietary phytosterols in reducing the plasma cholesterol concentration
Valéria Sutti Nunes, Angela de Oliveira Godoy Ilha, Guilherme da Silva Ferreira, Renata de Paula Assis Bombo, Milessa Silva Afonso, Maria Silvia Ferrari Lavrador, Roberta Marcondes Machado, Edna Regina Nakandakare, ... Ana Maria Lottenberg
Clinics. 2022;77C:100028
Highlights

  • Phytosterols supplementation reduced total cholesterol, LDL-C, apo B, and triglycerides.

  • Phytosterols supplementation increased plasma lathosterol as well as campesterol and sitosterol, indicating compliance to the diets.

  • Lathosterol-to-cholesterol ratio predicted the cholesterol response to phytosterols feeding.

  • High basal cholesterol synthesis is associated with a lack of response to plasma cholesterol.

Acceso a texto completo
IRF4 suppresses osteogenic differentiation of BM-MSCs by transcriptionally activating miR-636/DOCK9 axis
Xuepu Zhang, Yue Zhang, Limin Yang, Yuexin Wu, Xiaohu Ma, Gang Tong, Zhaoliang Ban, Haosen Zhao
Clinics. 2022;77C:100019
Highlights

  • IRF4 is a negative regulator during the osteogenic differentiation of BM-MSCs.

  • IRF4 can transcriptionally activate microRNA-636 in BM-MSCs.

  • MicroRNA-636 can suppress the osteogenic differentiationof BM-MSCs by directly targeting DOCK9.

Acceso a texto completo
Chronic inflammatory diseases, subclinical atherosclerosis, and cardiovascular diseases: Design, objectives, and baseline characteristics of a prospective case-cohort study ‒ ELSA-Brasil
Isabela M. Bensenor, Alessandra C. Goulart, Alexandre C. Pereira, André R. Brunoni, Airlane Alencar, Raul D. Santos, Márcio S. Bittencourt, Rosa W. Telles, ... Paulo A. Lotufo
Clinics. 2022;77C:100013
Highlights

  • The morbidity and mortality associated with cardiovascular diseases may be higher in patients with chronic inflammatory diseases.

  • The lipid paradox has to be studied in all chronic inflammatory diseases.

  • The performance of scores of cardiovascular risk may underestimate the real risk in patients with chronic inflammatory diseases.

Acceso a texto completo
Gathering patients and rheumatologists' perceptions to improve outcomes in idiopathic inflammatory myopathies
Isabela M. Bertoglio, Glaucia F. Abrahao, Fernando H.C. de Souza, Renata Miossi, Paloma C. de Moraes, Samuel K. Shinjo, Eloisa Bonfá, Michelle R. Ugolini Lopes
Clinics. 2022;77C:100031
HIGHLIGHTS

  • Development of a novel standard set to be pursued in IIM follow-up, including main outcome concerns of patients and rheumatologists.

  • Additional important outcomes only indicated by patients such as controlling pain, fatigue and skin lesions were also included in this standard set.

  • The proposed IIM standard set evaluation consists of MOYACT, MMT8, fatigue and pain VAS, HAQ, and level of physical activity.

Acceso a texto completo
Methyl-CpG binding protein 2 is associated with the prognosis and mortality of elderly patients with hip fractures
Xuejian Gao, Shan Xue, Fuqiang Yang, Baoling Wu, Xiaojing Yu, Baoquan An
Clinics. 2022;77C:100034
Highlights

  • MECP2 was downregulated in elderly patients with hip fracture.

  • MECP2 was correlated with inflammatory factors in hip fractures.

  • Lower MECP2 predicted poor clinical outcomes of hip fractures.

  • Lower MECP2 predicted higher mortality and postoperative complications.

Acceso a texto completo
Neuropathologic damage induced by radiofrequency ablation at different temperatures
Yu Dong, Ying Chen, Baoguo Yao, Peng Song, Ruiting Xu, Rui Li, Ping Liu, Yu Zhang, ... Li Su
Clinics. 2022;77C:100033
Highlights

  • There is a positive correlation between temperature and neuropathological damage caused by RFA at different temperatures.

  • There is a positive correlation between nerve conduction velocity and temperature.

  • Nerve injury occurs when the temperature reaches 67°C, and the main pathogenesis is closely related to the expression of SCN9A, SCN3B and NFASC protein in sciatic nerve tissue caused by heat transfer injury.

Acceso a texto completo
L1 cell adhesion molecule high expression is associated with poor prognosis in surgically resected brain metastases from lung adenocarcinoma
Jia-Wei Wang, Song-Quan Wang, Zhuo-Yi Wu, Qi Liu, Qing Yuan, Hong-Qing Cai, Jing-Hai Wan
Clinics. 2022;77C:100040
Highlights

  • Brain metastasis aberrantly expresses L1CAM.

  • L1CAM high expression is associated with poor prognosis in brain metastases.

Acceso a texto completo
Team emergency assessment measure (TEAM) of non-technical skills: The Brazilian Portuguese version of the TEAM tool
Fernando Rabioglio Giugni, Roger Daglius Dias, Caio Godoy Rodrigues, Henrique Trombini Pinesi, Augusto Scalabrini-Neto
Clinics. 2022;77C:100043
Highlights

  • The authors translated and cross-culturally adapted the TEAM tool into Brazilian Portuguese.

  • The Brazilian Portuguese TEAM version proved to be a consistent and reliable tool.

Acceso a texto completo
Changes in postural balance associated with a woman's aging process
Guilherme Carlos Brech, Tatiana Godoy Bobbio, Kelem de Negreiros Cabral, Patrícia Mota Coutinho, Leila Regina de Castro, Luis Mochizuki, Jose Maria Soares-Junior, Edmund Chada Baracat, ... Angélica Castilho Alonso
Clinics. 2022;77C:100041
Highlights

  • Aging process increases postural oscillations, worsening the postural balance.

  • Poor postural balance is more evident in the elderly over 80-years old.

  • Deterioration of the postural control systems and the increased risk of falls.

  • Important identify factors related to falls and postural balance.

Acceso a texto completo
CLEC14A was up-regulated in hepatocellular carcinoma and may function as a potential diagnostic biomarker
Lang Yan, Xiang Li, Yunfeng Yuan
Clinics. 2022;77C:100029
Highlights

  • Over-expression of CLEC14A was in HCC.

  • CLEC14A may function as a potential diagnostic biomarker for HCC.

  • Over-expression of CLEC14A was in HCC cells.

  • Knockdown of CLEC14A decreased the viability and increased the apoptosis of HuH-7 cell.

Acceso a texto completo
Invariant Natural Killer T-cells and their subtypes may play a role in the pathogenesis of endometriosis
Frederico J.S. Correa, Marina Paula Andres, Tainá Pezzin Rocha, Ana Eduarda Z. Carvalho, Thiago P.A. Aloia, Marcus V.N. Corpa, Esper G. Kallas, Cristóvão L.P. Mangueira, ... Mauricio S. Abrão
Clinics. 2022;77C:100032
Highlights

  • The frequency of iNKT cells in general and their subtype double-negative are related to endometriosis.

  • The expression of IL-17 and CCR7 by iNKT cells are related to endometriosis-associated pain symptoms.

  • iNKT cells are numerically and functionally altered in women with endometriosis.

Acceso a texto completo
IPO7 promotes pancreatic cancer progression via regulating ERBB pathway
Ming Li, Dongqiang Xu, Yijun Zhan, Shiyun Tan
Clinics. 2022;77C:100044
Highlights

  • IPO7 remarkably enhanced pancreatic cancer cell proliferation, migration and invasion and suppressed apoptosis.

  • IPO7 facilitated the malignant phenotype of pancreatic cancer cells by up-regulating ERBB2.

  • Knockdown of IPO7 inhibited tumor growth and lung metastasis in vivo.

Acceso a texto completo
Role of apolipoprotein O in autophagy via the p38 mitogen-activated protein kinase signaling pathway in myocardial infarction
Yue Liu, Zhiping Xiong, Wei Zhou, Yuxin Chen, Qing Huang, Yanqing Wu
Clinics. 2022;77C:100046
Highlights

  • • APOO was highly expressed in the left ventricle of mice with myocardial infarction.

  • • Increasing of APOO may activate autophagy and apoptosis in myocardial infarction.

  • • The regulation of APOO in autophagy and apoptosis was regulated by p38MAPK signaling pathway.

Acceso a texto completo
Adherence to the cardiac surgery checklist decreased mortality at a teaching hospital: A retrospective cohort study
Omar Asdrúbal Vilca Mejia, Frederico Carlos Cordeiro de Mendonça, Lucimar Aparecida Barrense Nogueira Sampaio, Filomena Regina Barbosa Gomes Galas, Mauricio Franklin Pontes, Luiz Fernando Caneo, Luís Roberto Palma Dallan, Luiz Augusto Ferreira Lisboa, ... Fabio Biscegli Jatene
Clinics. 2022;77C:100048
Highlights

  • • Checklists avoid human errors and are commonly used in high-reliability industries.

  • • The “InCor Checklist” was associated with decreased mortality over time.

  • • Adherence, completeness, and sustainability within public policies are necessary.

Acceso a texto completo
let-7b-5p suppresses the proliferation and migration of pulmonary artery smooth muscle cells via down-regulating IGF1
Yadi Zhang, Sihui Tang, Wanchun Yang, Fangbing Du
Clinics. 2022;77C:100051
Acceso a texto completo
Novel rearrangements between different chromosomes with direct impact on the diagnosis of 5p- syndrome
Samar Nasser Chehimi, Vanessa Tavares Almeida, Amom Mendes Nascimento, Évelin Aline Zanardo, Yanca Gasparini de Oliveira, Gleyson Francisco da Silva Carvalho, Beatriz Martins Wolff, Marilia Moreira Montenegro, ... Leslie Domenici Kulikowski
Clinics. 2022;77C:100045
Highlights

  • The authors The authors have described three novel rearrangements between chromosomes 5 and 2, 5 and 18, and 5 and Y with chromosomal breakpoints and overlapped phenotypes that were not previously described.

  • One of the main atypical features for 5p- syndrome that the authors report was the presence of seizures that was found in the three patients with rearrangements between different chromosomes and in a patient with a deletion followed by duplication in 5p.

  • The authors suggest physicians conduct further molecular investigation in the presence of atypical clinical features for patients with 5p- syndrome suspicion.

Acceso a texto completo
LncRNA LINC01857 drives pancreatic adenocarcinoma progression via modulating miR-19a-3p/SMOC2
Yeting Lu, Dongjian Ying, Yuan Tian, Yi Ruan, Gong Cheng, Kaiji Lv, Xinhua Zhou, Shuo Han
Clinics. 2022;77C:100047
Highlights

  • LINC01857 is upregulated in PAAD and promotes malignant cellular behaviors.

  • LINC01857 interacts with miR-19a-3p to regulate SMOC2 expression.

  • LINC01857 promotes malignant cellular phenotypes by upregulating SMOC2.

Acceso a texto completo
SNHG22 promotes migration and invasion of trophoblasts via miR-128-3p/PCDH11X axis and activates PI3K/Akt signaling pathway
Xiaoying Wei, Yichong Yuan, Qiong Yang
Clinics. 2022;77C:100055
Highlights

  • SNHG22 in downregulated in placentas from PE patients.

  • Overexpression of SNHG22 promotes the migration and invasion of trophoblasts.

  • SNHG22 works as a sponger of microRNA-128-3p to increase PCDH11X expression in trophoblasts.

  • SNHG22 modulates PCDH11X-activated PI3K/Akt signaling to drive migration and invasion of trophoblasts.

Acceso a texto completo
Associations of systemic inflammatory markers with the risks of chronic heart failure: A case-control study
Zhaojun Liu, Yingjie Xv, Xiaozhu Liu, Xiaoli Zhou
Clinics. 2022;77C:100056
Highlights

  • Two novel inflammation-related markers, LMR and MHR are associated with Chronic Heart Failure (CHF).

  • LMR and MHR were first proposed to be the predictors of a diagnosis of CHF in this study, which suggested that inflammation was associated with CHF, and anti-inflammation therapy might be a potential target for future therapeutic interventions.

  • Compared with special inflammatory indicators such as TNF or IL-1, LMR and MHR are routinely measured in clinical practice and less time-consuming, which makes them suitable for popularization.

Acceso a texto completo
Frequency and factors associated with hospital readmission after COVID-19 hospitalization: the importance of post-COVID diarrhea
Maristela Pinheiro Freire, Maura Salaroli Oliveira, Marcello Mihailenko Chaves Magri, Bruno Melo Tavares, Igor Marinho, Ana Catharina De Seixas Santos Nastri, Geraldo Busatto Filho, Anna S. Levin
Clinics. 2022;77C:100061
Highlights

  • 32% of the patients visited an emergency room after COVID-19 hospitalization.

  • The rate of hospital readmission after COVID-19 hospitalization is high, in the present sample 10% of patients needed a second hospitalization in 6-months

  • Patients with persistent diarrhea after COVID-19 discharge had two times more chance to have another hospitalization in the next 6-months.

Acceso a texto completo
Quality of life in patients with malignant pleural effusion treated with an indwelling pleural catheter in an emerging country
Leticia Leone Lauricella, Paula Duarte D'Ambrosio, Priscila Berenice da Costa, Marcia Cristina Augusto, Paulo Manuel Pêgo-Fernandes, Ricardo Mingarini Terra
Clinics. 2022;77C:100063
Highlights

  • Indwelling pleural catheter represents a suitable option for patients with malignant pleural effusion and short life expectancy. It relieves respiratory symptoms without compromising the quality of life, and the complication rate is low, even in an emerging country, with a low socioeconomic and under-educated patient population. The rate of spontaneous pleurodesis was 45%. The analysis of the visual analog scale showed significant control of dyspnea (p = 0.001), but pain and quality of life did not change significantly.

Acceso a texto completo
miR-146b suppresses LPS-induced M1 macrophage polarization via inhibiting the FGL2-activated NF-κB/MAPK signaling pathway in inflammatory bowel disease
Yang Pan, Dan Wang, Fan Liu
Clinics. 2022;77C:100069
Highlights

  • miR-146b was downregulated in Inflammatory Bowel Disease (IBD) mice and LPS-induced macrophages.

  • Fibrinogen Like 2 (FGL2) was identified as the target gene of miR-146b.

  • miR-146b ameliorated the inflammation and blocked M1 macrophage polarization via inhibiting FGL2.

  • miR-146b ameliorated the symptoms and pathological injury of IBD via inhibiting FGL2.

Acceso a texto completo
Exosomal miR-152-5p and miR-3681-5p function as potential biomarkers for ST-segment elevation myocardial infarction
Xiaozhu Chen, Fengrong Huang, Yunhong Liu, Shujun Liu, Gangwen Tan
Clinics. 2022;77C:100038
Highlights

  • RT3D-STE and exosome miRNAs can be used as a hierarchical diagnostic system in AMI.

  • Exosomal miR-152-5p and miR-3681-5p function as potential biomarkers for ST-segment elevation myocardial infarction.

Acceso a texto completo
Decannulation: a retrospective cohort study of clinical and swallowing indicators of success
Carina Escudero, Fernanda Chiarion Sassi, Gisele Chagas de Medeiros, Maíra Santilli de Lima, Paulo Francisco Guerreiro Cardoso, Claudia Regina Furquim de Andrade
Clinics. 2022;77C:100071
Highlights

  • Deccanulation indicators were investigated in patients who were submitted to a tracheostomy procedure.

  • Early swallowing evaluation and rehabilitation were associated with a successful decannulation process.

  • Low swallowing functional levels were negatively associated with the success of decannulation.

Acceso a texto completo
Risk factors for oxygen requirement in hospitalized pregnant and postpartum women with COVID-19
Fernanda Spadotto Baptista, Cristiane Freitas Paganoti, Ursula Trovato Gomez, Stela Verzinhasse Peres, Luiz Marcelo Malbouisson, Maria de Lourdes Brizot, Rossana Pulcineli Vieira Francisco
Clinics. 2022;77C:100072
Highlights

  • In unvaccinated pregnant and postpartum women, any need for oxygen supply increases the risk of invasive ventilation.

  • Obesity, smoking and chronic arterial hypertension proved to be risk factors for the use of oxygen in pregnant and postpartum women with COVID-19.

  • The combination of C-reactive protein ≥ 21 mg/L, hemoglobin < 11.0 g/dL, and lymphopenia < 1500 mm3 on hospital admission and the presence of ground glass ≥ 50% in computer tomography increased the risk of O2 use by 4.97 and 5.33 times respectively in pregnant and postpartum women with COVID-19.

Acceso a texto completo
Absence of neutralizing antibodies against the Omicron SARS-CoV-2 variant in convalescent sera from individuals infected with the ancestral SARS-CoV-2 virus or its Gamma variant
Lucy Santos Villas-Boas, Anderson Vicente de Paula, Almir Ribeiro da Silva, Heuder Gustavo Oliveira Paiao, Tania Regina Tozetto-Mendoza, Erika Regina Manuli, Fábio Eudes Leal, Andrea de Barros Coscelli Ferraz, ... Maria Cassia Mendes-Correa
Clinics. 2022;77C:100068
Highlights

  • Individuals previously infected with SARS-CoV-2 ancestral strain do not develop neutralizing antibodies against the Omicron variant.

  • Omicron variant escapes immune response after SARS CoV-2 previous infection with the SARS CoV-2 Gamma variant.

  • Individuals previously infected with SARS-CoV-2 ancestral strain or with SARS-CoV-2 Gamma variant will likely have little protection if subsequently exposed to the Omicron variant.

Acceso a texto completo
The dual effect of acetate on microglial TNF-α production
Matheus Garcia Fragas, Daniel May de Oliveira, Meire Ioshie Hiyane, Tarcio Teodoro Braga, Niels Olsen Saraiva Camara
Clinics. 2022;77C:100062
Highlights

  • Acetate was able to exacerbate the production of TNF-α in microglia.

  • Acetate administered as pre-treatment to LPS acts as an anti-inflammatory.

  • Histone deacetylase decreased TNF-α production in Acetate- and LPS-treated cells.

  • Depending on the time of administration, Acetate modulates microglia's activation.

  • Acetate may threaten neurodegenerative and neuropsychiatric diseases.

Acceso a texto completo
Gene expression profile in experimental frozen-thawed ovarian grafts treated with scaffold-base delivery of adipose tissue-derived stem cells
Luciana Lamarão Damous, Marcos Eiji Shiroma, Ana Elisa Teófilo Saturi de Carvalho, José Maria Soares-Jr, José Eduardo Krieger, Edmund C. Baracat
Clinics. 2022;77C:100066
Highlights

  • The scaffold-based delivery therapy with adipose tissue-derived stem cells in the rat ovarian autografts seems to be the best option when compared to direct injection or systemic route.

  • Ovarian grafts treated with adipose tissue-derived stem cells showed the highest number of genes over-regulated in the apoptosis pathway, compared to inflammation cytokines and angiogenesis pathway.

  • Capsase14 was the most over-regulated gene in the apoptosis pathway.

  • The treatment with adipose tissue-derived stem cells in ovarian grafts treated didn't compromise the ovary graft morphology and viability for short time.

Acceso a texto completo
The lack of knowledge on acute stroke in Brazil: A cross-sectional study with children, adolescents, and adults from public schools
Marcelo Calderaro, Igor C. Salles, Gabriela B. Gouvêa, Vinícius S. Monteiro, Antonio P. Mansur, Henrique N.I. Shinohara, Priscila Aikawa, Iracema I.K. Umeda, ... Naomi K. Nakagawa
Clinics. 2022;77C:100052
Highlights

  • Higher education, prior experience, and being women improved the odds of identifying stroke warning signs and symptoms as associated risk factors

  • Improving knowledge, skills, and attitude on acute stroke in the school community may represent a significant advance in public health management

  • Future stroke awareness campaigns and educational efforts should focus on schoolchildren and adolescents, especially in low-income countries

Acceso a texto completo
Rat thyroid graft transplantation after cryopreservation with scintigraphic standardization for an experimental study
Alberto Schanaider, Thiago Barboza, Marcel Vasconcellos, Gabriel Gutfilen-Schlesinger, Sergio Augusto Lopes de Souza
Clinics. 2022;77C:100065
Highlights

  • Adaptations in validated methods are a recurrent trend due to limited budgets which does not diminish their functionality.

  • Scintigraphy with 99mTcO4 is effective in evaluating the functionality of thyroid grafts after cryopreservation in rats.

  • It is possible to adapt human SPECT for other animals for clinical and research purposes.

Acceso a texto completo
Impact of SARS-CoV-2 on pregnancy and neonatal outcomes: An open prospective study of pregnant women in Brazil
Ursula Trovato Gomez, Rossana Pulcineli Vieira Francisco, Fernanda Spadotto Baptista, Maria Augusta B.C. Gibelli, Silvia Maria Ibidi, Werther Brunow de Carvalho, Cristiane de Freitas Paganoti, Ester Cerdeira Sabino, ... HC-FMUSP-Obstetric COVID-19 Study Group
Clinics. 2022;77C:100073
Highlights

  • COVID-19 increases the rates of adverse pregnancy and neonatal outcomes.

  • Serious cases are associated with oligohydramnios, fetal distress, prematurity, neonatal ICU admission, maternal and neonatal deaths.

  • The maternal clinical status dictates obstetric and neonatal outcomes.

Acceso a texto completo
Expression of ezrin protein and phosphorylated ezrin in pelvic endometriotic lesions
Alessandra Peloggia, Marina Paula Andres, Mauricio Simões Abrão
Clinics. 2022;77C:100074
Highlights

  • The implantation of endometrial cells in the pelvic cavity has been related to some factors such as a receptive environment that allows the implantation and proliferation of these cells.

  • Several studies have shown the participation of the Ezrin protein in the process of invasion of malignant cells.

  • The expression of Ezrin and its activated form was observed in endometriotic lesions providing great evidence that these proteins can play an important role in the migration and attachment of endometriotic lesions.

Acceso a texto completo
Importance of detection of Strongyloides stercoralis DNA in fecal samples from patients with type 2 diabetes mellitus
Márcia Carolina Mazzaro, Émelin Alves dos Santos, Gessica Baptista de Melo, Priscila Duarte Marques, Laura Vilela Souza, Jefferson Elias-Oliveira, Bruna Campos da Silva, Ronaldo César Borges Gryschek, ... Rosângela Maria Rodrigues
Clinics. 2022;77C:100060
HIGHLIGHTS

  • Positivity for strongyloidiasis in coproscopic exam was low in diabetic patients.

  • PCR is more sensitive for detecting S. stercoralis infection in diabetic patients.

  • Molecular diagnosis is an important tool for the detection of S. stercoralis.

Acceso a texto completo
Ambulation capacity, age, immunosuppression, and mechanical ventilation are risk factors of in-hospital death in severe COVID-19: a cohort study
Erika Christina Gouveia e Silva, Ana Carolina Basso Schmitt, Caroline Gil de Godoy, Amislaine Cristina Gambeta, Celso Ricardo Fernandes de Carvalho, Carolina Fu, Clarice Tanaka, Carlos Toufen Junior, ... José Eduardo Pompeu
Clinics. 2022;77C:100075
HIGHLIGHTS

  • Ambulation capacity, race, age, and immunosuppression increase the risk of in-hospital death. How might it impact clinical practice in the future?

  • People with ambulation disabilities should be treated more carefully when they present the first symptoms of COVID-19, due to the high risk of developing a worse prognosis.

  • Pandemic control recommendations should include the population with ambulation disability as a priority group in vaccination against COVID-19

Acceso a texto completo
Intra-articular triamcinolone hexacetonide injections in hands osteoarthritis ‒ A double-blinded randomized controlled trial with a one year follow-up
Natalia de Oliva Spolidoro Paschoal, Jamil Natour, Flavia Soares Machado, Hilda Alcântara Veiga de Oliveira, Artur da Rocha Correa Fernandes, Rita Nely Vilar Furtado
Clinics. 2022;77C:100036
Highlights

  • Hands osteoarthritis treatment.

  • Intra-articular corticosteroid injection.

Acceso a texto completo
Cognitive-behavioral group therapy for women with hypoactive sexual desire: A pilot randomized study
Théo Lerner, Vicente Renato Bagnoli, Elsa Aida Gay de Pereyra, Lucivanda Pontes Fonteles, Isabel Cristina Esposito Sorpreso, José Maria Soares Júnior, Edmund Chada Baracat
Clinics. 2022;77C:100054
Highlights

  • Group cognitive-behavioral therapy (CBT) have a positive influence on women's sexuality.

  • Group CBT was shown to be an effective tool for treating Hypoactive Sexual desire disorder in women.

  • Group CBT can be a short-term focal intervention carried out by gynecologists specialized in sexual health.

  • Group CBT can be used in a high-complexity care setting.

Acceso a texto completo
Two decades of liver resection with a multidisciplinary approach in a single institution: What has changed? Analysis of 1409 cases
Paulo Herman, Gilton Marques Fonseca, Fabricio Ferreira Coelho, Jaime Arthur Pirola Kruger, Fabio Ferrari Makdissi, Vagner Birk Jeismann, Flair José Carrilho, Luiz Augusto Carneiro D'Albuquerque, Sergio Carlos Nahas
Clinics. 2022;77C:100088
Highlights

  • Analysis of changes in hepatectomies during the last 2 decades.

  • The surgical treatment of liver tumors needs a multidisciplinary approach.

Acceso a texto completo
Impact of ERT and follow-up of 17 patients from the same family with a mild form of MPS II
Bruno de Oliveira Stephan, Caio Robledo Quaio, Gustavo Marquezani Spolador, Ana Carolina de Paula, Marco Antônio Curiati, Ana Maria Martins, Gabriela Nunes Leal, Artur Tenorio, ... Chong Ae Kim
Clinics. 2022;77C:100082
Highlights

  • Clinical variability within a large family with a slowly progressive form of MPS II.

  • Despite being safe, ERT with α or β-Idursulfase might not prevent disease progression.

Acceso a texto completo
FOXP3 variants are independently associated with transforming growth factor Β1 plasma levels in female patients with inflammatory bowel disease
Cláudia Junko Inoue, Tamires Flauzino, Beatriz Piantoni Gonçalves, Jaqueline Costa Castardo de Paula, Talita Cristina Galvão, Paula Kikuchi Miyazaki, Camila Cataldi de Alcantara, Lucilene Rosa e Silva Westmore, ... Andréa Name Colado Simão
Clinics. 2022;77C:100084
Highlights

  • FOXP3 variants are associated with susceptibility to IBD.

  • GAGA haplotype is associated with reduced TGF-γ plasma levels in IBD.

  • G/C haplotypes have a protective effect on susceptibility in CD.

Acceso a texto completo
Micro ribonucleic acid-448 regulates zinc finger e-box binding homeobox 1 to inhibit the growth of breast cancer cells and increase their sensitivity to chemotherapy
Yizhou Zhou, Li Sun, Yangmei Zhang, Kai Chen
Clinics. 2022;77C:100089
Highlights

  • MicroRNA-448 expression decreased in Breast Cancer (BC) tissues and BC cells.

  • Zinc finger E-box Binding Homeobox 1 (ZEB1) was upregulated in BC tissues and cells.

  • Upregulation of miR-448 expression could inhibit the malignant behaviors of BC cells.

  • Upregulated miR-448 expression could enhance BC cells’ sensitivity to PTX or 5-FU.

Acceso a texto completo
Risk factors of transplant renal artery stenosis in kidney transplant recipients
Gabriel Kanhouche, Gustavo Rocha Feitosa Santos, Henry Campos Orellana, Attilio Galhardo, Ana Carolina Buso Faccinetto, Manoela Linhares Machado Barteczko, Luiz Sérgio F. de Carvalho, Julia Bernardi Taddeo, ... Adriano Henrique Pereira Barbosa
Clinics. 2022;77C:100087
Highlights

  • TRAS is the most common vascular complication after kidney transplantation.

  • Delayed graft function increases more than 3 times the chance of developing TRAS.

  • Diabetes mellitus and DGF are independent risk factors for post-anastomotic TRAS.

Acceso a texto completo
Resveratrol attenuates chronic pulmonary embolism-related endothelial cell injury by modulating oxidative stress, inflammation, and autophagy
Xiaopeng Liu, Haiying Zhou, Zhixiong Hu
Clinics. 2022;77C:100083
Highlights

  • Resveratrol can effectively improve pulmonary thromboembolism-induced PAEC injury.

  • Resveratrol can reduce pulmonary arterial pressure through a variety of mechanisms.

  • These findings may contribute to the treatment of PH in the future.

Acceso a texto completo
The etiologies of post-stroke depression: Different between lacunar stroke and non-lacunar stroke
Ke-Wu Wang, Yang-Miao Xu, Chao-Bin Lou, Jing Huang, Chao Feng
Clinics. 2022;77C:100095
Highlights

  • The main determinants for depression after lacunar and non-lacunar stroke were different.

  • Infarctions in the frontal cortex were significantly associated with post-stroke depression.

  • For patients of lacunar stroke, the location of the infarction was not associated with the presence of post-stroke depression.

Acceso a texto completo
Effect of MTTP -493G/T, I128T, Q95H and Q244E polymorphisms on hepatic steatosis in patients with chronic hepatitis
Thamiris Vaz Gago Prata, Caroline Manchiero, Bianca Peixoto Dantas, Arielle Karen da Silva Nunes, Fátima Mitiko Tengan, Mariana Cavalheiro Magri
Clinics. 2022;77C:100094
Highlights

  • Important etiologies of chronic liver disease are viral hepatitis.

  • Viral hepatitis B and C causes 1.1 million deaths per year.

  • Hepatic steatosis (liver fat accumulation) is a metabolic complication of hepatitis C.

  • The underlying mechanisms involving steatosis include genetic polymorphisms.

  • -493G/T and I128T polymorphisms in the MTTP gene are relevant in hepatic steatosis.

Acceso a texto completo
Risk factors related to pleural empyema after talc slurry pleurodesis
Paula Duarte D'Ambrosio, Pedro Henrique Xavier Nabuco de Araújo, Eserval Rocha Junior, Mauro Razuk Filho, Paulo Manuel Pêgo-Fernandes, Ricardo Mingarini Terra
Clinics. 2022;77C:100098
Highlights

  • The study's objective was to identify the risk factors for the development of post-pleurodesis empyema in order to better select patients for this procedure and minimize its morbidity. The study suggests that antibiotic therapy prior to pleurodesis may increase the risk of developing empyema. Furthermore, pleurodesis should be carefully considered in patients with long-duration chest tube and incomplete lung expansion.

Acceso a texto completo
Hepatocellular carcinoma (HCC) in patients with Non-Alcoholic Fatty Liver Disease (NAFLD): screening, treatment and survival analysis in a Brazilian series
Regiane Saraiva de Souza Melo Alencar, Claudia P. Oliveira, Aline Lopes Chagas, Leonardo Gomes da Fonseca, Claudia Maccali, Lisa Rodrigues da Cunha Saud, Mariana Pinheiro Xerfan, Jose Tadeu Stefano, ... Flair Jose Carrilho
Clinics. 2022;77C:100097
Highlights

  • Obesity and its related complications are rapidly changing the epidemiology of many types of cancer, including HCC. As a result of this dynamic epidemiology, NAFLD and NASH-related HCC have risen ‒ more rapidly than HCV, HBV, and other HCC's causes.

  • The evaluation of HCC development, the role of screening, treatment, and outcomes on HCC-NAFLD patients is still controversial and not well described.

  • Metabolic risk factors for NAFLD were present in the majority of the patients, even though a small percentage were in HCC screening programs before.

  • Cumulative survival at the end of the first year was 72%, second year 52%, and fifth-year 32%. The independent factors associated with shorter general survival were BCLC C-D, and the size of the largest nodule > 42 mm.

Acceso a texto completo
Reference percentiles for bioimpedance body composition parameters of healthy individuals: A cross-sectional study
Marina Azambuja Amaral, Eduardo Mundstock, Camila H. Scarpatto, Wilson Cañon-Montañez, Rita Mattiello
Clinics. 2022;77C:100078
Highlights

  • Body composition is considered an important predictor in different clinical and health promotion scenarios.

  • This is the first study to describe the reference values of body composition composed of a sample of Brazilians stratified by different life cycles, sex, and race.

  • This is the first study that includes the evaluation of all parameters of body composition assessed from electrical bioimpedance.

Acceso a texto completo
Effect of Beclin-1 gene silencing on autophagy and apoptosis of the prostatic hyperplasia epithelial cells
Rongfu Liu, Song Zhang, Rui Wan, Jiang Deng, Wei Fang
Clinics. 2022;77C:100076
Highlights

  • • Beclin-1 gene silencing could reduce the autophagy level of BPH-1 cells.

  • • Beclin-1 gene silencing could promote the apoptosis of BPH-1 cells.

  • • There is an antagonisc relationship between autophagy and apoptosis in BPH-1 cells.

Acceso a texto completo
Long non-coding RNA SNHG1 promotes bladder cancer progression by upregulating EZH2 and repressing KLF2 transcription
Jie Min, Jiaxing Ma, Qi Wang, Dexin Yu
Clinics. 2022;77C:100081
Highlights

  • lncRNA SNHG1 played an oncogenic role in bladder cancer, indicating poor prognosis.

  • SNHG1 competitively bound miR-137-3p to promote EZH2 expression in the cytoplasm.

  • SNHG1 could interact with EZH2 to inhibit KLF2 transcription in the nucleus.

Acceso a texto completo
Clinical significance of circulating tumor cells in predicating the outcomes of patients with colorectal cancer
Kehe Chen, Zhenxiang Chen, Mei Ou, Junping Wang, Xiao Huang, Yingying Wu, Wenhe Zhong, Jiao Yang, ... Deng Pan
Clinics. 2022;77C:100070
HIGHLIGHTS

  • Total CTCs and MCTCs in post-treatment is strongly relative to PFS and OS of patients.

  • The PFS of >6 CTCs or 5 MCTCs/5 mL blood was shorter than that in ≤ 6 CTCs or 5 MCTCs.

  • Detection of CTCs in CRC patients is a critical biomarker for their prognosis.

Acceso a texto completo
Surfactant Protein (SP) induces preterm birth by promoting oxidative stress via upregulating Storkhead-Box Protein 1
Xiafang Li, Chunnian Zhang
Clinics. 2022;77C:100079
HIGHLIGHTS

  • SP-A induced pathological damage to placenta by promoting STOX1.

  • SP-A inhibited the activities of antioxidant enzymes through STOX1.

  • SP-A promoted the ROS production in placenta by promoting STOX1.

  • SP-A inhibited protein levels of NOS3 and ARG2 in placenta.

Acceso a texto completo
Is 12 months enough to reach function after athletes’ ACL reconstruction: a prospective longitudinal study
Ellen Cristina Rodrigues Felix, Angelica Castilho Alonso, Guilherme Carlos Brech, Tiago Lazzaretti Fernandes, Adriano Marques de Almeida, Natália Mariana Silva Luna, Jose Maria Soares-Junior, Edmund Chada Baracat, ... Júlia Maria D'Andrea Greve
Clinics. 2022;77C:100092
Highlights

  • Anterior cruciate ligament injury is disabling in several sports.

  • nterior cruciate ligament injury causes knee instability and functional deficit.

  • Usually, surgical treatments produce best functional outcomes.

Acceso a texto completo
Hemodynamic depression after carotid surgery: Incidence, risk factors and outcomes
Lauro A.C. Bogniotti, Marcelo P. Teivelis, Francisco A.M. Cardozo, Bruno Caramelli, Nelson Wolosker, Pedro Puech-Leão, Nelson De Luccia, Daniela Calderaro
Clinics. 2022;77C:100090
Highlights

  • Incidence of Hemodynamic Depression was 54.4% in 237 carotid surgeries.

  • Asymptomatic carotid stenosis and endovascular surgery were predictors of HD.

  • Hypotension requiring continuous vasopressor infusion was associated with MACE.

Acceso a texto completo
LHX1 as a potential biomarker regulates EMT induction and cellular behaviors in uterine corpus endometrial carcinoma
Ye Tian, Fang Wen, Shuo Wang, Na Lv
Clinics. 2022;77C:100103
Highlights

  • LHX1 is highly upregulated in the cells and tissues of Uterine Corpus Endometrial Carcinoma (UCEC).

  • Upregulation of LHX1 is correlated with poor prognosis of UCEC patients.

  • LHX1 may regulate UCEC progression at least partly by modulating EMT induction.

Acceso a texto completo
Isolated specific IgA against respiratory viruses, Influenza or SARS-CoV-2, present in the saliva of a fraction of healthy and asymptomatic volunteers
Nahiara Esteves Zorgi, Luciana R. Meireles, Danielle Bruna Leal Oliveira, Danielle Bastos Araujo, Edson L. Durigon, Heitor Franco de Andrade Junior
Clinics. 2022;77C:100105
Highlights

  • Natural antigen ELISA detected saliva IgG or IgA against respiratory viruses in asymptomatic people from Influenza and COVID.

  • Samples with specific influenza IgG were more frequent than COVID IgG, probably due to long time exposure to influenza, but samples positive for specific IgA had same proportion for both viruses.

Acceso a texto completo
The postoperative cognitive dysfunction induced by central inflammation with possible involvement of the gut-brain axis
Chuantao Lin, Jing Wang, Yuping Wang, Chanjuan Chen, Xiang Gao
Clinics. 2022;77C:100104
Highlights

  • POCD has a significant impact on patients' physical and mental health.

  • Postoperative models of tibial fracture in aged rats were established.

  • Postoperative central inflammation in rats with lower limb fracture induced POCD through the GBA molecular mechanism.

Acceso a texto completo
Wound healing in weaning, adult, and old rats with provoked incisional hernias. A comparative study
Raphael Nogueira do Amaral, Ana Cristina Aoun Tannuri, Junia Marielle Teixeira Rodrigues Neri, Hugo de Souza Reis, Josiane Oliveira Gonçalves, Suellen Serafini, Uenis Tannuri
Clinics. 2022;77C:100106
Highlights

  • Lower incidence of incisional hernias in pediatric patients.

  • Greater proliferation of fibroblasts in younger rats.

  • Lox gene is more expressed in weaning rats.

Acceso a texto completo
Evaluation of breast stiffness pathology based on breast compression during mammography: Proposal for novel breast stiffness scale classification
Jiří Prokop, Pavel Maršálek, Ilker Sengul, Anton Pelikán, Jana Janoutová, Petr Horyl, Jan Roman, Demet Sengul, José Maria Soares Junior
Clinics. 2022;77C:100100
Highlights

  • Breast stiffness severely affects clinical- and self-examination of the breast.

  • Development of subjective stiffness scale based on expert examination.

  • Objective stratification based on interval of increment of strain energy density.

  • Proposed scale correlates with subjective clinical examination in 92%.

  • Women with stiff breasts may benefit from frequent checkup procedures.

Acceso a texto completo
Clinical relevance of miR-423-5p levels in chronic obstructive pulmonary disease patients
Xin Zhang, Qing Shi, Lu Xiong, Shiye Shi, Yong Li, Yanhuan Wang, Mingchuan Zhang
Clinics. 2022;77C:100102
Highlights

  • Relationship of plasma miR-423-5p expression in COPD patients as well as smoking history.

  • 9 miRNAs were dysregulated in COPD patients.

  • miR-423-5p has potential value as a clinical diagnosis of COPD.

Acceso a texto completo
Comparative effects of fractional radiofrequency and microneedling on the genitalia of postmenopausal women: Histological and clinical changes
Rafaella Rêgo Maia, Ayane Cristine Sarmento, Rodrigo Marcel Valentim da Silva, Eneida de Morais Carreiro, Stephany Luanna Queiroga Farias, Ciro Dantas Soares, Patrícia Froes Meyer, Ana Katherine Gonçalves
Clinics. 2022;77C:100117
Highlights

  • Radiofrequency is effective in flaccidity.

  • Radiofrequency provokes collagen remodeling.

Acceso a texto completo
Higher visceral adiposity index is associated with increased likelihood of abdominal aortic calcification
Zheng Qin, Luojia Jiang, Jiantong Sun, Jiwen Geng, Shanshan Chen, Qinbo Yang, Baihai Su, Ruoxi Liao
Clinics. 2022;77C:100114
Highlights

  • Higher Adiposity Index (VAI) tertile shows higher rates of Abdominal Aortic Calcification (AAC).

  • Each unit increase in VAI was associated with 4% higher likelihood of severe AAC.

  • Increased visceral adiposity evaluating by VAI associated with a higher AAC score.

  • This positive relationship was more significant in normal weight population.

Acceso a texto completo
Relationship between lipoprotein (a) and subclinical carotid atherosclerosis in asymptomatic individuals
Victor França, Érica Ivana Lázaro Gomes, Edite Vieira Silva de Campos, Vanessa Helena de Souza Zago, Valéria Sutti Nunes, Eliana Cotta de Faria
Clinics. 2022;77C:100107
Highlights

  • High lipoprotein (a) levels increase the risk of carotid plaques presence in asymptomatic subjects.

  • Carotid intima-media thickness is not affected by plasma lipoprotein (a) levels.

  • Age and race are directly associated with lipoprotein (a) levels, suggesting an important influence even in a highly miscegenated population.

Acceso a texto completo
COVID-19 post-vaccination in healthcare workers and vaccine effectiveness, Brazil, 2021
Caio Medeiros Fernandes, Shirley L. Dias, Maira C. Ferreira, Expedito J.A. Luna
Clinics. 2022;77C:100109
Highlights

  • Vaccination with any vaccine was effective in preventing confirmed COVID-19 cases.

  • CoronaVac was effective in preventing COVID-19 related hospitalizations.

  • Vaccination had a significant impact in reducing cases and hospitalizations.

  • Predominance of mild cases, with respiratory symptoms, myalgia, and headache.

  • Vaccine protection waned over time.

Acceso a texto completo
Seroconversion in asymptomatic COVID-19 pediatric patients with rheumatic diseases of one tertiary referral hospital
Juliana R. Simon, Maria F.B. Pereira, Heloisa H. Marques, Adriana M. Elias, Neusa K. Sakita, Juliana C.O.A. Ferreira, Alexander Roberto Precioso, Sandra J.F.E. Grisi, ... Lúcia M.A. Campos
Clinics. 2022;77C:100110
Highlights

  • The study evaluated seroconverted asymptomatic COVID-19 in pediatric Autoimmune Rheumatic Diseases (ARDs) patients.

  • Pediatric rheumatic disease patients were infected at the same rate as healthy ones.

  • Neither the underlying pathology nor its immunosuppressive treatment seemed to interfere with contagion risk.

Acceso a texto completo
Melatonin protects against ovarian damage by inhibiting autophagy in granulosa cells in rats
Yan Liu, Xiaohe Zhu, Chunli Wu, Yan Lang, Wenjie Zhao, Yanmin Li
Clinics. 2022;77C:100119
Highlights

  • Melatonin (MT) plays a similar role in ovarian damage as 3-MA does.

  • MT confers protection against ovarian damage in vivo and in vitro.

  • MT exerts its protective effects by inhibiting the PI3K/AKT/mTOR signaling pathway.

Acceso a texto completo
Effects of oxytocin versus promestriene on genitourinary syndrome: a pilot, prospective, randomized, double-blind study
Liani Patricia Andrade Santos, Claudio Emílio Bonduki, Rita de Cássia de Maio Dardes, Thais Heinke, Marisa Teresinha Patriarca
Clinics. 2022;77C:100116
Highlights

  • Prospective, double-blind, randomized pilot study.

  • Compares efficacy of oxytocin and promestriene in Genitourinary Menopause Syndrome.

  • The two medications improved the three domains of the FSFI scales scores evaluated.

  • Both medications showed an increase in the thickness of the vaginal epithelium (p < 0.05).

  • Oxytocin and promestriene were both effective in Genitourinary Menopause Syndrome.

Acceso a texto completo
Central auditory processing in children after traumatic brain injury
Carolina Calsolari Figueiredo de Godoy, Adriana Neves de Andrade, Italo Suriano, Carla Gentile Matas, Daniela Gil
Clinics. 2022;77C:100118
Highlights

  • Central auditory processing disorder was detected in all the individuals in the study group.

  • The study group had worse performance with a statistically significant difference.

  • The changes especially are in auditory closure and temporal processing as compared to the control group.

Acceso a texto completo
MiR-135a-5p suppresses breast cancer cell proliferation, migration, and invasion by regulating BAG3
Hongxu Zhang, Minghui Wang, Zhiqiang Lang, Haiwang Liu, Jianping Liu, Lihui Ma
Clinics. 2022;77C:100115
Highlights

  • MiR-135a-5p was significantly down-regulated and BAG3 expression was significantly raised in BC tissues.

  • MiR-135a-5p overexpression inhibited the viability, migration and aggressiveness of BC cells, and blocked cell cycle progression in G0/G1 phase.

  • Over-expression of BAG3 reversed the impacts of miR-135a-5p on BC cells.

Acceso a texto completo
miRNA-223 expression in patient-derived eutopic and ectopic endometrial stromal cells and its effect on epithelial-to-mesenchymal transition in endometriosis
Yuan Xue, Xueyan Lin, Tingting Shi, Yongjie Tian
Clinics. 2022;77C:100112
Highlights

  • miRNA-223 was downregulated in endometrial stromal ells from endometriosis patients.

  • miRNA-223 upregulation repressed malignant behaviors of endometrial stromal cells.

  • miRNA-223 might serve as a potential therapeutic target for endometriosis.

Acceso a texto completo
Monocyte-to-HDL ratio and non-HDL cholesterol were predictors of septic shock in newborns
Fernanda Andrade Macaferri da Fonseca, Aline Paulino Espósito, Maria Helena Baptista Nunes da Silva, Valéria Sutti Nunes, Patricia Miralda Cazita, Guilherme Silva Ferreira, Maria Esther Jurfest Rivero Ceccon, Werther Brunow de Carvalho, ... Patricia Palmeira
Clinics. 2022;77C:100111
Highlights

  • Profound changes in lipid profile have been described in septic patients.

  • Lipid profile was equivalent between septic and control groups.

  • Septic shock group showed lower TG, HDLc, monocytes and M/H ratio and higher CRP, IL-6, IL-8 and IL-10 levels at admission.

  • All lipid variables decreased from D0 to D3 in the shock group.

  • M/H ratio and non-HDL cholesterol were predictors of shock in septic newborns.

Acceso a texto completo
The health facility as a risk factor for multidrug-resistant gram-negative bacteria in critically ill patients with COVID-19
Viviane de Macedo, Gabriela de Souza dos Santos, Rodolff Nunes da Silva, Caio Nogara de Menezes Couto, Camila Bastos, Eloize Viecelli, Marina do Nascimento Mateus, Maria Esther Graf, ... Anna S. Levin
Clinics. 2022;77C:100130
Highlights

  • Critically ill patients with COVID-19 can have secondary infections.

  • Some of them are caused by Multidrug-Resistant (MDR) Gram-Negative Bacteria (GNB).

  • To know the risk factors related to MDR-GNB is essential to analyze if it is possible to prevent them.

  • Hospital of admission for patients with COVID-19 posed as high risk for MDR-GNB.

  • This is a modifiable risk factor.

Acceso a texto completo
TRIM47 promotes ovarian cancer cell proliferation, migration, and invasion by activating STAT3 signaling
Xi Wang, Yu Fu, Yanyan Xing
Clinics. 2022;77C:100122
Highlights

  • Knockdown of TRIM47 suppressed proliferation of ovarian cancer cells.

  • Knockdown of TRIM47 inhibited ovarian cancer cell migration and invasion.

  • TRIM47 promoted ovarian cancer cell proliferation and invasion via STAT3 signaling.

Acceso a texto completo
Targeted massively parallel sequencing panel to diagnose genetic endocrine disorders in a tertiary hospital
Amanda M. Narcizo, Lais C. Cardoso, Anna F.F. Benedetti, Alexander A.L. Jorge, Mariana F.A. Funari, Barbara L. Braga, Monica M. Franca, Luciana R. Montenegro, ... Berenice B. Mendonca
Clinics. 2022;77C:100132
Highlights

  • The multigenic panel effectively diagnoses patients with endocrine diseases.

  • It is the first panel to diagnose a broad spectrum of endocrine diseases using TMPS.

  • This panel helps the visualization of molecular pathways behind endocrine conditions.

Acceso a texto completo
Clinical and anatomical characteristics associated with obstructive sleep apnea severity in children
Maria Fernanda Bozzini, Renata C. Di Francesco, Letícia A. Soster
Clinics. 2022;77C:100131
Highlights

  • Untreated obstructive sleep apnoea in children may result in severe health consequences, including cardiovascular, metabolic, endocrine and growth abnormalities.

  • Other sleep impairments may be associated with obstructive sleep apnoea, affecting children's quality of life.

  • Polysomnography is the gold standard for diagnosis, but it is costly and not widely available.

  • Other studies that contribute to the diagnosis process are relevant and of great importance.

Acceso a texto completo
The supplementation of L-carnitine in septic shock patients: Systematic review and meta-analysis
Gabriel Voltani Guedes, Marcos Ferreira Minicucci, Suzana Erico Tanni
Clinics. 2022;77C:100124
Highlights

  • The objective of this review was to evaluate the effect of L-carnitine compared to placebo or Usual Care (UC) on the mortality rate in hospitalized adult septic shock patients. •Two Randomized Controlled Trials were selected for inclusion in this review •There is low-quality evidence that L-carnitine has no significant effect on 28-day mortality of septic shock patients

Acceso a texto completo
The variability of isokinetic ankle strength is different in healthy older men and women
Felipe Marrese Bersotti, Luis Mochizuki, Guilherme Carlos Brech, André Luiz de Seixas Soares, Jose Maria Soares-Junior, Edmund Chada Baracat, Julia Maria D'Andrea Greve, Angelica Castilho Alonso
Clinics. 2022;77C:100125
Highlights

  • Older men are stronger than older women.

  • Higher torque variability in older men.

  • Adaptation to the isokinetics evaluation.

  • Different muscles need different numbers of sets.

  • Different muscles need different numbers of trials.

Acceso a texto completo
Prevalence of oncogenic human papillomavirus in pregnant adolescents, association with colpocytological changes, risk factors and obstetric outcomes
Henrique Diório de Souza, Adriana Lippi Waissman, Giselle Rodrigues Mota Diório, Stela Verzinhasse Peres, Rossana Pulcineli Vieira Francisco, Marco Aurélio Knippel Galletta
Clinics. 2022;77C:100127
Highlights

  • One out of every two pregnant adolescents (50.5%) followed in prenatal care were positive for high-risk HPV and about 1 in 6 pregnant women (17.5%) had an abnormal Pap smear.

  • Positivity for oncogenic HPV was an important risk factor for colpocytological alterations, especially for Low-grade Squamous epithelial Lesion (LSIL), increasing the risk by nine times.

  • Higher education, fewer lifetime partners, and profession of religion were associated with the diagnosis of oncogenic HPV in pregnancy.

Acceso a texto completo
Diagnosis of parapneumonic pleural effusion with serum and pleural fluid Activin A
Guanghui Zhou, Kan Liu, Xiuhai Ji, Yan Fen, Yinjie Gu, Hui Ding
Clinics. 2022;77C:100133
Highlights

  • Higher concentrations of Activin A in pleural effusion were associated with days of admission in PPE patients.

  • Elevated levels of Activin A in pleural effusion exhibited 93% sensitivity and 84% specificity in the diagnosis of PPE.

  • Pleural fluid Activin A level had higher AUC and better accuracy in the diagnosis of PPE.

Acceso a texto completo
Clinical characteristics and evolution of 71 neonates born to mothers with COVID-19 at a tertiary center in Brazil
Bruna de Paula Duarte, Vera Lucia Jornada Krebs, Valdenise Martins Laurindo Tuma Calil, Werther Brunow de Carvalho, Maria Augusta Bento Cicaroni Gibelli, Rossana Pulcineli Vieira Francisco
Clinics. 2022;77C:100136
Highlights

  • This study's main objective is to describe the clinical characteristics and evolution from birth to discharge of 71 neonates born to unvaccinated women with COVID-19 with RT-PCR for SARS-CoV-2 positive within fourteen days prior to delivery in a Brazilian hospital.

  • The neonatal SARS-CoV-2 positivity rate was 2.8% and these newborns had few clinical symptoms.

  • The prematurity rate was 63.4%, indicating that maternal disease may lead to neonatal complications associated with a higher prematurity rate.

Acceso a texto completo
A meta-analysis of the effect of Sjögren′s syndrome on adverse pregnancy outcomes
Baoqing Geng, Keyue Zhang, Xianqian Huang, Yong Chen
Clinics. 2022;77C:100140
Highlights

  • Dry syndrome can increase the risk of spontaneous abortion and preterm delivery.

  • Dry syndrome can increase the risk of low birth weight and birth defects.

  • Clinics should provide comprehensive prenatal counseling and testing for the patients.

Acceso a texto completo
High expression of prolyl 4-hydroxylase subunit alpha-2 in lung adenocarcinoma indicates poor prognosis
Xiao-Hong Lu, Die Sang, Yu-Rong Zhang, Qing Yuan
Clinics. 2022;77C:100123
Highlights

  • P4HA2 is highly expressed in LUAD tumor cells, especially for the BM subtype.

  • P4HA2 is a valuable prognostic indicator for LUAD.

  • P4HA2 is related to biological processes promoting metastasis.

Acceso a texto completo
Adolescents’ knowledge of HPV and sexually transmitted infections at public high schools in São Paulo: A cross-sectional study
Jose Maria Soares Junior, Hervillin Maria Creusa de Oliveira, Camilla Maganhin Luquetti, Lea Tami Suzuki Zuchelo, Eduardo Carvalho de Arruda Veiga, Juliana Zangirolami Raimundo, Francisco Winter dos Santos Figueiredo, Mayara Souza Alves, ... Edmund Chada Baracat
Clinics. 2022;77C:100138
Highlights

  • Adolescents’ knowledge of HPV.

  • Adolescents’ knowledge of sexually transmitted diseases.

  • Female adolescents’ knowledge of HPV and sexually transmitted diseases.

  • Male adolescents’ knowledge of HPV and sexually transmitted diseases.

Acceso a texto completo
Relevant proteins for the monitoring of engraftment phases after allogeneic hematopoietic stem cell transplantation
Milena Monteiro Souza, Cláudia Malheiros Coutinho-Camillo, Fabiana Martins de Paula, Fernanda de Paula, Sheyla Batista Bologna, Silvia Vanessa Lourenço
Clinics. 2022;77C:100134
Highlights

  • The protein analysis reveals dynamic changes in the three different phases in response to allo-HSCT.

  • The most identified proteins were involved with the regulation of body fluid levels and mucosal immune response.

  • The allo-HSCT patients presented a decreased salivary flow rate at 30 and 100 days post-transplant.

Acceso a texto completo
Methylene Blue to Neonatal Septic Shock treatment in neonate pigs,
Walusa Assad Gonçalves-Ferri, Agnes Afrodite Sumarelli Albuquerque, Renata Sayuri Ansai Pereira de Castro, Cristina Helena Faleiros Ferreira, Luis K. Oharomari, Diego Fernando Silva Lessa, Paulo Roberto Barbosa Evora
Clinics. 2022;77C:100139
Highlights

  • MB improved septic shock biomarkers associated with microcirculation, however, did not improve blood pressure.

  • The MB was not associated with pulmonary hypertension and respiratory clinical repercussions.

  • The MB did not decrease the heart inotropic or chronotropic aspects.

Acceso a texto completo
Review articles
From H1N1 to COVID-19: What we have seen in children with hemoglobinopathies
Claudia de Melo Oliveira, Victor Jablonski Soares, Ciliana Rechenmacher, Liane Esteves Daudt, Mariana Bohns Michalowski
Clinics. 2022;77C:100004
Highlights

  • Children with hemoglobinopathies have less severe conditions with Coronavirus 2019 Disease (COVID-19) compared to adults, which is similar to that observed in the general population

  • In the H1N1 pandemic, patients with hemoglobinopathies behaved as the group most susceptible to complications, with increased morbidity and mortality

Acceso a texto completo
Sudden unexpected death in Parkinson's disease: Insights from clinical practice
Fulvio A. Scorza, Marcia Guimarães-Marques, Mariana Nejm, Antônio Carlos G. de Almeida, Carla A. Scorza, Ana C. Fiorini, Josef Finsterer
Clinics. 2022;77C:100001
Acceso a texto completo
Ischemic stroke in 455 COVID-19 patients
Josef Finsterer, Fulvio Alexandre Scorza, Carla Alessandra Scorza, Ana Claudia Fiorini
Clinics. 2022;77C:100012
Highlights

  • Ischemic stroke in COVID-19 is multifactorial but predominantly embolic.

  • Ischemic stroke in COVID-19 predominantly affects males and the anterior circulation.

  • Frequency of ischemic stroke has not increased since the outbreak of the pandemic.

Acceso a texto completo
Arterial stiffness and atrial fibrillation: A review
João Gabriel Batista Lage, Alexandre Lemos Bortolotto, Mauricio Ibrahim Scanavacca, Luiz Aparecido Bortolotto, Francisco Carlos da Costa Darrieux
Clinics. 2022;77C:100014
Highlights

  • The increase of arterial stiffness at younger ages has been considered a strong predictor of cardiovascular outcomes.

  • Elevated “pulsatile load”, which translates into elevated arterial stiffness, would lead to a cascade of phenomena (left atrium distension, neurohormonal activation and inflammatory response), that in their final common path would lead to the development of atrial fibrillation.

  • A genetic predisposition for a higher arterial stiffness index was unidirectionally associated with an increase in incidence risk and prevalence of atrial fibrillation. These results are consistent with a causality association between arterial stiffness and atrial fibrillation.

  • A knowledge gap to be clarified is whether a reduction in arterial stiffness could lead to a decrease in atrial arrhythmia burden, from frequent atrial ectopic beats to atrial fibrillation. Another knowledge gap is the possible rule of arterial stiffness in the so-called “pre-fibrillatory stage”.

Acceso a texto completo
Comparing dextrose prolotherapy with other substances in knee osteoarthritis pain relief: A systematic review
Vitor Santos Cortez, Walter Augusto Moraes, João Victor Taba, Alberto Condi, Milena Oliveira Suzuki, Fernanda Sayuri do Nascimento, Leonardo Zumerkorn Pipek, Vitoria Carneiro de Mattos, ... Leandro Ryuchi Iuamoto
Clinics. 2022;77C:100037
Highlights

  • Dextrose injections promote deposition of collagen into injured structures through growth factors and inflammatory cells.

  • Dextrose-prolotherapy is a useful treatment method, but it is not superior or inferior to its counterparts.

Acceso a texto completo
Efficacy and safety in the use of intraperitoneal hyperthermia chemotherapy and peritoneal cytoreductive surgery for pseudomyxoma peritonei from appendiceal neoplasm: A systematic review
Idevaldo Floriano, Antônio Silvinato, João C. Reis, Claudia Cafalli, Wanderley Marques Bernardo
Clinics. 2022;77C:100039
Highlights

  • Hyperthermia chemotherapy and cytoreductive surgery in patients with peritoneal pseudomyxoma.

Acceso a texto completo
Medical errors, medical negligence and defensive medicine: A narrative review
Ivan Dieb Miziara, Carmen Silvia Molleis Galego Miziara
Clinics. 2022;77C:100053
HIGHLIGHTS

  • This article defines medical errors and medical responsibility from a Brazilian perspective.

  • This article calls attention to the risks of medical liability and the unethical use of defensive medicine.

  • The authors propose some procedures and attitudes to avoid medical errors like the use of technology at the bedside and computer-based protocols.

  • The authors state that a good and ethical medical practice can avoid medical liability.

Acceso a texto completo
SARS-CoV-2 vaccinations reduce the prevalence of post-COVID Guillain-Barre syndrome
Josef Finsterer, Daniel Matovu, Fulvio A. Scorza
Clinics. 2022;77C:100064
Highlights

  • SARS-CoV-2 infections can be complicated by Guillain-Barre Syndrome (GBS).

  • The prevalence of SARS-CoV-2 associated GBS declined since the introduction of SARS-CoV-2 vaccines.

  • The outcome of SARS-CoV-2 associated GBS is worse among those with comorbidities compared to those without.

Acceso a texto completo
Efficacy and safety of potassium-competitive acid blockers versus proton pump inhibitors as Helicobacter pylori eradication therapy: a meta-analysis of randomized clinical trials
Mengran Zhang, Mingge Pang, Mei Zhang
Clinics. 2022;77C:100058
HIGHLIGHTS

  • The efficacy of P-CAB-based triple therapy is superior to that of PPI-based triple therapy as a first-line approach to H. pylori eradication, particularly in Japanese patients.

  • P-CABs were not superior to PPIs as a salvage triple eradication therapy.

  • The safety and tolerability of P-CAB are comparable to PPI in H. pylori triple eradication therapies.

  • Further large RCTs conducted in multiple regions and countries are necessary.

Acceso a texto completo
Liver transplant after SARS-CoV-2 infection: A systematic review
Lucas S. Nacif, Michel Ribeiro Fernandes, Daniel R. Waisberg, Rafael S. Pinheiro, Vinicius Rocha-Santos, Flávio Galvão, Wellington Andraus, Luiz Carneiro-D'Albuquerque
Clinics. 2022;77C:100042
Highlights

  • The Coronavirus 19 (COVID-19) pandemic has dramatically impacted liver organ transplantation.

  • This study systematically reviewed the current knowledge regarding the Liver Transplantation (LT) time for patients after COVID-19.

  • Furthermore, the authors provide more knowledge to the transplant physicians with essential decision-making tools to manage these critically ill patients during the pandemic.

Acceso a texto completo
Cervical cancer screening in low- and middle-income countries: A systematic review of economic evaluation studies
Carmen Phang Romero Casas, Rita de Cássia Ribeiro de Albuquerque, Rafaela Borge Loureiro, Angela Maria Gollner, Marina Gonçalves de Freitas, Graciela Paula do Nascimento Duque, Juliana Yukari Kodaira Viscondi
Clinics. 2022;77C:100080
Highlights

  • Screening and early detection programs are a cornerstone of cervical cancer prevention.

  • Human papillomavirus DNA-based testing reduced the incidence of CC below per capita GDP.

  • Cost-effectiveness of HPV testing versus cytology in Low- and Middle-Income Countries.

Acceso a texto completo
Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milk
Yingying Zheng, Simone Correa-Silva, Patricia Palmeira, Magda Carneiro-Sampaio
Clinics. 2022;77C:100093
Highlights

  • Human milk is an essential source of immunonutrients for the nursing infant.

  • Maternal vaccination provides specific IgA and IgG antibodies in breast milk.

  • Milk from vaccinated mothers contains anti-SARS-CoV-2 antibodies that may protect the infant.

Acceso a texto completo
MICRObiota on BILIOpancreatic malignant diseases [MICROBILIO]: A systematic review
Vitoria Carneiro de Mattos, Fernanda Sayuri do Nascimento, Milena Oliveira Suzuki, João Victor Taba, Leonardo Zumerkorn Pipek, Walter Augusto Fabio Moraes, Vitor Santos Cortez, Márcia Saldanha Kubrusly, ... Wellington Andraus
Clinics. 2022;77C:100101
Highlights

  • Microbial agents and their metabolites are being tested to develop treatments that can reduce the tumor and are potentially preventable.

  • Microbiota is observed in all clinical and pathological stages of carcinogenesis, from its development, diagnosis, and treatment, including prognosis and survival.

  • There is a lack of studies on biliary microbiota and its relationship with hepatobiliopancreatic diseases.

Acceso a texto completo
The impact of multivisceral liver resection on short- and long-term outcomes of patients with colorectal liver metastasis: A systematic review and meta-analysis
Sérgio Silveira Júnior, Francisco Tustumi, Daniel de Paiva Magalhães, Vagner Birk Jeismann, Gilton Marques Fonseca, Jaime Arthur Pirola Kruger, Fabricio Ferreira Coelho, Paulo Herman
Clinics. 2022;77C:100099
Highlights

  • Multivisceral liver resections have acceptable long-term oncologic outcomes.

  • Multivisceral liver resections are safe. They have similar rates of blood loss and postoperative complications.

  • Multivisceral liver resections are longer and may be associated with a longer length of hospital stay.

Acceso a texto completo
Effectiveness of neuromuscular electrostimulation in COPD subjects on mechanical ventilation. A systematic review and meta-analysis
Ruvistay Gutiérrez-Arias, Yorschua Jalil, Rocío Fuentes-Aspe, Pamela Seron
Clinics. 2022;77C:100108
Highlights

  • NMES may improve functional independence and decrease in adults with COPD.

  • NMES may decrease in duration of MV in adults with COPD.

  • More RCTs with a better methodological design are needed.

Acceso a texto completo
Inhibition of Toll-like Receptor-4 expression for amelioration of myocardial injury in diabetes: A meta-analysis
Jinxin Yuan, Xingwen Yin, Hua Jiang
Clinics. 2022;77C:100137
Highlights

  • A meta-analysis was applied to understand the relationship between inhibition of Toll-like Receptor 4 and diabetic myocardial injury.

  • Inhibition of Toll-like Receptor 4 expression levels can improve the degree of cardiac impairment.

  • Toll-like Receptor 4 may become a new target for the treatment of diabetic cardiomyopathy.

Acceso a texto completo
Comments
Stigma in Parkinson's disease: Placing it outside the body
Tomás de la Rosa, Fúlvio Alexandre Scorza
Clinics. 2022;77C:100008
Acceso a texto completo
Patient with agammaglobulinemia produces anti-SARS-CoV-2 reactive T-cells after CoronaVac vaccine
Telma Miyuki Oshiro, Lais Teodoro da Silva, Marina Mazzilli Ortega, Sandro Felix Perazzio, Alberto Jose da Silva Duarte, Magda Carneiro-Sampaio
Clinics. 2022;77C:100007
Acceso a texto completo
Artificial intelligence in the medical profession: ready or not, here AI comes
Aidan Pucchio, Joshua Del Papa, Fabio Ynoe de Moraes
Clinics. 2022;77C:100010
Acceso a texto completo
Time-to-event assessment for the discovery of the proper prognostic value of clinical biomarkers optimized for COVID-19
José Raniery Ferreira Junior
Clinics. 2022;77C:100009
Acceso a texto completo
Care coordination in pediatrics: Experience of the outpatient clinic for Children with Special Health Care Needs (CSHCN)
Ana Paula Scoleze Ferrer, Daleth Rodrigues Scaramuzzi, Maria Lúcia M. Bourroul, Sandra M.C. Zuccolotto, Sandra J.F.E. Grisi
Clinics. 2022;77C:100049
Acceso a texto completo
Palliative care in the COVID-19 pandemic: Strategy of HCFMUSP
Ricardo Tavares de Carvalho, Douglas Henrique Crispim, Ednalda Maria Franck, Daniel Battacini Dei Santi, Sergio Seiki Anagusko, Márcio Veronesi Fukuda, Luciana Suelly Barros Cavalcante, Sumatra Melo da Costa Pereira Jales, ... Eloisa Silva Dutra de Oliveira Bonfá
Clinics. 2022;77C:100050
Acceso a texto completo
Long COVID-19: Rethinking mental health
Miguel Gallegos, Nelson Portillo, Pablo Martino, Mauricio Cervigni
Clinics. 2022;77C:100067
Acceso a texto completo
Sudden unexpected death in epilepsy and abnormal glucose metabolism in the rat insular cortex: A brain within the heart
Fulvio A. Scorza, Antonio-Carlos G. de Almeida, Carla A. Scorza, Josef Finsterer
Clinics. 2022;77C:100059
Acceso a texto completo
Comments: Myositis-specific and myositis-associated autoantibody profiles and their clinical associations in a large series of patients with polymyositis and dermatomyositis
Bruno Silva de Araujo Ferreira, Bernardo Matos da Cunha, Larissa Aniceto Moreira, Michel Fabrício Silveiro e Fonseca, Eduardo Boiteux Uchôa Cavalcante
Clinics. 2022;77C:100077
Acceso a texto completo
“Similia Similibus Curentur”: The scientific grounding of the homeopathic therapeutic principle through the systematic study of the rebound effect of modern drugs
Marcus Zulian Teixeira
Clinics. 2022;77C:100091
Highlights

  • Homeopathy employs the principle of therapeutic similitude as a method of treatment.

  • Primary action of drugs is followed by secondary and opposite reaction of the organism.

  • This secondary and opposite reaction of the organism is namely the rebound effect of drugs.

  • Homeopathy employs the rebound effect of drugs in a therapeutic way.

Acceso a texto completo
The implication of cardio-oncology on Parkinson's disease: answers begin to emerge
Fulvio A. Scorza, Antonio-Carlos G. de Almeida, Josef Finsterer, Ludhmila A. Hajjar
Clinics. 2022;77C:100085
Acceso a texto completo
We need to talk about critical care in Brazil
Luiz Alberto Cerqueira Batista Filho, Varinder Kaur Randhawa, Alexandre Toledo Maciel, Marcelo Rocha Coimbra
Clinics. 2022;77C:100096
Acceso a texto completo
Guillain-Barre syndrome related to SARS-CoV-2 vaccinations
Josef Finsterer, Carla A. Scorza, Fulvio A. Scorza
Clinics. 2022;77C:100113
Acceso a texto completo
Developmental and Behavioral Pediatrics: an emerging subspecialty. Experience of the Instituto da Criança e do Adolescente — ICr-HCFMUSP
Ana Paula Scoleze Ferrer, Sandra Josefina Ferraz Ellero Grisi
Clinics. 2022;77C:100126
Acceso a texto completo
Erratums
Erratum to Persistent symptoms and decreased health-related quality of life after symptomatic pediatric COVID-19: A prospective study in a Latin American tertiary hospital” [Clinics. 2021;76:e3511]
Thais T. Fink, Heloisa H.S. Marques, Bruno Gualano, Livia Lindoso, Vera Bain, Camilla Astley, Fernanda Martins, Denise Matheus, ... HC-FMUSP Pediatric Post-COVID-19 Study Group
Clinics. 2022;77C:100024
Acceso a texto completo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos