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Associations between FA supplementation in pregnancy and effects on offspring's NTDs, allergy/respiratory problems, cancer and behaviour problems as been studied.

There is growing concern about the effects of excessive FA supplementation, whether in terms of doses or times of exposure.

FA supplementation in the periconceptional period is protective against NTDs while in later periods it could be deleterious.

A daily dose of 0.4mg FA in the periconceptional period seems to be effective and safe.

Rituximab use in MG patients lead to the reduction of relapses and to a lesser use of immunosuppressive agents in our series.

Rituximab use in our MG patients decreased healthcare costs after treatment, comparing to the pre-treatment period.

Rituximab is a clinical effective treatment for B cell-related diseases like MG and seems to be a cost–saving intervention.

Chronic anal fissure is a common condition associated with intense pain.

Local botulinum toxin injection is a valid option in its management.

Pain intensity scores significantly improved after BoNT injection.

Side effects were rare and mild.

Our results support the inclusion of BoNT in the management algorithm of chronic anal fissure.

Breaking bad news is still deemed a difficult task by family physicians.

Family physicians feel they need training in breaking bad news.

The family physicians’ attitude to this issue is different from what they would wish if they themselves had a life-threatening disease.

Quality-of-life measures improve as early as 3 months after bariatric surgery.

There is wide variability in reporting that renders direct comparisons difficult.

The available comparisons between RYGB and sleeve gastrectomy could not detect any difference.

Improvement in PRO measures might be related to weight loss.

Larger and better designed studies are required to achieve discrimination in PRO measures.

Host comorbidities impact on prognosis of severe community-acquired pneumonia.

Association of severity indexes, clinical and analytic parameters at admission and patient comorbidities with mortality.

Characterization of severe community-acquired pneumonia patients admitted to ICU.

The attitudes of family physicians regarding breaking bad news are heterogeneous.

Younger doctors seem to see the delivery of bad news more positively.

This trend suggests that there will be a more open communication in the future.

Cosmos caudatus Ethanolic extract fractionation by n-butanol produced a phenolics-saponin rich fraction.

Cosmos caudatus butanol fraction was the most potent in all antioxidant and MTT assays.

High concentrations of all fractions increased cells migration and invasion in vitro.

Butanol fraction intermediate concentration maximally inhibited VSMC migration and invasion.

Mild concentrations of crude and butanol fractions showed the best invasion inhibition index.