covid
Buscar en
GE - Portuguese Journal of Gastroenterology
Toda la web
Inicio GE - Portuguese Journal of Gastroenterology Upper Gastrointestinal Hemorrhage as an Unexpected Feature of Hepatocellular Car...
Información de la revista
Vol. 22. Núm. 4.
Páginas 172-174 (julio - agosto 2015)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Visitas
3829
Vol. 22. Núm. 4.
Páginas 172-174 (julio - agosto 2015)
Images in Gastroenterology and Hepatology
Open Access
Upper Gastrointestinal Hemorrhage as an Unexpected Feature of Hepatocellular Carcinoma
Um Achado Inesperado em Doente com Carcinoma Hepatocelular com Hemorragia Digestiva Alta
Visitas
3829
Rosa Coelhoa,
Autor para correspondencia
rosacoelhoabrantes@hotmail.com

Corresponding author.
, Branca Orfãoa, João Santos-Antunesa, Eduardo Rodrigues-Pintoa, Pedro Pereiraa, Helena Baldaiab, Guilherme Macedoa
a Gastroenterology Department, Centro Hospitalar de São João, Porto, Portugal
b Pathology Department, Centro Hospitalar de São João, Porto, Portugal
Este artículo ha recibido

Under a Creative Commons license
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (3)
Mostrar másMostrar menos
Texto completo
1Case report

The authors describe a 63 year old male patient with a previous diagnosis of hereditary hemochromatosis (HH) performed an abdominal computed tomography (CT) that confirmed 2 liver masses compatible with hepatocellular carcinoma (HCC). He was proposed to chemoembolization treatment however he refused it. He presented in Emergency Department, nine months after, with melenic stool and epigastric pain, the laboratory work-up revealed hemoglobin 6.5g/dL with MCV of 72.3fl. Esophagogastroduodenoscopy was performed and revealed in the anterior and superior bulb wall, protruding into the duodenal lumen, a dark reddish polypoid lesion with 30mm of maximum diameter that occluded half of the lumen (Fig. 1).

Figure 1.

Endoscopy of the upper gastrointestinal tract showing a dark reddish polypoid lesion with 30mm of maximum diameter that occluded half of the lumen of the duodenum.

(0.13MB).

Biopsies were taken as it was not actively bleeding at the time of endoscopy. Histological analysis showed a fibrin clot with hepatic phenotype cells in the peripheral area. These cells showed cytological atypia and were disaggregated (Fig. 2A). Immunohistochemical studies revealed positive tumor cells staining for Heppar-1 (Fig. 2B), HSP-70 (Fig. 2C) and glutamine synthetize (Fig. 2D). Immunostaining showed negative results for CDX-2 and glipican-3, confirming the diagnosis of locally advanced HCC. Abdominopelvic CT was performed and showed multiple liver masses located in the left hepatic lobe, with the confluent lesions measuring 19.9cm of maximum diameter, some of them occupied the right lobe (Fig. 3A). It was also possible to recognize evidence of local invasion of the first part of the duodenum (Fig. 3B). Supportive treatment was given and the patient died of hepatic coma three weeks after the episode of gastrointestinal bleeding.

Figure 2.

Histological analysis of the duodenal lesion revealed a fibrin clot with hepatic phenotype cells with cytological atypia, H&E 200× (A). Immunohistochemical studies revealed positive tumor cells staining for Heppar-1, 200× (B), HSP-70, 200× (C) and glutamine synthetize, 200× (D).

(0.28MB).
Figure 3.

Abdominal computed tomography, coronal view, showing multiple liver masses located in the left hepatic lobe with 19.9cm of maximum extension (Fig. 3A). The local invasion of the first part of the duodenum by the HCC is point out with an arrow in Fig. 3B (axial view).

(0.13MB).
2Discussion

The authors describe a case of a duodenal invasion due to an HCC with upper digestive hemorrhage. In fact, the upper gastrointestinal bleeding is one of the most common complications in patients with HCC. Common etiologies include peptic ulcer disease, variceal bleeding due to portal hypertension from underlying cirrhosis, tumor invasion of portal vein causing thrombosis and portal hypertensive gastropathy.1–4 The direct invasion of tumor to gut is considered a rare cause among patients with a non-variceal source of upper digestive hemorrhage with an estimated incidence of 0.05–2%.5–7 The authors describe a 63 year-old male patient with a diagnosis of HCC who presented with melenic stool and epigastric pain. Esophagogastroduodenoscopy revealed in the anterior and superior bulb wall, a dark reddish polypoid lesion with 30mm that occluded half of the lumen. Histological analysis confirmed the diagnosis of HCC with locally advanced disease.

Metastatic spread of HCC can be hematogenous, lymphatic or by direct invasion of the tumor into adjacent organs.4 In our case the abdominopelvic CT performed showed local invasion of the first part of the duodenum (Fig. 3B and C) making the direct tumor invasion of the gastrointestinal tract the most likely process. In conclusion, despite being a rare situation, gastrointestinal bleeding in advanced HCC should raise suspicions of duodenal involvement.

Ethical disclosuresProtection of human and animal subjects

The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data

The authors declare that no patient data appear in this article.

Right to privacy and informed consent

The authors declare that no patient data appear in this article.

Conflicts of interest

The authors have no conflicts of interest to declare.

References
[1]
C.P. Lin, J.S. Cheng, K.H. Lai, G.H. Lo, P.I. Hsu, H.H. Chan, et al.
Gastrointestinal metastasis in hepatocellular carcinoma: radiological and endoscopic studies of 11 cases.
J Gastroenterol Hepatol, 15 (2000), pp. 536-541
[2]
P. Humbert, J. Sarmiento, J. Boix, R. Planas, E. Quintero, T. Franquet, et al.
Hepatocellular carcinoma presenting with bleeding due to duodenal perforation by the tumor.
Endoscopy, 19 (1987), pp. 37-38
[3]
J.D. Liang, C.H. Chen, S.J. Hsu, J.C. Sheu, P.M. Yang, H.S. Lee, et al.
Hepatocellular carcinoma with duodenal invasion and metastasis.
J Gastroenterol Hepatol, 27 (2012), pp. 677-683
[4]
H. Sayana, O. Yousef, W.K. Clarkston.
Massive upper gastrointestinal hemorrhage due to invasive hepatocellular carcinoma and hepato-gastric fistula.
World J Gastroenterol, 19 (2013), pp. 7472-7475
[5]
W. Yeo, J.Y. Sung, S.C. Ward, S.C. Chung, W.Y. Lee, A.K. Li, et al.
A prospective study of upper gastrointestinal hemorrhage in patients with hepatocellular carcinoma.
Dis Sci, 40 (1995), pp. 2516-2521
[6]
A. Maruyama, K. Murabayashi, M. Hayashi, H. Nakano, S. Isaji, S. Uehara, et al.
Hepatocellular carcinoma complicated by gastrointestinal hemorrhage caused by direct tumor invasion of stomach.
J Hepatobiliary Pancreat Surg, 6 (1999), pp. 90-93
[7]
P. Lynch, L. Green, P.H. Jordan, D.Y. Graham.
Hepatocellular carcinoma metastatic to the stomach presenting as bleeding multiple craterogenic ulcers.
Am J Gastroenterol, 84 (1989), pp. 653-655
Copyright © 2015. Sociedade Portuguesa de Gastrenterologia
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos