metricas
covid
Buscar en
Gastroenterología y Hepatología (English Edition)
Toda la web
Inicio Gastroenterología y Hepatología (English Edition) Gastric Kaposi’s sarcoma as a cause of upper gastrointestinal bleeding
Información de la revista
Vol. 45. Núm. 4.
Páginas 289-290 (abril 2022)
Vol. 45. Núm. 4.
Páginas 289-290 (abril 2022)
Image of the month
Acceso a texto completo
Gastric Kaposi’s sarcoma as a cause of upper gastrointestinal bleeding
Afectación gástrica de sarcoma de Kaposi como causa de hemorragia digestiva alta
Visitas
198
Isabel Maestro Prada
Autor para correspondencia
isabelmaestroprada@gmail.com

Corresponding author.
, David Collado Pacheco
Hospital Universitario Severo Ochoa, Leganés, Madrid, Spain
Este artículo ha recibido
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (3)
Mostrar másMostrar menos
Texto completo

Kaposi sarcoma is a lymphatic endothelial cell neoplasm associated with human herpesvirus 8 (HHV-8) that is more common in males.1 Four subtypes are distinguished: classic, generally with skin involvement and sometimes with visceral involvement, which tends not to be very aggressive; endemic or African, which follows a variable course and sometimes presents with infiltrative skin lesions and visceral involvement; epidemic, which is associated with human immunodeficiency virus (HIV), with mucocutaneous and visceral involvement; and immunosuppression-associated, which is usually aggressive, with lymphatic, mucosal and visceral involvement.1–3 Kaposi sarcoma with gastrointestinal involvement is not unusual in patients with HIV, and is generally asymptomatic.4

We report the case of a 73-year-old man of Spanish origin with a history of atrial fibrillation and dilated cardiomyopathy on treatment with simvastatin and acenocoumarol. He was diagnosed with Kaposi sarcoma with exclusively cutaneous involvement, and the corresponding lesions were removed. He had not travelled outside Europe. His HIV serologies were negative, and his viral load was undetectable.

He visited the emergency department with abdominal pain and melaena, haemodynamic stability and mild anaemia, with an international normalised ratio (INR) of 1.8. Upper gastrointestinal endoscopy revealed multiple raised violaceous nodules in the gastric fundus and, in particular, the proximal gastric body, in larger numbers towards the greater curvature, with the antrum spared (Figs. 1 and 2).

Figure 1.

Endoscopic imaging showing raised violaceous nodules in the gastric body.

(0.11MB).
Figure 2.

Endoscopic imaging showing raised violaceous nodules in the gastric body.

(0.1MB).

Pathology confirmed gastric mucosa with infiltration by Kaposi sarcoma; immunohistochemistry detected HHV-8.

A review of the literature on gastrointestinal involvement in Kaposi sarcoma found that, although gastric involvement is not unusual, presentation in the form of gastrointestinal bleeding is very uncommon (Fig. 3).

Figure 3.

HHV-8 detected by immunohistochemistry, with positivity for fusiform tumour cell nuclei appearing in brown.

(0.31MB).

At the same time, the patient was diagnosed with a spermatic cord sarcoma with liver and lung metastases; despite chemotherapy, he died months later.

Funding

No funding was received for this study.

Conflicts of interest

The authors declare that they have no conflicts of interest.

References
[1]
C. Lebbe, C. Garbe, A.J. Stratigos, C. Harwood, K. Peris, V. Del Marmol, et al.
Diagnosis and treatment of Kaposi’s sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC).
Eur J Cancer, 114 (2019), pp. 117-127
[2]
S.A. Etemad, A.K. Dewan.
Kaposi sarcoma updates.
Dermatol Clin, 37 (2019), pp. 505-517
[3]
R. Vangipuram, S.K. Tyring.
Epidemiology of Kaposi sarcoma: review and description of the nonepidemic variant.
Int J Dermatol, 58 (2019), pp. 538-542
[4]
O. Akanbi, N. Saleem, S. Maddika, R. Saba.
Kaposi sarcoma: an unusual cause of gastrointestinal bleeding.

Please cite this article as: Maestro Prada I, Collado Pacheco D. Afectación gástrica de sarcoma de Kaposi como causa de hemorragia digestiva alta. Gastroenterol Hepatol. 2022;45:289–290.

Copyright © 2021. Elsevier España, S.L.U.. All rights reserved
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos