10754
“Scientific Evidence for Homeopathy”Marcus Zulian Teixeira
Clinics. 2023;78C:100255
10754
Highlights
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Homeopathy is based on heterodox and complementary four scientific assumptions.
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Pseudosceptics deny these assumptions and any scientific evidence that proves them.
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The dossier describes hundreds of clinical and experimental studies in homeopathy.
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The dossier demystifies the fallacy that “there isn't scientific evidence for homeopathy”.
3075
Endoscopic Biliary Darinage (EBD) versus Percutaneous Transhepatic Biliary Drainage (PTBD) for biliary drainage in patients with Perihilar Cholangiocarcinoma (PCCA): A systematic review and meta-analysisCaroline Flaksbaum Moll, Diogo Turiani Hourneaux de Moura, Igor Braga Ribeiro, Igor Mendoça Proença, Epifanio Silvino do Monte Junior, Sergio A. Sánchez-Luna, Maria Fernanda Shinin Merchán, Josselyn Mariana Vera Intriago, ... Eduardo Guimarães Hourneaux de Moura
Clinics. 2023;78C:100163
3075
Highlights
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There is no consensus about which method is preferred for biliary drainage for Perihilar Cholangiocarcinoma (PCCA).
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Endoscopic retrograde cholangiopancreatography (EBD) or Percutaneous Transhepatic Biliary Drainage (PTBD) are options of choice.
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PTBD is superior to EBD regarding crossover rate, overall post-drainage complications, and post-drainage pancreatitis.
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EBD is superior to PTBD when it comes to hospital length of stay.
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For the palliation of PCCA, PTBD is superior to EBD in terms of clinical success and post-drainage cholangitis.
2526
Comparison of gefitinib plus chemotherapy versus gefitinib alone for advanced non‑small‑cell lung cancer: A meta analysisMin Yi, Ting He, Kaijin Wang, Yonggang Wei
Clinics. 2023;78C:100152
2526
Highlights
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This meta-analysis shows that gefitinib plus chemotherapy showed significantly better efficacy in improving objective response rate, disease control rate, progression-free survival, and OS as compared with gefitinib alone.
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Similar efficacy of gefitinib plus chemotherapy is found in the sub-population with positive EGFR mutation.
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The toxicity of gefitinib plus chemotherapy is also increased but within clinical management.
2207
Does bisphenol A (BPA) participates in the pathogenesis of Polycystic Ovary Syndrome (PCOS)?Lorena Ana Mercedes Lara Urbanetz, José Maria Soares Junior, Gustavo Arantes Rosa Maciel, Ricardo dos Santos Simões, Maria Cândida Pinheiro Baracat, Edmund Chada Baracat
Clinics. 2023;78C:100310
2207
Highlights
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Bisphenola A (BPA) is an endocrine disruptor widely investigated as a possible environmental contributor to the pathogenesis of Polycystic Ovary Syndrome (PCOS).
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Due to its structural similarity with the Estrogen molecule (E2), it acts as a xenoestrogen, binding to genomic and non-genomic estrogen receptors, causing metabolic and hormonal changes that lead to PCOS (hyperandrogenism, insulin resistance, hyperinsulinemia, obesity, atherogenic dyslipidemia, anovulation, and ovarian cysts).
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The aim and of this review were to present the mechanisms of bisphenol A participation in the pathogenesis of Polycystic Ovary Syndrome.
2142
A new systematization of histological analysis for the diagnosis of Hirschsprung's diseaseSuellen Serafini, Maria Mercês Santos, Ana Cristina Aoun Tannuri, Celso Di Loreto, Josiane de Oliveira Gonçalves, Uenis Tannuri
Clinics. 2023;78C:100198
2142
Highlights
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Hirschsprung's disease is a congenital disorder characterized by intestinal sub-occlusion and the absence of neurons in the enteric nervous system, with involvement of varying segments of the large intestine.
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The treatment is only surgical, for this reason the diagnosis must have a good accuracy.
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This research demonstrates a simplified method to perform the diagnosis with 93% of accuracy.
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The use of this method brings benefits to the patient, the pathologist, and the service.